any of the branched cells in the tiny cavities of bone, that are involved in the formation of bone
osteocyte in American English
(ˈɑstiəˌsait)
noun
Biology
a cell of osseous tissue within the bone matrix; a bone cell
Word origin
[1940–45; osteo- + -cyte]This word is first recorded in the period 1940–45. Other words that entered Englishat around the same time include: Rh factor, black box, redline, set-aside, zaposteo- is a combining form meaning “bone,” used in the formation of compound words. Otherwords that use the affix osteo- include: osteochondrosis, osteocope, osteomyelitis, osteoplasty, osteoporosis; -cyte is a combining form meaning “cell,” used as the final element in compound words.Other words that use the affix -cyte include: monocyte, oocyte, solenocyte, spermatocyte, thrombocyte
Examples of 'osteocyte' in a sentence
osteocyte
These changes in osteocyte density and dendritic projections occurred without differences in lacunar size.
Danielle Tokarz, Richard Cisek, Marc N. Wein, Raphaël Turcotte, Christa Haase, Shu-ChiA. Yeh, Srinidhi Bharadwaj, Anthony P. Raphael, Hari Paudel, Clemens Alt, Tzu-MingLiu, Henry M. Kronenberg, Charles P. Lin 2017, 'Intravital imaging of osteocytes in mouse calvaria using third harmonic generationmicroscopy', PLOS ONE10.1371/journal.pone.0186846. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Finally, endoxifen induced the expression of osteoblast, osteoclast and osteocyte marker genes.
Anne Gingery, Malayannan Subramaniam, Kevin S. Pitel, Jordan M. Reese, Muzaffer Cicek,Laurence B. Lindenmaier, James N. Ingle, Matthew P. Goetz, Russell T. Turner, UrszulaT. Iwaniec, Thomas C. Spelsberg, John R. Hawse 2014, 'The Effects of a Novel Hormonal Breast Cancer Therapy, Endoxifen, on the Mouse Skeleton',PLoS ONE10.1371/journal.pone.0098219. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Spherical change of osteocyte-like cells induced by mechanical stretch may be associated with autophagy upregulation.
Nao Inaba, Shinichiro Kuroshima, Yusuke Uto, Muneteru Sasaki, Takashi Sawase 2017, 'Cyclic mechanical stretch contributes to network development of osteocyte-like cellswith morphological change and autophagy promotion but without preferential cell alignmentin rat', Biochemistry and Biophysics Reportshttp://www.sciencedirect.com/science/article/pii/S2405580817300249. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition to apoptosis, other mechanisms may be involved in osteocyte loss.
Hongwang Cui, Yongjun Zhu, Dianming Jiang 2016, 'The RIP1-RIP3 Complex Mediates Osteocyte Necroptosis after Ovariectomy in Rats.',PLoS ONEhttp://europepmc.org/articles/PMC4795547?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we demonstrate an optical approach to study real-time osteocyte functions in vivo.
Hengfeng Yuan, Wen Jiang, Yuanxin Chen, Betty Y. S. Kim 2018, 'Study of Osteocyte Behavior by High-Resolution Intravital Imaging Following Photo-InducedIschemia', Moleculeshttps://www.mdpi.com/1420-3049/23/11/2874. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This study establishes the link between osteocyte thermal damage and the remodeling cascade.
Eimear B Dolan, Matthew G Haugh, Muriel C Voisin, David Tallon, Laoise M McNamara 2015, 'Thermally induced osteocyte damage initiates a remodelling signaling cascade.', PLoS ONEhttp://europepmc.org/articles/PMC4364670?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Growth hormone induces an osteoanabolic pattern and normalizes osteocyte activity.
Anke Doyon, Dagmar-Christiane Fischer, Aysun Karabay Bayazit, Nur Canpolat, Ali Duzova,Betül Sözeri, Justine Bacchetta, Ayse Balat, Anja Büscher, Cengiz Candan, Nilgun Cakar,Osman Donmez, Jiri Dusek, Martina Heckel, Günter Klaus, Sevgi Mir, Gül Özcelik, LaleSever, Rukshana Shroff, Enrico Vidal, Elke Wühl, Matthias Gondan, Anette Melk, UweQuerfeld, Dieter Haffner, Franz Schaefer 2015, 'Markers of bone metabolism are affected by renal function and growth hormone therapyin children with chronic kidney disease.', PLoS ONEhttp://europepmc.org/articles/PMC4319910?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We conclude that muscle cells naturally secrete factor(s) that preserve osteocyte viability.
K Jähn, N Lara-Castillo, L Brotto, CL Mo, ML Johnson, M Brotto, LF Bonewald 2012, 'Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosisthrough activation of β-catenin', European Cells & Materialshttp://www.ecmjournal.org/journal/papers/vol024/pdf/v024a14.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Expression of osteocyte markers was not significantly changed in the presence of osteoblasts.
Jasmin Skottke, Michael Gelinsky, Anne Bernhardt 2019, 'In Vitro Co-Culture Model of Primary Human Osteoblasts and Osteocytes in CollagenGels', International Journal of Molecular Scienceshttps://www.mdpi.com/1422-0067/20/8/1998. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We will place particular emphasis on the role of the osteocyte cytoskeleton in mechanosensing.
J Klein-Nulend, RG Bacabac, AD Bakker 2012, 'Mechanical loading and how it affects bone cells: The role of the osteocyte cytoskeletonin maintaining our skeleton', European Cells & Materialshttp://www.ecmjournal.org/journal/papers/vol024/pdf/v024a20.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)