Monocyte-derived cells called fibrocytes also activate fibroblasts, and we found that sialidases potentiate fibrocyte differentiation.
Tejas R. Karhadkar, Darrell Pilling, Nehemiah Cox, Richard H. Gomer 2017, 'Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-017-15198-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, iron chelation prevented tissue infiltration of ferroportin-expressing, fibrocyte-like cells.
Chhanda Bose, Judit K Megyesi, Sudhir V Shah, Kim M Hiatt, Kimberly A Hall, Oleg Karaduta,Sundararaman Swaminathan 2015, 'Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis.',PLoS ONEhttp://europepmc.org/articles/PMC4549214?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fibrocyte numbers were not correlated with other clinical or functional variables or radiologic severity scores.
Chun Li, Xiaoyu Li, Chun Deng, Chunbao Guo 2016, 'Circulating Fibrocytes Are Increased in Neonates with Bronchopulmonary Dysplasia.',PLoS ONEhttp://europepmc.org/articles/PMC4911073?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Animals in the treated groups showed significant enhancement in fibroblast, fibrocyte, and mast-cell distribution.
Mohammad Reza Farahpour, Saeed Hesaraki, Darab Faraji, Rasoul Zeinalpour, MohammadAghaei 2017, 'Hydroethanolic Allium sativum extract accelerates excision wound healing: evidencefor roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio', Brazilian Journal of Pharmaceutical Scienceshttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100605&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We also investigated the clinical value of fibrocyte counts by comparison with standard clinical parameters.
Chun Li, Xiaoyu Li, Chun Deng, Chunbao Guo 2016, 'Circulating Fibrocytes Are Increased in Neonates with Bronchopulmonary Dysplasia.',PLoS ONEhttp://europepmc.org/articles/PMC4911073?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the studies of regeneration of cochlear fibrocytes have been difficult because a suitable fibrocyte-specificdegeneration model did not exist.
Kunio eMizutari 2014, 'Spontaneous recovery of cochlear fibrocytes after severe degeneration caused by acuteenergy failure', Frontiers in Pharmacologyhttp://journal.frontiersin.org/Journal/10.3389/fphar.2014.00198/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Transcriptional analysis revealed that both types of fibrocyte are distinct from each other, fibroblasts and additional monocyte-derived progeny.
S John Curnow, Marianne Fairclough, Caroline Schmutz, Steve Kissane, Alastair K ODenniston, Kate Nash, Christopher D Buckley, Janet M Lord, Mike Salmon 2010, 'Distinct types of fibrocyte can differentiate from mononuclear cells in the presenceand absence of serum.', PLoS ONEhttp://europepmc.org/articles/PMC2841180?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In summary, the distinctive phenotype of fibrotic lung fibrocytes suggests that fibrocyte differentiation occurs primarily within the target organ.
Charles eReese, Rebecca eLee, Michael eBonner, Beth ePerry, Jonathan eHeywood, RichardM Silver, Elena eTourkina, Elena eTourkina, Richard P Visconti, Stanley eHoffman,Stanley eHoffman 2014, 'Fibrocytes in the Fibrotic Lung: Altered Phenotype Detected by Flow Cytometry', Frontiers in Pharmacologyhttp://journal.frontiersin.org/Journal/10.3389/fphar.2014.00141/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
While most previous studies focused on circulating fibrocytes, here we focus on the fibrocyte phenotype in fibrotic tissue.
Charles eReese, Rebecca eLee, Michael eBonner, Beth ePerry, Jonathan eHeywood, RichardM Silver, Elena eTourkina, Elena eTourkina, Richard P Visconti, Stanley eHoffman,Stanley eHoffman 2014, 'Fibrocytes in the Fibrotic Lung: Altered Phenotype Detected by Flow Cytometry', Frontiers in Pharmacologyhttp://journal.frontiersin.org/Journal/10.3389/fphar.2014.00141/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)