any cytotoxic drug containing alkyl groups, such as chlorambucil, that acts by damaging DNA; widely used in chemotherapy
Examples of 'alkylating agent' in a sentence
alkylating agent
S44563 was administered alone or combined with fotemustine either concomitantly or after the alkylating agent.
Fariba Némati, Catherine de Montrion, Guillaume Lang, Laurence Kraus-Berthier, GuillaumeCarita, Xavier Sastre-Garau, Aurélie Berniard, David Vallerand, Olivier Geneste, Ludmillade Plater, Alain Pierré, Brian Lockhart, Laurence Desjardins, Sophie Piperno-Neumann,Stéphane Depil, Didier Decaudin 2014, 'Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derivedxenografts.', PLoS ONEhttp://europepmc.org/articles/PMC3890263?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ifosfamide, an alkylating agent used in cancer treatments, can cause neurotoxicity.
Anusha Vakiti MD, Ravi Pilla MD, Muhamad Alhaj Moustafa MD, Jacinth J. Joseph MD,Aarthi G. Shenoy MD 2018, 'Ifosfamide-Induced Metabolic Encephalopathy in 2 Patients With Cutaneous T-Cell LymphomaSuccessfully Treated With Methylene Blue', Journal of Investigative Medicine High Impact Case Reportshttps://doi.org/10.1177/2324709618786769. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This should provide further insight into a possible toxicity profile of this alkylating agent.
Shaikh Asim, Masood Nehal 2010, 'Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man:a case report', Journal of Medical Case Reportshttp://www.jmedicalcasereports.com/content/4/1/274. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Apparent plasma sulfide concentrations were found to vary substantially with sample pretreatment and nature of the alkylating agent.
T.R. Sutton, M. Minnion, F. Barbarino, G. Koster, B.O. Fernandez, A.F. Cumpstey, P.Wischmann, M. Madhani, M.P. Frenneaux, A.D. Postle, M.M. Cortese-Krott, M. Feelisch 2018, 'A robust and versatile mass spectrometry platform for comprehensive assessment ofthe thiol redox metabolome', Redox Biologyhttp://www.sciencedirect.com/science/article/pii/S2213231717309394. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hence, evaluation of copy number alterations might add relevant prognostic and predictive information concerning response to alkylating agent-based chemotherapy.
João Ramalho-Carvalho, Malini Pires, Susana Lisboa, Inês Graça, Patrícia Rocha, JoãoDiogo Barros-Silva, Joana Savva-Bordalo, Joaquina Maurício, Mário Resende, ManuelR. Teixeira, Mrinalini Honavar, Rui Henrique, Carmen Jerónimo 2013, 'Altered Expression of MGMT in High-Grade Gliomas Results from the Combined Effectof Epigenetic and Genetic Aberrations', PLoS ONE10.1371/journal.pone.0058206. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Melphalan, a nitrogen mustard alkylating agent, was used as a control agent for comparison of cytotoxic activity.
Ding-Kun Kang, Li-Yan Zhao, Hong-Li Wang 2016, 'Cytotoxic effects of local anesthesia through lidocaine/ropivacaine on human melanomacell lines', Brazilian Journal of Anesthesiologyhttp://www.sciencedirect.com/science/article/pii/S0104001416000233. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Temozolomide, an alkylating agent, initially used in the treatment of gliomas wasexpanded to include pituitary tumors in 2006.
Luis V. Syro, Fabio Rotondo, Mauricio Camargo, Leon D. Ortiz, Carlos A. Serna, KalmanKovacs 2018, 'Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and FutureDirections', Frontiers in Endocrinologyhttps://www.frontiersin.org/article/10.3389/fendo.2018.00318/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All patients had received central nervous system irradiation and adjuvant chemotherapy with at least one alkylating agent.
Nahata L, Yu RN, Dumont IP, Manley PE, Cohen LE 2013, 'Fertility in male medulloblastoma survivors: closing the gaps in counseling', Clinical Oncology in Adolescents and Young Adultshttp://www.dovepress.com/fertility-in-male-medulloblastoma-survivors-closing-the-gaps-in-counse-a15157. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The disease responded poorly to taxane- and platinum-based chemotherapies as well as an isolated limb perfusion of an alkylating agent.
Kristian Larson, Hani M. Babiker, Andrew Kovoor, Joy Liau, Jordan Eldersveld, EmadElquza 2018, 'Oral Capecitabine Achieves Response in Metastatic Eccrine Carcinoma', Case Reports in Oncological Medicinehttp://dx.doi.org/10.1155/2018/7127048. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)