material added to a statement, story, etc, in order to expand or clarify it
3.
a statement, story, etc, with such additional material
4. electronics
a.
the increase in strength of an electrical signal by means of an amplifier
b. another word for gain1 (sense 13)
5. Also called: gene amplification genetics
the production of multiple copies of a particular gene or DNA sequence. It can occur naturally or artificially, by genetic engineering techniques
gene amplification in American English
noun
1.
an increase in the frequency of replication of a DNA segment
2.
such an increase induced by a polymerase chain reaction
Word origin
[1970–75]This word is first recorded in the period 1970–75. Other words that entered Englishat around the same time include: New Age, cornrow, postmodernism, stress test, urban legend
Examples of 'gene amplification' in a sentence
gene amplification
No gene amplification was found.
Magnus B Arnli, Theo L Winther, Stian Lydersen, Sverre H Torp 2018, 'Prognostic value of ErbB2/HER2 in human meningiomas.', PLoS ONEhttp://europepmc.org/articles/PMC6193666?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The mutation was associated with gene amplification.
Lea Loriguet, Mony Chenda Morisse, Julie Dremaux, Louison Collet, Christophe Attencourt,Alexandre Coutte, Mathieu Boone, Henri Sevestre, Antoine Galmiche, Brigitte Gubler,Bruno Chauffert, Stephanie Trudel 2018, 'Combining genomic analyses with tumour-derived slice cultures for the characterizationof an EGFR-activating kinase mutation in a case of glioblastoma', BMC Cancerhttp://link.springer.com/article/10.1186/s12885-018-4873-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
There was no evidence of gene amplification.
Valeria Pecce, Marialuisa Sponziello, Giuseppe Damante, Francesca Rosignolo, CosimoDurante, Livia Lamartina, Giorgio Grani, Diego Russo, Cira Rosaria di Gioia, SebastianoFiletti, Antonella Verrienti 2018, 'A synonymous RET substitution enhances the oncogenic effect of an in-cis missensemutation by increasing constitutive splicing efficiency.', PLoS Geneticshttp://europepmc.org/articles/PMC6201961?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Therefore, partial gene amplification may function in silencing gene expression.
Oscar Vazquez-Mena, Ingrid Medina-Martinez, Eligia Juárez-Torres, Valeria Barrón,Ana Espinosa, Nicolás Villegas-Sepulveda, Laura Gómez-Laguna, Karem Nieto-Martínez,Lorena Orozco, Edgar Roman-Basaure, Sergio Muñoz Cortez, Manuel Borges Ibañez, CarlosVenegas-Vega, Mariano Guardado-Estrada, Angélica Rangel-López, Susana Kofman, JaimeBerumen 2012, 'Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancercell lines.', PLoS ONEhttp://europepmc.org/articles/PMC3296745?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, pfmdr1 gene amplification was not detected.
Zenglei Wang, Daniel Parker, Hao Meng, Lanou Wu, Jia Li, Zhen Zhao, Rongping Zhang,Miao Miao, Qi Fan, Haiyan Wang, Liwang Cui, Zhaoqing Yang 2012, 'In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to majorACT drugs and polymorphisms in potential target genes.', PLoS ONEhttp://europepmc.org/articles/PMC3365119?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Double minute chromosomes are cytogenetic manifestations of gene amplification frequently seen in cancer cells.
Lisa Yu, Yan Zhao, Chao Quan, Wei Ji, Jing Zhu, Yun Huang, Rongwei Guan, Donglin Sun,Yan Jin, Xiangning Meng, Chunyu Zhang, Yang Yu, Jing Bai, Wenjing Sun, Songbin Fu 2013, 'Gemcitabine Eliminates Double Minute Chromosomes from Human Ovarian Cancer Cells',PLoS ONE10.1371/journal.pone.0071988. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The gene amplification plays a critical role in the malignant transformation of mammalian cells.
Shun-suke Tanaka, Sho-hei Mitsuda, Noriaki Shimizu 2014, 'How a Replication Origin and Matrix Attachment Region Accelerate Gene Amplificationunder Replication Stress in Mammalian Cells', PLoS ONE10.1371/journal.pone.0103439. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Interplay of fragile sites in promoting gene amplification was also elucidated.
Shelly Sehgal, Sanjana Kaul, M. K. Dhar 2015, 'Mechanism of Gene Amplification via Yeast Autonomously Replicating Sequences', The Scientific World Journalhttp://dx.doi.org/10.1155/2015/387367. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Gene amplification of specific loci has been described in all kingdoms of life.
Jean-Michel Ubeda, Frédéric Raymond, Angana Mukherjee, Marie Plourde, Hélène Gingras,Gaétan Roy, Andréanne Lapointe, Philippe Leprohon, Barbara Papadopoulou, Jacques Corbeil,Marc Ouellette 2014, 'Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeatsin the parasite Leishmania.', PLoS Biologyhttp://europepmc.org/articles/PMC4028189?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)