Their hepatic gluconeogenic enzyme activities were increased.
Kalle Anand Kumar, Anumula Lalitha, Umakar Reddy, Giriraj Ratan Chandak, ShantanuSengupta, Manchala Raghunath 2014, 'Chronic maternal vitamin B12 restriction induced changes in body composition & glucosemetabolism in the Wistar rat offspring are partly correctable by rehabilitation.',PLoS ONEhttp://europepmc.org/articles/PMC4232526?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Between 15 and 120 minutes, the load contribution fell whereas the gluconeogenic contribution remained constant.
Teresa C Delgado, Cristina Barosa, Patrícia M Nunes, Sebastián Cerdán, Carlos F GC Geraldes, John G Jones 2012, 'Resolving the sources of plasma glucose excursions following a glucose tolerance testin the rat with deuterated water and [U-13C]glucose.', PLoS ONEhttp://europepmc.org/articles/PMC3316706?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hepatic responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia was investigated.
H.M. de Souza, G.R. Borba-Murad, R.B. Ceddia, R. Curi, M. Vardanega-Peicher, R.B.Bazotte 2001, 'Rat liver responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia',Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hepatic gluconeogenic gene expression levels were associated with intramuscular fat deposition.
Dilla Mareistia Fassah, Jin Young Jeong, Myunggi Baik 2018, 'Hepatic transcriptional changes in critical genes for gluconeogenesis following castrationof bulls', Asian-Australasian Journal of Animal Scienceshttp://www.ajas.info/upload/pdf/ajas-31-4-537.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
To further link these interactors to glucose production, key gluconeogenic genes were assessed.
Junfeng Han, Ming Zhang, Sean Froese, Feihan F Dai, Mélanie Robitaille, Alpana Bhattacharjee,Xinyi Huang, Weiping Jia, Stéphane Angers, Michael B Wheeler, Li Wei 2015, 'The Identification of Novel Protein-Protein Interactions in Liver that Affect GlucagonReceptor Activity.', PLoS ONEhttp://europepmc.org/articles/PMC4468146?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The branching phenotype was medium dependent and probably linked to gluconeogenic growth.
André S. G. Lorenzoni, Giordanni C. Dantas, Tessa Bergsma, Henrique Ferreira, Dirk-JanScheffers 2017, 'Xanthomonas citri MinC Oscillates from Pole to Pole to Ensure Proper Cell Divisionand Shape', Frontiers in Microbiologyhttp://journal.frontiersin.org/article/10.3389/fmicb.2017.01352/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Initially, the acetate uptake and gluconeogenic pathway were amplified to maximize the flux toward tyrosine.
Minji Jo, Myung Hyun Noh, Hyun Gyu Lim, Chae Won Kang, Dae-Kyun Im, Min-Kyu Oh, GyooYeol Jung 2019, 'Precise tuning of the glyoxylate cycle in Escherichia coli for efficient tyrosineproduction from acetate', Microbial Cell Factorieshttp://link.springer.com/article/10.1186/s12934-019-1106-0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Canonical insulin signaling and gluconeogenic genes were measured by western blot and quantitative polymerase chain reaction.
Chen Juan Gu, Hua Hua Yi, Jing Feng, Zhi Guo Zhang, Jun Zhou, Li Na Zhou, Jian PingZhou, Min Li, Qing Yun Li 2018, 'Intermittent Hypoxia Disrupts Glucose Homeostasis in Liver Cells in an Insulin-Dependentand Independent Manner', Cellular Physiology and Biochemistryhttps://www.karger.com/Article/FullText/490169. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The results indicate that the hepatic capacity to produce glucose from gluconeogenicprecursors was increased during insulin-induced hypoglycemia.
H.M. de Souza, G.R. Borba-Murad, R.B. Ceddia, R. Curi, M. Vardanega-Peicher, R.B.Bazotte 2001, 'Rat liver responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia',Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Db model hepatocytes showed several disease-specific phenotypes, namely disturbance of insulin-induced repression of gluconeogenic gene expression and glucose secretion.
Fumi Kano, Yoshiyuki Noguchi, Masayuki Murata 2017, 'Establishment and phenotyping of disease model cells created by cell-resealing technique',Scientific Reportshttp://link.springer.com/article/10.1038/s41598-017-15443-0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)