an aminocoumarin antibiotic, C31H36N2O11, derived from Streptomyces niveus, which works by inhibiting DNA synthesis in bacteria
Examples of 'novobiocin' in a sentence
novobiocin
72% of strains were sensitive to novobiocin and 28% resistant to novobiocin.
Padmanabham Yalangi, Radhika Budumuru, Bala Chandrasekhar Pappala 2016, 'BACTERIOLOGICAL STUDY OF COAGULASE-POSITIVE AND COAGULASE-NEGATIVE STAPHYLOCOCCI INRELATION TO METHICILLIN SENSITIVITY TESTING', Journal of Evidence Based Medicine and Healthcarehttp://www.jebmh.com/data_pdf/2_Padmanabham-FINAL.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Resistance to colistin, novobiocin, erythromycin and tetracycline was observed in 100% of the isolates.
Martha Oliveira Cardoso, Aldemir Reginato Ribeiro, Luciana Ruschel dos Santos, FernandoPilotto, Hamilton L.S. de Moraes, Carlos Tadeu Pippi Salle, Silvio Luís da SilveiraRocha, Vladimir Pinheiro do Nascimento 2006, 'Antibiotic resistance in Salmonella Enteritidis isolated from broiler carcasses Resistênciaantimicrobiana em Salmonella Enteritidis isoladas de carcaças de frango', Brazilian Journal of Microbiologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000300030. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The small sensitivity was observed to novobiocin (10.46%).
Guilherme Drescher, Samara Paula Mattiello, Rodolfo Moraes Peixoto, Agueda CastagnaVargas, Marlon Nadal Maciel, Mateus Matiuzzi Costa 2010, 'BIOCHEMICAL CHARACTERIZATION AND ANTIBIOTICS SENSIBILITY OF BACTERIA AGENTS RESPONSIBLEFOR OVINE SUBCLINICAL MASTITIS IN WEST REGION OF THE SANTA CATARINA CARACTERIZAÇÃOBIOQUÍMICA E PERFIL DE SENSIBILIDADE AOS ANTIMICROBIANOS DE AGENTES BACTERIANOS ISOLADOSDE MASTITE SUBCLÍNICA OVINA NA REGIÃO OESTE DE SANTA CATARINA', Ciência Animal Brasileirahttp://www.revistas.ufg.br/index.php/vet/article/view/5189. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Penicillin, trimethoprim-sulfamethoxazole, and novobiocin-resistant strains were identified.
Alexander Delgado Duno, Julimar Zárraga, Carmen I. Chirino-Zárraga, Lilia L. CarreroPortillo 2015, 'Epidemiological Characterization of Caseous Lymphadenitis in Goat Herds in the ParaguanáPeninsula, Venezuela', Revista de Medicina Veterinariahttp://revistas.lasalle.edu.co/index.php/mv/article/view/3706. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Chemical analyses revealed structurally diverse secondary metabolites, including four new antibacterial novobiocin analogues.
Doralyn S Dalisay, David E Williams, Xiao Ling Wang, Ryan Centko, Jessie Chen, RaymondJ Andersen 2013, 'Marine sediment-derived Streptomyces bacteria from British Columbia, Canada are apromising microbiota resource for the discovery of antimicrobial natural products.',PLoS ONEhttp://europepmc.org/articles/PMC3794959?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In contrast, the isolates commonly showed resistance to novobiocin (95.89), azithromycin (57.53), and trimethropim/sulfamethoxazole(39.73).
Vanessa Zappa, Carmen Alicia Daza Bolaños, Carolina Lechinski de Paula, João LuisRevolta Callefe, Ana Carolina Alves, Amanda Bonalume Cordeiro de Morais, Simony TrevizanGuerra, Marina Chaves Cabrini, Priscilla Anne Melville, Márcio Garcia Ribeiro 2017, 'Antimicrobial multiple resistance index, minimum inhibitory concentrations, and extended-spectrumbeta-lactamase producers of Proteus mirabilis and Proteus vulgaris strains isolatedfrom domestic animals with various clinical manifestations of infection', Semina: Ciências Agráriashttp://www.uel.br/revistas/uel/index.php/semagrarias/article/view/23923. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The isolates were identifided by standard procedures based on clumping factor production and using manitol-salt agar with novobiocin disk.
Ljiljana Petrović Jeremić 2010, 'THE FREQUENCY OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN HEALTHY NASALCARRIERS IN POMORAVLJE DISTRICT', Acta Medica Medianaehttp://publisher.medfak.ni.ac.rs/2010-html/1-broj/Ljiljana%20Petrovic%20Jeremic-THEFREQUENCY%20OF%20MRSA...pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antimicrobial synergy could be detected with levofloxacin and novobiocin, targeting the gyrase enzyme, and with spectinomycin, impeding ribosomal function.
Nadja Patenge, Roberto Pappesch, Franziska Krawack, Claudia Walda, Mobarak Abu Mraheil,Anette Jacob, Torsten Hain, Bernd Kreikemeyer 2013, 'Inhibition of Growth and Gene Expression by PNA-peptide Conjugates in Streptococcuspyogenes', Molecular Therapy: Nucleic Acidshttp://www.sciencedirect.com/science/article/pii/S2162253116301937. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The most commonly observed resistance was to novobiocin (100%), lincomycin (96.8%),penicillin (96.8%) and erythromycin (90.3%).
D. Kobori, E.C. Rigobelo, C. Macedo, J. M. Marin, F. A. Avila 2004, 'Virulence Properties of Shiga Toxin-Producing Escherichia coli Isolated fromCases of Bovine Mastitis in Brazil', Revue d'Elevage et de Médecine Vétérinaire des Pays Tropicauxhttp://revues.cirad.fr/index.php/REMVT/article/view/9899. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)