a colorless crystalline compound, C7H6N2, used in organic synthesis
Also called: benzoglyoxaline
Word origin
[1925–30; benz- + imidazole]This word is first recorded in the period 1925–30. Other words that entered Englishat around the same time include: chain reaction, decibel, gimmick, off-line, reflex camera
Examples of 'benzimidazole' in a sentence
benzimidazole
The benzimidazole-treated (med) group included 15 patients with 17 cysts.
Marija Stojkovic, Kerstin Daniela Rosenberger, Franziska Steudle, Thomas Junghanss 2016, 'Watch and Wait Management of Inactive Cystic Echinococcosis - Does the Path to InactivityMatter - Analysis of a Prospective Patient Cohort.', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC5207761?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this work the biological activity of some benzimidazole-4,7-diones was evaluated.
Katarzyna Błaszczak-Świątkiewicz, Elżbieta Mikiciuk-Olasik 2014, 'Biological Evaluation of the Activity of Some Benzimidazole-4,7-dione Derivatives',Moleculeshttp://www.mdpi.com/1420-3049/19/10/15361. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Some new 2- phenyl benzimidazole derivatives were synthesised by cyclocondensation with appropriate reagents.
Y. S. Chhonker, B. Veenu, S. R. Hasim, Niranjan Kaushik, Devendra Kumar, Pradeep Kumar 2009, 'Synthesis and Pharmacological Evaluation of Some New 2-Phenyl benzimidazoles Derivativesand their Schiff's Bases', E-Journal of Chemistryhttp://dx.doi.org/10.1155/2009/604203. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The paper presents the synthesis of benzimidazole derivatives starting from asparagicacid.
V. Sunel, M. Popa, L. Verestiuc, C. Ivanov, A. A. Popa 2003, 'Aminoacids Derivatives with a Potential Anti-inflammatory Activity', Eurasian Chemico-Technological Journal http://ect-journal.kz/index.php/ectj/article/view/563. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Substituents in morpholine and benzimidazole rings cause increase and decrease of ligand-protein binding, respectively.
Liudmyla K. Sviatenko, Oksana V. Tereshchenko 2014, 'Molecular docking of ZSTK474 derivatives as potential PI3K-delta inhibitory agents',Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Hìmìâhttp://chemistry.dnu.dp.ua/article/view/24563. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here we fabricated a novel high performance aramid fiber containing benzimidazole moieties and chloride substitutions.
Longbo Luo, Yihao Yuan, Yu Dai, Zheng Cheng, Xu Wang, Xiangyang Liu 2018, 'The novel high performance aramid fibers containing benzimidazole moieties and chloridesubstitutions', Materials & Designhttp://www.sciencedirect.com/science/article/pii/S0264127518306403. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Chelation results in a six-membered boat-shaped ring which links the benzimidazole groups.
Robert T. Stibrany, Joseph A. Potenza 2010, 'Dibromido[1,1′-dibutyl-2,2′-(pentane-1,1-diyl)di-1H-benzimidazole]copper(II)', Acta Crystallographica Section Ehttp://scripts.iucr.org/cgi-bin/paper?S160053681002088X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation.
Mahadev N. Kumbar, Ravindra R. Kamble, Atulkumar A. Kamble, Sujith Raj Salian, SandhyaKumari, Ramya Nair, Guruprasad Kalthur, Satish Kumar Adiga, D. Jagadeesh Prasad 2016, 'Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors',International Journal of Medicinal Chemistryhttp://dx.doi.org/10.1155/2016/9890630. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Benzimidazole agents are the vital pharmacophore and privileged sub-structures in chemistry of medicine.
Sumit Tahlan, Sanjiv Kumar, Balasubramanian Narasimhan 2019, 'Antimicrobial potential of 1H-benzo[d]imidazole scaffold: a review', BMC Chemistryhttp://link.springer.com/article/10.1186/s13065-019-0521-y. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)