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单词 pentose phosphate pathway
释义

pentose phosphate pathway in British English

noun
a sequence of metabolic reactions by which NADPH is synthesized, together with ribose phosphate, part of the synthesis of nucleic acids

Examples of 'pentose phosphate pathway' in a sentence
pentose phosphate pathway

Thus, gluconate must be metabolized through the pentose phosphate pathway.
ANTONIETTA PORCO, ELIDA E GAMERO, ELENA MYLONÁS, TOMÁS ISTÚRIZ 2008, 'Gluconate as suitable potential reduction supplier in Corynebacterium glutamicum:Cloning and expression of gntP and gntK in Escherichia coli', Biological Researchhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000300011. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The pentose phosphate pathway and glutathione-associated metabolism are the main antioxidant cellular defense systems.
Ulusu Nuray Nuriye, Gök Müslüm, Sayin Şakul Arzu Ayşe, Ari Nuray, Stefek Milan, KarasuÇimen 2017, 'Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependentenzyme activities in tissues of aged diabetic rats', Interdisciplinary Toxicologyhttp://www.degruyter.com/view/j/intox.2017.10.issue-4/intox-2017-0021/intox-2017-0021.xml?format=INT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Increased nucleotide concentrations were present, potentially indicating increased flux through the pentose phosphate pathway.
Nikolaos A. Diakos, MD, PhD, Sutip Navankasattusas, PhD, E. Dale Abel, MD, PhD, JaredRutter, PhD, Lauren McCreath, BS, Peter Ferrin, BS, Stephen H. McKellar, MD, DylanV. Miller, MD, Song Y. Park, PhD, Russell S. Richardson, PhD, Ralph Deberardinis,MD, James E. Cox, PhD, Abdallah G. Kfoury, MD, Craig H. Selzman, MD, Josef Stehlik,MD, James C. Fang, MD, Dean Y. Li, MD, PhD, Stavros G. Drakos, MD, PhD 2016, 'Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation MismatchDuring Mechanical Unloading of the Failing Human Heart', JACC: Basic to Translational Sciencehttp://www.sciencedirect.com/science/article/pii/S2452302X16301097. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Inhibition of the pentose phosphate pathway resulted in apoptosis preferentially in quiescent fibroblasts.
Johanna M S Lemons, Xiao-Jiang Feng, Bryson D Bennett, Aster Legesse-Miller, ElizabethL Johnson, Irene Raitman, Elizabeth A Pollina, Herschel A Rabitz, Joshua D Rabinowitz,Hilary A Coller 2010, 'Quiescent fibroblasts exhibit high metabolic activity.', PLoS Biologyhttp://europepmc.org/articles/PMC2958657?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Increased expression of these isoenzymes matches to increased fluxes in the pentose phosphate pathway.
Wouter Daniels, Jeroen Bouvin, Tobias Busche, Christian Rückert, Kenneth Simoens,Spyridoula Karamanou, Lieve Van Mellaert, Ólafur H. Friðjónsson, Bart Nicolai, AnastassiosEconomou, Jörn Kalinowski, Jozef Anné, Kristel Bernaerts 2018, 'Transcriptomic and fluxomic changes in Streptomyces lividans producing heterologousprotein', Microbial Cell Factorieshttp://link.springer.com/article/10.1186/s12934-018-1040-6. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Besides, several proteins participating in the pentose phosphate pathway and tricarboxylic acid cycle were also up-regulated.
Qian Ma, Weiwen Zhang, Lu Zhang, Bin Qiao, Chensong Pan, Hong Yi, Lili Wang, Ying-jinYuan 2012, 'Proteomic Analysis of Ketogulonicigenium vulgare under Glutathione Reveals High Demandfor Thiamin Transport and Antioxidant Protection', PLoS ONE10.1371/journal.pone.0032156. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The expression of proteins involved in energy metabolism (mitochondrial respiratory chain and pentose phosphate pathway) was found to be affected.
Tiago Ribeiro, Filipa Lemos, Marco Preto, Joana Azevedo, Maria Lígia Sousa, PedroN. Leão, Alexandre Campos, Stig Linder, Rui Vitorino, Vitor Vasconcelos, Ralph Urbatzka 2017, 'Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanismsof action', PLOS ONE10.1371/journal.pone.0188817. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Some steps that link glycolysis and pentose phosphate pathway revealed their importance for controlling the dynamics of cancer glucose metabolism.
Ettore eMosca, Roberta eAlfieri, Carlo eMaj, Annamaria eBevilacqua, Annamaria eBevilacqua,Gianfranco eCanti, Luciano eMilanesi 2012, 'Computational Modelling of the Metabolic States Regulated by the Kinase Akt', Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2012.00418/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This results in a lower flux through the pentose phosphate pathway, demonstrated by the down-regulation of the phosphoketolases.
Lars Poulsen, Mikael Rørdam Andersen, Anna Eliasson Lantz, Jette Thykaer 2012, 'Identification of a Transcription Factor Controlling pH-Dependent Organic Acid Responsein Aspergillus niger', PLoS ONE10.1371/journal.pone.0050596. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The energy carrying molecule generated by cellular respiration and by pentose phosphate pathway, an alternative pathway of glucose metabolism.
Diane E. Mahoney, John B. Hiebert, Amanda Thimmesch, John T. Pierce, James L. Vacek,Richard L. Clancy, Andrew J. Sauer, Janet D. Pierce 2018, 'Understanding D-Ribose and Mitochondrial Function', Advances in Bioscience and Clinical Medicinehttps://journals.aiac.org.au/index.php/ABCMED/article/view/4131. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
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