The system was also evaluated in a preliminary in vivo test in parkinsonian patients.
Faria Alvaro CD, Silva Lucia MG, Nunes Thiago P, Esteves Guilherme P, Barroso MárioC, Melo Pedro L 2011, 'A telemedicine instrument for remote evaluation of tremor: design and initial applicationsin fatigue and patients with Parkinson's Disease', BioMedical Engineering OnLinehttp://www.biomedical-engineering-online.com/content/10/1/14. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The magnetic resonance spectroscopy analyzes cerebral metabolism, yielding inconsistent results in parkinsonian disorders.
Luiz Felipe Rocha Vasconcellos, Sergio A. Pereira Novis, Denise Madeira Moreira, AnaLucia Z. Rosso, Ana Claudia C.B. Leite 2009, 'Neuroimaging in Parkinsonism: a study with magnetic resonance and spectroscopy astools in the differential diagnosis Neuroimagem no parkinsonismo: estudo com ressonânciamagnética e espectroscopia por ressonância como ferramentas no diagnóstico diferencial',Arquivos de Neuro-Psiquiatriahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000100002. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This approach was evaluated using a dataset with neuroimaging data from 87 parkinsonian patients.
Fermín Segovia, Juan M. Górriz, Juan M. Górriz, Javier Ramírez, Francisco J. Martínez-Murcia,Diego Salas-Gonzalez 2017, 'Preprocessing of 18F-DMFP-PET Data Based on Hidden Markov Random Fields and the GaussianDistribution', Frontiers in Aging Neurosciencehttp://journal.frontiersin.org/article/10.3389/fnagi.2017.00326/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A number of proteins are known to accumulate in parkinsonian brains including ubiquitin and α-synuclein.
Brotchie Jonathan M, Hilker Ruediger, Chapman Joab 2011, 'Pros and cons of a prion-like pathogenesis in Parkinson's disease', BMC Neurologyhttp://www.biomedcentral.com/1471-2377/11/74. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Parkinsonian rigidity has been thought to be constant through a full range of joint angle.
Takuyuki Endo, Toshimitsu Hamasaki, Ryuhei Okuno, Masaru Yokoe, Harutoshi Fujimura,Kenzo Akazawa, Saburo Sakoda 2013, 'Parkinsonian Rigidity Shows Variable Properties Depending on the Elbow Joint Angle',Parkinson's Diseasehttp://dx.doi.org/10.1155/2013/258374. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This may form the basis of pathological burst generation and transmission in parkinsonian conditions.
Jeremy R Edgerton, Jeremy R Edgerton, Dieter eJaeger 2014, 'Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mousereveals classic inhibition with little potential for rebound activation', Frontiers in Cellular Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fncel.2014.00036/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation.
Míriam R García, Barak A Pearlmutter, Peter E Wellstead, Richard H Middleton 2013, 'A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.',PLoS ONEhttp://europepmc.org/articles/PMC3774723?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In 2014, she developed worsening parkinsonian symptoms and autonomic dysfunction.
Hiroshi Komatsu, Masaaki Kato, Teiko Kinpara, Takashi Ono, Yoshihisa Kakuto 2018, 'Possible multiple system atrophy with predominant parkinsonism in a patient with chronicschizophrenia: a case report', BMC Psychiatryhttp://link.springer.com/article/10.1186/s12888-018-1714-y. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here we report two cases of parkinsonian patients who suffered acute pancreatitis.
Sanja Kovacic, Sinisa Roginic, Johann Nemrava, Ksenija Gospocic, Maida Seferovic Saric,Kresimir Luetic 2017, 'Acute pancreatitis in two patients with Parkinson's disease', Cogent Medicinehttp://dx.doi.org/10.1080/2331205X.2017.1312802. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It also showed neuroprotective effects on cerebrovascular and parkinsonian models.
Woo-Sang Jung, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Sang-Kwan Moon, Jung-MiPark, Chang-Nam Ko, Ki-Ho Cho 2016, 'The Effects of Chunghyul-Dan (A Korean Medicine Herbal Complex) on Cardiovascularand Cerebrovascular Diseases: A Narrative Review', Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2016/2601740. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)