Age-related hearing loss was the most common cause of hearing loss followed by ototoxicity.
Iliyasu Yunusa Shuaibu, Dotiro Chitumu, Ibrahim Babatunde Mohammed, Nurudeen AdebolaShofoluwe, Mohammed Aminu Usman, Aminu Bakari, Lateef Kunle Lawal 2018, 'Pattern of hearing loss in a tertiary hospital in the North Western Nigeria', Sahel Medical Journalhttp://www.smjonline.org/article.asp?issn=1118-8561;year=2018;volume=21;issue=4;spage=208;epage=212;aulast=Shuaibu. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The incidence of ototoxicity was 53.8% (n = 14).
Pao Pao Ch'ng, Siti Fatimah, Mei Mei Koid, Muna binti Martadza 2017, 'The incidence of ototoxicity in children receiving cisplatin in Hospital Pulau Pinang',Advances in Modern Oncology Researchhttp://advmodoncolres.com/index.php/AMOR/article/view/277. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The mechanism by which cisplatin causes ototoxicity remains unclear.
Mi-Jin Choi, Hyunsook Kang, Yun Yeong Lee, Oak-Sung Choo, Jeong Hun Jang, Sung-HeePark, Jong-Seok Moon, Seong Jun Choi, Yun-Hoon Choung 2019, 'Cisplatin-Induced Ototoxicity in Rats Is Driven by RIP3-Dependent Necroptosis', Cellshttps://www.mdpi.com/2073-4409/8/5/409. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Intravenous antibiotics are commonly associated with various systemic adverse effects, including renal failure and ototoxicity.
Nina Mann, Shirley Murray, Zhe Hui Hoo, Rachael Curley, Martin J. Wildman 2018, 'Case Report: Dual nebulised antibiotics among adults with cystic fibrosis and chronicPseudomonas infection [version 2; referees: 1 approved, 2 approved with reservations]',F1000Researchhttps://f1000research.com/articles/6-2079/v2. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
There was no case of nephrotoxicity or ototoxicity among our patients.
Clélia Maria Erwenne, Célia Beatriz Gianotti Antonelli, uardo Ferrari Marback, PauloEduardo Novaes 2003, 'Tratamento conservador em retinoblastoma intra-ocular Conservative treatment for intraocularretinoblastoma', Arquivos Brasileiros de Oftalmologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492003000700011. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ototoxicity was determined by patient-reported complaints as well as tone audiometrical assessments.
Chantal M. Driessen, Janneke C. Ham, Maroeska te Loo, Esther van Meerten, Mauritsvan Lamoen, Marina H. Hakobjan, Robert P. Takes, Winette T. van der Graaf, JohannesH. Kaanders, Marieke J.H. Coenen, Carla M. van Herpen 2019, 'Genetic Variants as Predictive Markers for Ototoxicity and Nephrotoxicity in Patientswith Locally Advanced Head and Neck Cancer Treated with Cisplatin-Containing Chemoradiotherapy(The PRONE Study)', Cancershttps://www.mdpi.com/2072-6694/11/4/551. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ototoxicity developed in 32%, and nephrotoxicity in 15%.
Danielle B Cohen, Geriant Davies, Wakisa Malwafu, Helen Mangochi, Elizabeth Joekes,Simon Greenwood, Liz Corbett, S Bertel Squire 2019, 'Poor outcomes in recurrent tuberculosis: More than just drug resistance?', PLoS ONEhttp://europepmc.org/articles/PMC6502344?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, severe side-effects such as ototoxicity, nephrotoxicity and neurotoxicity restrict its use.
Fazile Nur Ekinci Akdemir, Mustafa Sitki Gozeler, Serkan Yildirim, Ahmet Kiziltunc,Gizem Eser, Seda Askin 2018, 'The protective effect of coumaric acid against cisplatin-induced ototoxicity in rats',Medicine Sciencehttp://www.ejmanager.com/fulltextpdf.php?mno=285023. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Higher values are toxic, causing mainly nephrotoxicity and ototoxicity.
Marta Maria Duarte Carvalho Vila, Robson Machado de Oliveira, Marcos Moisés Gonçalves,Matthieu Tubino 2007, 'Analytical methods for vancomycin determination in biological fluids and in pharmaceuticals',Química Novahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000200029. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)