The endo:exo selectivities obtained were good although the enantiomeric excesses were low to moderate.
Paul Glynn, Joshua Howarth 2000, '2-Substituted-1,3,2-dithioborolans as Chiral Lewis Acid Catalysts', Moleculeshttp://www.mdpi.com/1420-3049/5/8/1011/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Times to resolve enantiomeric mixtures were easily larger than 30 min, or so.
Omar H. Ismail, Simona Felletti, Chiara De Luca, Luisa Pasti, Nicola Marchetti,Valentina Costa, Francesco Gasparrini, Alberto Cavazzini, Martina Catani 2018, 'The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds inLiquid and Supercritical Fluid Chromatography', Moleculeshttp://www.mdpi.com/1420-3049/23/10/2709. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Recent applications of enantiomeric separations of pharmaceuticals, amines and amino acids were reported.
Carla Fernandes, Maria Elizabeth Tiritan, Madalena M. M. Pinto 2017, 'Chiral Separation in Preparative Scale: A Brief Overview of Membranes as Tools forEnantiomeric Separation', Symmetryhttps://www.mdpi.com/2073-8994/9/10/206. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Concerning chiral micropollutants in the environment, enantiomers are frequently ignored and enantiomeric composition often neglected.
Cláudia Ribeiro, Ana Rita Ribeiro, Alexandra S. Maia, Maria Elizabeth Tiritan 2017, 'Occurrence of Chiral Bioactive Compounds in the Aquatic Environment: A Review', Symmetryhttps://www.mdpi.com/2073-8994/9/10/215. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The enantiomeric selectivity with tryptophan methyl ester was higher than that with phenylalanine methyl ester.
Min Jae Shin, Young Jae Shin, Seung Won Hwang, Jae Sup Shin 2013, 'Recognizing Amino Acid Chirality with Surface-Imprinted Polymers Prepared in W/O Emulsions',International Journal of Polymer Sciencehttp://dx.doi.org/10.1155/2013/290187. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
No losses of enantiomeric composition were observed during these processes.
Carlos D. Magnusson, Anna V. Gudmundsdottir, Kai-Anders Hansen, Gudmundur G. Haraldsson 2015, 'Synthesis of Enantiopure Reversed Structured Ether Lipids of the 1-O-Alkyl-sn-2,3-diacylglycerolType', Marine Drugshttp://www.mdpi.com/1660-3397/13/1/173. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, stereochemical transformations are possible, offering chiral products at high enantiomeric excess.
Michel Oelschlägel, Juliane Zimmerling, Dirk Tischler, Dirk Tischler 2018, 'A Review: The Styrene Metabolizing Cascade of Side-Chain Oxygenation as BiotechnologicalBasis to Gain Various Valuable Compounds', Frontiers in Microbiologyhttp://journal.frontiersin.org/article/10.3389/fmicb.2018.00490/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Beta-lactams are important antiobiotics but synthesising functionalised derivatives in high enantiomeric purity can be challenging.
Refaat B. Hamed, J. Ruben Gomez-Castellanos, Luc Henry, Sven Warhaut, Timothy D. W.Claridge, Christopher J. Schofield 2019, 'Biocatalytic production of bicyclic β-lactams with three contiguous chiral centresusing engineered crotonases', Communications Chemistryhttp://link.springer.com/article/10.1038/s42004-018-0106-z. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The three fungi showed a high degree of enantioselectivity expressed by enantiomericexcess.
Thiago Barth, Viviane C. Hilário, Bruno A. Rocha, Niege A. J. C. Furtado, Mônica T.Pupo, Anderson R. M. de Oliveira 2015, 'ASYMMETRIC SULFOXIDATION OF ALBENDAZOLE TO RICOBENDAZOLE BY FUNGI: EFFECT OF pH',Química Novahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000700944&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Enantiomeric amino acids have specific physiological functions in complex biological systems.
Ezequiel A. Belo, Jose E. M. Pereira, Paulo T. C. Freire, Dimitri N. Argyriou, JuergenEckert, Heloisa N. Bordallo 2018, 'Hydrogen bonds in crystalline d-alanine: diffraction and spectroscopic evidence fordifferences between enantiomers', IUCrJhttp://scripts.iucr.org/cgi-bin/paper?S2052252517015573. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)