a drug derived from betel nuts and producing a range of effects, including increased salivation, body temperature,and heart rate
arecoline in American English
(əˈrikəˌlin, -lɪn, əˈrekə-, ˈærɪkə-)
noun
a toxic alkaloid obtained from the seeds of the areca, used chiefly in veterinary medicine as an agent for killing and expelling intestinal worms
Word origin
[arec(a) + -ol1 + -ine2]-ol is a suffix used in the names of chemical derivatives, representing “alcohol” (glycerol; naphthol; phenol), or sometimes “phenol” or less definitely assignable phenol derivatives (resorcinol); -ine is a suffix, of no assignable meaning, appearing in nouns of Greek, Latin, or Frenchorigin. Other words that use the affix -ine include: doctrine, famine, routine
Examples of 'arecoline' in a sentence
arecoline
Arecoline, but not arecaidine or guvacine, inhibited preadipocyte viability in a concentration- and time-dependent manner.
Zi-Han Tian, Jueng-Tsueng Weng, Li-Jane Shih, An-Ci Siao, Tsai-Yun Chan, Yi-Wei Tsuei,Yow-Chii Kuo, Tsu-Shing Wang, Yung-Hsi Kao 2018, 'Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinaseand reactive oxygen species pathways.', PLoS ONEhttp://europepmc.org/articles/PMC6047799?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Heart rate was recorded before, during and after each dose of arecoline.
Argenis TORRES, Diego F. DÁVILA, Carlos F. GOTTBERG, Jose H. DONIS, Gabriela ARATADE BELLABARBA, Paolo RAMONI-PERAZZI 2000, 'Heart rate responses to a muscarinic agonist in rats with experimentally induced acuteand subacute chagasic myocarditis Repostas na frequência cardíaca provocada por umagonista muscarínico em ratos com miocardite chagásica aguda e subaguda', Revista do Instituto de Medicina Tropical de São Paulohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652000000400007. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Interestingly, c-myc promoter activity was also induced by arecoline.
Jureeporn Chuerduangphui, Tipaya Ekalaksananan, Ponlatham Chaiyarit, Natcha Patarapadungkit,Apinya Chotiyano, Bunkerd Kongyingyoes, Supannee Promthet, Chamsai Pientong 2018, 'Effects of arecoline on proliferation of oral squamous cell carcinoma cells by dysregulatingc-Myc and miR-22, directly targeting oncostatin M', PLOS ONE10.1371/journal.pone.0192009. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The specific muscarinic agonist oxotremorine and arecoline failed to elicit contractions.
Tibor Kiss, Nóra Krajcs, Zsolt Pirger, László Hernádi 2014, 'Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractionsof muscles responsible for space positioning of the snail, Helix pomatia L. tentacle.',PLoS ONEhttp://europepmc.org/articles/PMC4193815?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Menthol showed the highest enhancement effect on the flux of arecoline.
Pao-Chu Wu, Pi-Ju Tsai, Shin-Chen Lin, Yaw-Bin Huang 2014, 'Formulation Optimization of Arecoline Patches', The Scientific World Journalhttp://dx.doi.org/10.1155/2014/945168. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Consequently, our results show no pharmacological evidence of postjunctional hypersensitivity to the muscarinic agonist arecoline.
TORRES Argenis, DÁVILA Diego F., GOTTBERG Carlos F., DONIS Jose H., ARATA DE BELLABARBAGabriela, RAMONI-PERAZZI Paolo 2000, 'Heart rate responses to a muscarinic agonist in rats with experimentally induced acuteand subacute chagasic myocarditis', Revista do Instituto de Medicina Tropical de São Paulohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652000000400007. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The effects of various electrophoretic operating parameters on the analysis of arecoline were studied.
Zi-You Cai, Yong-Chong Li, Li-Hua Li, Zuan-Guang Chen 2012, 'Analysis of arecoline in Semen Arecae decoction pieces by microchip capillary electrophoresiswith contactless conductivity detection', Journal of Pharmaceutical Analysishttp://www.sciencedirect.com/science/article/pii/S209517791200086X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cytotoxicity assays were used to measure the effects of arecoline on cell viability in a dose-dependentmanner.
Ping-Ho Chen, Ka-Wo Lee, Cheng-Chieh Hsu, Jeff Yi-Fu Chen, Yan-Hsiung Wang, Ker-KongChen, Hui-Min David Wang, Hurng-Wern Huang, Bin Huang 2014, 'Expression of a Splice Variant of CYP26B1 in Betel Quid-Related Oral Cancer', The Scientific World Journalhttp://dx.doi.org/10.1155/2014/810561. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Some α7 silent agonists are effective inhibitors of inflammation, which might account for anti-inflammatory effects of arecoline.
Roger L Papke, Nicole A Horenstein, Clare Stokes 2015, 'Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggestsa Basis for Habitual Use and Anti-Inflammatory Activity.', PLoS ONEhttp://europepmc.org/articles/PMC4619380?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)