a cavity or area within a cell in which matter is retained in the process of phagocytosis
The internalized phagocytic vesicle or phagosome then fuses with lysosomes
phagosome in American English
(ˈfæɡəˌsoum)
noun
a vacuole within a phagocyte that contains bacteria or other ingested particles and that becomes fused with a lysosome
Word origin
[1955–60; phago- + -some3]This word is first recorded in the period 1955–60. Other words that entered Englishat around the same time include: cassette, geodesic dome, life-support, new wave, opioid-some is a combining form meaning “body,” used in the formation of compound words. Otherwords that use the affix -some include: chromosome, endosome, mesosome, microsome, monosome
Examples of 'phagosome' in a sentence
phagosome
Mtb has various survival strategies, including blockade of phagosome maturation and inhibition of antigen presentation.
Hyo-Ji Lee, Hyo-Ji Lee, Hyun-Jeong Ko, Dong-Kun Song, Yu-Jin Jung 2018, 'Lysophosphatidylcholine Promotes Phagosome Maturation and Regulates Inflammatory MediatorProduction Through the Protein Kinase A–Phosphatidylinositol 3 Kinase–p38 Mitogen-ActivatedProtein Kinase Signaling Pathway During Mycobacterium tuberculosis Infection in MouseMacrophages', Frontiers in Immunologyhttp://journal.frontiersin.org/article/10.3389/fimmu.2018.00920/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ehrlichiae are small, gram-negative, obligately intracellular bacteria that reside within a phagosome.
David H. Walker, J. Stephen Dumler 1996, 'Emergence of the Ehrlichioses as Human Health Problems', Emerging Infectious Diseaseshttps://wwwnc.cdc.gov/eid/article/2/1/96-0102_article. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Overall, the increase in alkalinity within the phagosome was associated with increased oxidase activity.
Juliet R. Foote, Amit A. Patel, Simon Yona, Anthony W. Segal 2019, 'Variations in the Phagosomal Environment of Human Neutrophils and Mononuclear PhagocyteSubsets', Frontiers in Immunologyhttps://www.frontiersin.org/article/10.3389/fimmu.2019.00188/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The phagosome microenvironment maintains enzyme activity and function.
Juliet R. Foote, Amit A. Patel, Simon Yona, Anthony W. Segal 2019, 'Variations in the Phagosomal Environment of Human Neutrophils and Mononuclear PhagocyteSubsets', Frontiers in Immunologyhttps://www.frontiersin.org/article/10.3389/fimmu.2019.00188/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Rab39a has pleiotropic functions in phagosome maturation, inflammatory activation and neuritogenesis.
Shintaro Seto, Keiko Sugaya, Kunio Tsujimura, Toshi Nagata, Toshinobu Horii, YukioKoide 2013, 'Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagyinduced by lipopolysaccharide stimulation in macrophages.', PLoS ONEhttp://europepmc.org/articles/PMC3862771?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Confocal analyses of phagosome acidification and maturation were performed.
Natalie Fischer, Tim N. Mak, Debika Biswal Shinohara, Karen S. Sfanos, Thomas F. Meyer,Holger Brüggemann 2013, 'Deciphering the Intracellular Fate of Propionibacterium acnes in Macrophages', BioMed Research Internationalhttp://dx.doi.org/10.1155/2013/603046. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Reactive oxygen species and reactive nitrogen species are produced inside the phagosome.
Oliver Nüsse 2011, 'Biochemistry of the Phagosome: The Challenge to Study a Transient Organelle', The Scientific World Journalhttp://dx.doi.org/10.1100/2011/741046. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Its depletion allows for rapid phagosome acidification and promotes phagolysosomefusion.
Natalie E. Nieuwenhuizen, Prasad S. Kulkarni, Umesh Shaligram, Mark F. Cotton, CyrillA. Rentsch, Cyrill A. Rentsch, Bernd Eisele, Leander Grode, Stefan H. E. Kaufmann 2017, 'The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical EfficacyTesting', Frontiers in Immunologyhttp://journal.frontiersin.org/article/10.3389/fimmu.2017.01147/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Probes that are easily targeted to the phagosome by using established approaches are emphasized.
Dale R. Balce, Robin M. Yates 2013, 'Redox-sensitive probes for the measurement of redox chemistries within phagosomesof macrophages and dendritic cells', Redox Biologyhttp://www.sciencedirect.com/science/article/pii/S2213231713000669. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)