a salt of fumaric acid produced during the urea cycle
fumarate in American English
(ˈfjuːməˌreit)
noun
Biochemistry
the salt of fumaric acid, a key chemical intermediate in the Krebs cycle
Word origin
[1860–65; fumar(icacid) + -ate2]This word is first recorded in the period 1860–65. Other words that entered Englishat around the same time include: Paleolithic, mutualism, pop-up, prep, trade name
Examples of 'fumarate' in a sentence
fumarate
Conversely, they exhibited lower concentrations of formate, fumarate, trehalose, α- and β-glucose.
Stanisław Deja, Piotr P. Wieczorek, Marek Halama, Izabela Jasicka-Misiak, Paweł Kafarski,Anna Poliwoda, Piotr Młynarz 2014, 'Do Differences in Chemical Composition of Stem and Cap of Amanita muscaria FruitingBodies Correlate with Topsoil Type?', PLoS ONE10.1371/journal.pone.0104084. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The methods also find applications in clinical, biological and pharmacokinetic studies of quetiapine fumarate.
Mehdi Rezaei, Ali Ramazani, Fahimeh Hokmabadi 2018, 'Quetiapine Fumarate Syntheses and Its Determination Methods in the PharmaceuticalDosage Forms, Human Plasma and Urine by RP-HPLC and Other Analytical Techniques: AReview', Chemical Methodologieshttp://www.chemmethod.com/article_60130_f83a4bac39fdd2f62d79fbbfdcaddb38.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The asymmetric unit contains two fumarate half-anions, both completed by inversion symmetry.
Ming-hua Yang 2008, 'Triaqua(N2,N4-di-2-pyridylpyrimidine-2,4-diamine)cobalt(II) fumarate', Acta Crystallographica Section Ehttp://scripts.iucr.org/cgi-bin/paper?S1600536808032613. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most of the reactivation events were properly managed by using tenofovir disoproxil fumarate.
Wen-Chi Chen, Jin-Shiung Cheng, Po-Hung Chiang, Feng-Woei Tsay, Hoi-Hung Chan, Hsueh-WenChang, Hsien-Chung Yu, Wei-Lun Tsai, Kwok-Hung Lai, Ping-I Hsu 2015, 'A Comparison of Entecavir and Lamivudine for the Prophylaxis of Hepatitis B VirusReactivation in Solid Tumor Patients Undergoing Systemic Cytotoxic Chemotherapy.',PLoS ONEhttp://europepmc.org/articles/PMC4488285?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This ennoblement has already been observed in standard media that contained fumarate.
Maha Mehanna, Régine Basséguy, Marie-Line Délia, Alain Bergel 2010, 'Geobacter sulfurreducens can protect 304L stainless steel against pitting in conditionsof low electron acceptor concentrations', Electrochemistry Communicationshttp://www.sciencedirect.com/science/article/pii/S1388248110001177. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
As expected, the mutant grows normally on fumarate under oxygen-limited conditions.
Nitanshu Garg, Aidan J. Taylor, David J. Kelly 2018, 'Bacterial periplasmic nitrate and trimethylamine-N-oxide respiration coupled to menaquinol-cytochromec reductase (Qcr): Implications for electrogenic reduction of alternative electronacceptors', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-33857-2. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Supplementary fumarate could restore the swarming motility inhibited by gentamycin.
Yijing Zhuang, Weidong Chen, Fen Yao, Yuanchun Huang, Shuqin Zhou, Haiyan Li, ZijieZhang, Congyi Cai, Yi Gao, Qing Peng 2016, 'Short-Term Pretreatment of Sub-Inhibitory Concentrations of Gentamycin Inhibits theSwarming Motility of Escherichia Coli by Down-Regulating the Succinate DehydrogenaseGene', Cellular Physiology and Biochemistryhttp://www.karger.com/Article/FullText/447835. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Participants in the oral group were given 200 mg of ferrous fumarate per day.
Shruti B. Bhavi, Purushottam B. Jaju 2017, 'Intravenous iron sucrose v/s oral ferrous fumarate for treatment of anemia in pregnancy.A randomized controlled trial', BMC Pregnancy and Childbirthhttp://link.springer.com/article/10.1186/s12884-017-1313-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here we discuss the evidence for proposing fumarate as an oncometabolite.
Ming eYang, Tomoyoshi eSoga, Patrick John Pollard, Julie eAdam 2012, 'The emerging role of fumarate as an oncometabolite', Frontiers in Oncologyhttp://journal.frontiersin.org/Journal/10.3389/fonc.2012.00085/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)