a frameshift mutation is a genetic mutation in which a number of nucleotides not divisible by three are either inserted into or deleted from a nucleic acid sequence
If this process takes place in a DNA region that codes for a polypeptide chain, aframeshift mutation will result
frameshift in American English
(ˈfreimˌʃɪft)
noun
Genetics
the addition or deletion of one or more nucleotides in a strand of DNA, which shifts the codon triplets of the genetic code of messenger RNA and causes a misreading during translation, resulting in an aberrant protein and therefore a mutation
Word origin
[frame + shift]
Examples of 'frameshift' in a sentence
frameshift
No stop codons or frameshift mutations were found in any of the coding regions.
Zeng Wang, Xiaoping Zhou, Qingxian Lin, Wenzhen Fang, Xiaolin Chen 2013, 'Characterization, polymorphism and selection of major histocompatibility complex (MHC)DAB genes in vulnerable Chinese egret (Egretta eulophotes).', PLoS ONEhttp://europepmc.org/articles/PMC3760844?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
No nonsense or frameshift mutations were observed.
Meng-Ju Li, Yung-Li Yang, Ni-Chung Lee, Shiann-Tarng Jou, Meng-Yao Lu, Hsiu-Hao Chang,Kai-Hsin Lin, Ching-Tien Peng, Dong-Tsamn Lin 2016, 'Tet oncogene family member 2 gene alterations in childhood acute myeloid leukemia',Journal of the Formosan Medical Associationhttp://www.sciencedirect.com/science/article/pii/S0929664615002995. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Those tumors express multiple frameshift-mutated proteins which present a unique pool of tumor-specific antigens.
Yvette Garbe, Claudia Maletzki, Michael Linnebacher 2011, 'An MSI tumor specific frameshift mutation in a coding microsatellite of MSH3 encodesfor HLA-A0201-restricted CD8+ cytotoxic T cell epitopes.', PLoS ONEhttp://europepmc.org/articles/PMC3215711?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here we provide a novel procedure for the detection of frameshift-reverting mutations in yeast.
Erich Heidenreich, Ferdinand Steinboeck 2016, 'The sequence spectrum of frameshift reversions obtained with a novel adaptive mutationassay in Saccharomyces cerevisiae', Data in Briefhttp://www.sciencedirect.com/science/article/pii/S2352340916307211. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Approximately 80% of mutations are nonsense and frameshift mutations (small insertions or deletions).
Farmaditya E. P. Mundhofir, Helger G. Yntema, Ineke van der Burgt, Ben C. J. Hamel,Sultana M. H. Faradz, Bregje W. M. van Bon 2012, 'Mowat-Wilson Syndrome: The First Clinical and Molecular Report of an Indonesian Patient',Case Reports in Geneticshttp://dx.doi.org/10.1155/2012/949507. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This mutation causes a frameshift mutation and a premature termination at codon 358.
Zi-Ye Zhao, Yu-Liang Jiang, Bai-Rong Li, Fu Yang, Jing Li, Xiao-Wei Jin, Shou-BinNing, Shu-Han Sun 2017, 'Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germlinemutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancerrisk: case report of a Chinese patient', BMC Medical Geneticshttp://link.springer.com/article/10.1186/s12881-017-0471-y. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The mutation spectrum from our cohort comprises frameshift and splice site mutations.
Mohand-Saïd Saddek, Bujakowska Kinga, Audo Isabelle, Lancelot Marie-Elise, Moskova-DoumanovaVeselina, Waseem Naushin H, Antonio Aline, Sahel José-Alain, Bhattacharya Shomi S,Zeitz Christina 2010, 'Prevalence and novelty of PRPF31 mutations in French autosomal dominant rod-conedystrophy patients and a review of published reports', BMC Medical Geneticshttp://www.biomedcentral.com/1471-2350/11/145. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Contrary to expectations, ribosomes were not found to pause at the ribosomal frameshift site.
Nerea Irigoyen, Andrew E Firth, Joshua D Jones, Betty Y-W Chung, Stuart G Siddell,Ian Brierley 2016, 'High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and RibosomeProfiling.', PLoS Pathogenshttp://europepmc.org/articles/PMC4769073?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Mutation-resistant plasmids were constructed by interrupting the coding microsatellite sequences, preventing frameshift mutation.
Heekyung Chung, Dennis J Young, Claudia G Lopez, Thuy-Anh T Le, Jeffrey K Lee, DeenaReam-Robinson, Sherry C Huang, John M Carethers 2008, 'Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defectiveDNA mismatch repair.', PLoS ONEhttp://europepmc.org/articles/PMC2565065?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The ratio of nonsense mutation and frameshift mutation was comparatively high.
Yu Chen, Yu Lu, Pilidong Kuyaxi, Jing Cheng, Juan Zhao, Qi Zhao, Patiguli Musha, HuaZhang, Huijun Yuan 2018, 'Identification of Pathogenic Genes of Nonsyndromic Hearing Loss in Uyghur FamiliesUsing Massively Parallel DNA Sequencing Technique', Disease Markershttp://dx.doi.org/10.1155/2018/5298057. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)