a mutation occurring in a somatic cell, resulting in a change in the morphology or some other aspect of one part of an organism (usually a plant). It may be maintained by vegetative propagation but not by sexual reproduction
Examples of 'somatic mutation' in a sentence
somatic mutation
Paternal inheritance and somatic mutation are rare.
Peterus Thajeb, Daofu Dai, Ming-Fu Chiang, Woei-Cherng Shyu 2006, 'Genotype-Phenotype Correlation of Maternally Inherited Disorders due to Mutationsin Mitochondrial DNA', Taiwanese Journal of Obstetrics & Gynecologyhttp://www.sciencedirect.com/science/article/pii/S1028455909602254. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Exome sequencing of primary tumors identifies complex somatic mutation patterns.
Thorsten Klampfl, Jelena D Milosevic, Ana Puda, Andreas Schönegger, Klaudia Bagienski,Tiina Berg, Ashot S Harutyunyan, Bettina Gisslinger, Elisa Rumi, Luca Malcovati, DanielaPietra, Chiara Elena, Matteo Giovanni Della Porta, Lisa Pieri, Paola Guglielmelli,Christoph Bock, Michael Doubek, Dana Dvorakova, Nada Suvajdzic, Dragica Tomin, NatasaTosic, Zdenek Racil, Michael Steurer, Sonja Pavlovic, Alessandro M Vannucchi, MarioCazzola, Heinz Gisslinger, Robert Kralovics 2013, 'Complex patterns of chromosome 11 aberrations in myeloid malignancies target CBL,MLL, DDB1 and LMO2.', PLoS ONEhttp://europepmc.org/articles/PMC3797696?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Somatic mutation and copy number alteration were analyzed.
Sae-Won Han, Hwang-Phill Kim, Jong-Yeon Shin, Eun-Goo Jeong, Won-Chul Lee, Kyung-HunLee, Jae-Kyung Won, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Seung-YongJeong, Kyu Joo Park, Jae-Gahb Park, Gyeong Hoon Kang, Jeong-Sun Seo, Jong-Il Kim,Tae-You Kim 2013, 'Targeted Sequencing of Cancer-Related Genes in Colorectal Cancer Using Next-GenerationSequencing', PLoS ONE10.1371/journal.pone.0064271. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
About 90% of patients harbor at least one somatic mutation.
Saeid Shahrabi, Abbas Khosravi, Mohammad Shahjahani, Fakher Rahim, Najmaldin Saki 2016, 'Genetics and epigenetics of myelodysplastic syndromes and response to drug therapy:new insights', Oncology Reviewshttp://www.oncologyreviews.org/index.php/or/article/view/311. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Slight within-basic sequence variation detected in all individuals was attributed to somatic mutation.
Manuel Vera, Paulino Martínez, Laura Poisa-Beiro, Antonio Figueras, Beatriz Novoa 2011, 'Genomic Organization, Molecular Diversification, and Evolution of Antimicrobial PeptideMyticin-C Genes in the Mussel (Mytilus galloprovincialis)', PLoS ONE10.1371/journal.pone.0024041. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most embryos showed severe mutant phenotypes carrying high somatic mutation rates.
Yuto Sakane, Midori Iida, Takashi Hasebe, Satoshi Fujii, Daniel R. Buchholz, AtsukoIshizuya-Oka, Takashi Yamamoto, Ken-ichi T. Suzuki 2018, 'Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis foundersusing CRISPR-Cas', Biology Openhttp://bio.biologists.org/content/7/1/bio030338. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This flexible approach could be widely used for somatic mutation detection in clinical settings.
Najie Song, Xueting Zhong, Qingge Li 2014, 'Real-time bidirectional pyrophosphorolysis-activated polymerization for quantitativedetection of somatic mutations.', PLoS ONEhttp://europepmc.org/articles/PMC4000192?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, we observed strong associations between methylation in specific genomic regions and somatic mutation patterns.
Jianxin Shi, Xing Hua, Bin Zhu, Sarangan Ravichandran, Mingyi Wang, Cu Nguyen, SethA Brodie, Alessandro Palleschi, Marco Alloisio, Gianluca Pariscenti, Kristine Jones,Weiyin Zhou, Aaron J Bouk, Joseph Boland, Belynda Hicks, Adam Risch, Adam Risch, HunterBennett, Brian T Luke, Lei Song, Jubao Duan, Pengyuan Liu, Takashi Kohno, QingrongChen, Daoud Meerzaman, Crystal Marconett, Ite Laird-Offringa, Ian Mills, Neil E Caporaso,Mitchell H Gail, Angela C Pesatori, Dario Consonni, Pier Alberto Bertazzi, StephenJ Chanock, Maria Teresa Landi 2016, 'Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.',PLoS Medicinehttp://europepmc.org/articles/PMC5140047?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, overall, somatic mutation profiles including potential drivers were maintained upon implantation and serial passaging.
Priscilla F McAuliffe, Kurt W Evans, Argun Akcakanat, Ken Chen, Xiaofeng Zheng, HaoZhao, Agda Karina Eterovic, Takafumi Sangai, Ashley M Holder, Chandeshwar Sharma,Huiqin Chen, Kim-Anh Do, Emily Tarco, Mihai Gagea, Katherine A Naff, Aysegul Sahin,Asha S Multani, Dalliah M Black, Elizabeth A Mittendorf, Isabelle Bedrosian, GordonB Mills, Ana Maria Gonzalez-Angulo, Funda Meric-Bernstam 2015, 'Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in ChemoresistantDisease and Predicts Poor Patient Outcomes.', PLoS ONEhttp://europepmc.org/articles/PMC4556673?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Polycythemia vera can be confirmed with high specificity and sensitivity by the acquired somatic mutation.
Lin Ming-Shyan, Hung Yu-Shin, Wu Hsueh-Hua, Kuo Ming-Chung, Shiu Tzu-Fang, ChuangCheng-Keng, Shih Lee-Yung, Chu Pao-Hsien 2009, 'Polycythemia vera as a presentation of renal angiomyolipoma: a case report', Journal of Medical Case Reportshttp://www.jmedicalcasereports.com/content/3/1/90. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)