an estrogenic hormone, C18H22O2, produced by the ovarian follicles and found during pregnancy in urine and placental tissue
2. Pharmacology
a commercial form of this compound, obtained from the urine of pregnant women or synthesized from ergosterol, used in the treatment of estrogen deficiency and certain menopausal and postmenopausal conditions
Also: estrin
Word origin
[1930–35; estr(in) + -one]This word is first recorded in the period 1930–35. Other words that entered Englishat around the same time include: DNA, boondoggle, cloverleaf, logical positivism, video-one is a suffix used in the names of ketones and analogous chemical compounds. Otherwords that use the affix -one include: lactone, quinone
Examples of 'estrone' in a sentence
estrone
Metabolism of 17β-estradiol was accompanied by formation of glucuronide-conjugated estrone and glucuronide-conjugated estradiol.
Gang Chen, Ying Bai, Li Ren, Dan Zhu, Yanhua Li, Meiying Fang, Huda Al-Kateb, OlenaDoran 2015, 'Metabolism of Androstenone, 17β-Estradiol and Dihydrotestosterone in Primary CulturedPig Hepatocytes and the Role of 3β-Hydroxysteroid Dehydrogenase in This Process',PLoS ONE10.1371/journal.pone.0113194. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Estrone was found as the metabolite for β-estradiol.
Gang Chen, Sicong Li, Xinxing Dong, Ying Bai, Ailiang Chen, Shuming Yang, MeiyingFang, Galia Zamaratskaia, Olena Doran 2012, 'Investigation of Testosterone, Androstenone, and Estradiol Metabolism in HepG2 Cellsand Primary Culture Pig Hepatocytes and Their Effects on 17βHSD7 Gene Expression',PLoS ONE10.1371/journal.pone.0052255. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pair-feeding was performed to determine some oleoyl-estrone effects dependent on the caloric restriction it promotes.
Marta D. Posadas, María C. Olguín, María I. Zingale, Gilda Revelant, Verónica Labourdette,María del C. Gayol, Susana Calderari 2004, 'Oleoyl-estrone metabolic effects in relation with caloric restriction in inbred Betarats with spontaneous obesity and type 2 diabetes Efectos metabólicos de la oleoil-estronaen relación con la restricción calórica en ratas Beta endocriadas, con obesidad espontáneay diabetes tipo II', Medicina (Buenos Aires)http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802004000400008. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In oleoyl-estrone and pair-fed groups hyperglycemia decreased and insulinemia lowered significantly.
Marta D. Posadas, María C. Olguín, María I. Zingale, Gilda Revelant, Verónica Labourdette,María del C. Gayol, Susana Calderari 2004, 'Oleoyl-estrone metabolic effects in relation with caloric restriction in inbred Betarats with spontaneous obesity and type 2 diabetes Efectos metabólicos de la oleoil-estronaen relación con la restricción calórica en ratas Beta endocriadas, con obesidad espontáneay diabetes tipo II', Medicina (Buenos Aires)http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802004000400008. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fasting blood for estrone and heart disease risk factors were collected at baseline.
Antonio de Padua Mansur, Tereza Cristina B. F. Silva, Julio Yoshio Takada, SolangeDesirée Avakian, Célia Maria C. Strunz, Luiz Antonio Machado César, José Mendes Aldrighi,José Antonio F. Ramires 2012, 'Long-Term Prospective Study of the Influence of Estrone Levels on Events in PostmenopausalWomen with or at High Risk for Coronary Artery Disease', The Scientific World Journalhttp://dx.doi.org/10.1100/2012/363595. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
17beta-hydroxysteroid dehydrogenase type 1 and type 2 play important roles in the activation of estrone and inactivation of estradiol.
Chen-Yan Zhang, Jiong Chen, Da-Chuan Yin, Sheng-Xiang Lin 2012, 'The Contribution of 17beta-Hydroxysteroid Dehydrogenase Type 1 to the Estradiol-EstroneRatio in Estrogen-Sensitive Breast Cancer Cells', PLoS ONE10.1371/journal.pone.0029835. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The newly-elaborated coupling procedures might have a broad applicability in the synthesis of fluorescent-labeled estrone conjugates suitable for biological assays.
Ildikó Bacsa, Csilla Konc, Anna Boglárka Orosz, Gábor Kecskeméti, Réka Rigó, CsillaÖzvegy-Laczka, Erzsébet Mernyák 2018, 'Synthesis of Novel C-2- or C-15-Labeled BODIPY—Estrone Conjugates', Moleculeshttp://www.mdpi.com/1420-3049/23/4/821. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
For estrone, 300 mg produced an overall increase of 22%, whereas 600 mg caused a 52% increase (p < 0.05).
Kreider Richard, Mulligan Chris, Taylor Lem, Wilborn Colin, Rohle Dan, WilloughbyDarryn 2007, 'Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO(androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markersin resistance-trained, eugonadal males', Journal of the International Society of Sports Nutritionhttp://www.jissn.com/content/4/1/13. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Estradiol and estrone concentrations in the conditioned tissue culture medium were measured by radioimmunoassay or immunosorbent assay.
Takako Araki, Miroslava Varadinova, Michael Goldman, Zev Rosenwaks, Leonid Poretsky,Donna Seto-Young 2011, 'Rosiglitazone and Pioglitazone Alter Aromatase Kinetic Properties in Human GranulosaCells', PPAR Researchhttp://dx.doi.org/10.1155/2011/926438. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Estrone and estradiol are both estrogens with estrone being the less potent form and estradiol being the most potent estrogen.
Chen-Yan Zhang, Jiong Chen, Da-Chuan Yin, Sheng-Xiang Lin 2012, 'The Contribution of 17beta-Hydroxysteroid Dehydrogenase Type 1 to the Estradiol-EstroneRatio in Estrogen-Sensitive Breast Cancer Cells', PLoS ONE10.1371/journal.pone.0029835. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)