outside the pyramidal tract of the cerebral cortex and spinal cord
older antipsychotic drugs (such as chlorpromazine and haloperidol) were associatedwith a higher incidence of extrapyramidal side effects
extrapyramidal in American English
(ˌekstrəpɪˈræmɪdl)
adjective
1.
pertaining to or involving nerve tracts other than the pyramidal tracts, esp. the corpus striatum and its associated structures
2.
located outside the pyramidal tracts
Word origin
[extra- + pyramidal]extra- is a prefix meaning “outside,” “beyond,” freely used as an English formative. Otherwords that use the affix extra- include: extra-atmospheric, extrajudicial, extraterritorial
Examples of 'extrapyramidal' in a sentence
extrapyramidal
The lower co-activation levels found in the extrapyramidal group require confirmation and further investigation.
Wiles Charles M, Busse Monica E, van Deursen Robert WM 2006, 'Co-activation: its association with weakness and specific neurological pathology',Journal of NeuroEngineering and Rehabilitationhttp://www.jneuroengrehab.com/content/3/1/26. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
No significant difference existed in extrapyramidal reactions among these groups.
Xu L, Lu Y, Yang Y, Zheng Y, Chen F, Lin Z 2015, 'Olanzapine–valproate combination versus olanzapine or valproate monotherapyin the treatment of bipolar I mania: a randomized controlled study in a Chinese populationgroup', Neuropsychiatric Disease and Treatmenthttp://www.dovepress.com/olanzapinendashvalproate-combination-versus-olanzapine-or-valproate-mo-peer-reviewed-article-NDT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Patients present with pyramidal, extrapyramidal, cerebellar, psychiatric and cognitive manifestations.
Tezcan Caliskan, sabri grubuz 2013, 'Fahr's Disease', Çağdaş Tıp Dergisihttp://www.scopemed.org/fulltextpdf.php?mno=30253. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Severity of extrapyramidal symptoms was low in both groups, with no between-group differences.
P N Suresh Kumar, P K Anish, V Rajmohan 2016, 'Olanzapine has better efficacy compared to risperidone for treatment of negative symptomsin schizophrenia', Indian Journal of Psychiatryhttp://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2016;volume=58;issue=3;spage=311;epage=316;aulast=Suresh. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Extrapyramidal symptoms was significantly higher than the quetiapine group (p=0.013).
Saeed Reza Ghanbarizadeh, Hossein Dinpanah, Reza Ghasemi, Yaser Salahshour, SamanehSardashti, Mostafa Kamali, Seyed Reza Khatibi 2017, 'Quetiapine versus Haloperidol in Controlling Conversion Disorder Symptoms; a RandomizedClinical Trial', Emergencyhttp://journals.sbmu.ac.ir/emergency/article/view/22344. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Its tolerability profile, including extrapyramidal symptoms and clinically relevant metabolic parameters, was similar to placebo.
Wang SM, Han C, Lee SJ, Patkar AA, Mas, PS, Pae CU 2014, 'Schizophrenia relapse and the clinical usefulness of once-monthly aripiprazole depotinjection', Neuropsychiatric Disease and Treatmenthttp://www.dovepress.com/schizophrenia-relapse-and-the-clinical-usefulness-of-once-monthly-arip-peer-reviewed-article-NDT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Potential adverse events include clinically significant extrapyramidal symptoms and falls.
Robert Howard, Elizabeth Cort, Rosie Bradley, Emma Harper, Linda Kelly, Peter Bentham,Craig Ritchie, Suzanne Reeves, Waleed Fawzi, Gill Livingston, Andrew Sommerlad, SabuOomman, Ejaz Nazir, Ramin Nilforooshan, Robert Barber, Chris Fox, Ajay Macharouthu,Pranathi Ramachandra, Vivek Pattan, John Sykes, Valerie Curran, Cornelius Katona,Tom Dening, Martin Knapp, Renee Romeo, Richard Gray 2018, 'Amisulpride for very late-onset schizophrenia-like psychosis: the ATLAS three-armRCT', Health Technology Assessmenthttps://doi.org/10.3310/hta22670. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
No extrapyramidal reaction was observed in any group.
Kaberi Das Gupta, A. K. M. Mosharrof Hossain, Abdur Raquib Jaigirdar, Borhan Uddin,Tridiv Choudhury, Dipti Rani Saha 2007, 'Effects of ondansetron alone and in combination with domperidone in the preventionof chemotherapy-induced nausea and vomiting in breast cancer patients', Bangladesh Journal of Pharmacologyhttps://www.banglajol.info/index.php/BJP/article/view/495. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The most common treatment-related adverse events included blood prolactin increase (19.2%) and extrapyramidal disorder (19.2%).
Liang Y, Yu X 2017, 'Effectiveness of amisulpride in Chinese patients with predominantly negative symptomsof schizophrenia: a subanalysis of the ESCAPE study', Neuropsychiatric Disease and Treatmenthttps://www.dovepress.com/effectiveness-of-amisulpride-in-chinese-patients-with-predominantly-ne-peer-reviewed-article-NDT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)