an antibiotic, C14H24N2O7, made synthetically or obtained from an actinomycete (Streptomyces spectabilis) and used esp. in treating cases of gonorrhea that are resistant to penicillin
Examples of 'spectinomycin' in a sentence
spectinomycin
Azithromycin in combination with gentamicin or spectinomycin has been recommended in treatment failure cases.
Vikram Singh, Manju Bala, Aradhana Bhargava, Monika Kakran, Ravi Bhatnagar 2018, 'In vitro efficacy of 21 dual antimicrobial combinations comprising novel and currentlyrecommended combinations for treatment of drug resistant gonorrhoea in future era.',PLoS ONEhttp://europepmc.org/articles/PMC5839552?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Spectinomycin (100 mg) presented the lowest efficiency, 45.5%.
Sandra M. Borowski, Nilo Ikuta, Vagner Lunge, André Fonseca, Edmundo Marques, MarisaCardoso 2002, 'Caracterização antigênica e fenotípica de cepas de Pasteurella multocida isoladasde pulmões de suínos com pneumonia e/ou pleurite Antigenic and phenotypic characterizationof Pasteurella multocida strains isolated from the lungs of pigs with pneumonia and/orpleuritic lesions', Pesquisa Veterinária Brasileirahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2002000300002. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All the isolates were susceptible to ceftriaxone, cefixime, and spectinomycin.
Sethi Sunil, Golparian Daniel, Bala Manju, Dorji Dorji, Ibrahim Muhammad, Jabeen Kausar,Unemo Magnus 2013, 'Antimicrobial susceptibility and genetic characteristics of Neisseria gonorrhoeaeisolates from India, Pakistan and Bhutan in 2007–2011', BMC Infectious Diseaseshttp://www.biomedcentral.com/1471-2334/13/35. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The gene cassettes identified were those for trimethoprim, streptomycin, spectinomycin and streptothricin.
Chetna Dureja, Sakshi Mahajan, Saumya Raychaudhuri 2014, 'Phylogenetic distribution and prevalence of genes encoding class I Integrons and CTX-M-15extended-spectrum β-lactamases in Escherichia coli isolates from healthy humans inChandigarh, India.', PLoS ONEhttp://europepmc.org/articles/PMC4237346?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The integrons contained diverse cassette arrays that encoded resistance to streptomycin, spectinomycin, and trimethoprim.
Michelle L. Power, Samantha Emery, Michael R. Gillings 2013, 'Into the Wild: Dissemination of Antibiotic Resistance Determinants via a Species RecoveryProgram', PLoS ONE10.1371/journal.pone.0063017. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All members of this subclass can inactivate streptomycin and spectinomycin.
Gang Zhang, Sébastien Olivier Leclercq, Jingjing Tian, Chao Wang, Koji Yahara, GuominAi, Shuangjiang Liu, Jie Feng 2017, 'A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, ishorizontally transferred among Acinetobacter spp. by homologous recombination.', PLoS Geneticshttp://europepmc.org/articles/PMC5313234?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All strains were sensitive to gentamicin and lincomycin-spectinomycin and 80% of them to colistin.
Suzete Lora Kuana, Luciana Ruschel dos Santos, Laura Beatriz Rodrigues, AnderliseBorsoi, Hamilton Luis do Souza Moraes, Carlos Tadeu Pippi Salle, Vladimir Pinheirodo Nascimento 2008, 'Antimicrobial resistance in Campylobacter spp isolated from broiler flocks Resistênciaantimicrobiana em Campylobacter spp isoladas de frangos de corte', Brazilian Journal of Microbiologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000400026. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ceftriaxone and spectinomycin were active against all isolates in vitro.
Po-Lin Chen, Hsin-Chun Lee, Jing-Jou Yan, Yu-Hsiang Hsieh, Nan-Yao Lee, Nai-Ying Ko,Chia-Wei Lin, Chia-Ming Chang, Chi-Jung Wu, Ching-Chi Lee, Wen-Chien Ko 2010, 'High Prevalence of Mutations in Quinolone-resistance-determining Regions and mtrRLoci in Polyclonal Neisseria gonorrhoeae Isolates at a Tertiary Hospital in SouthernTaiwan', Journal of the Formosan Medical Associationhttp://www.sciencedirect.com/science/article/pii/S0929664610600320. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Homologous recombination between repeated copies of incomplete spectinomycin resistance genes results in the restoration of spectinomycin resistance.
Luka Bočkor, Srećko Jelenić†, Nenad Malenica, Jelena Mlinarec, Višnja Besendorfer,Ivana Ivančić-Baće 2013, 'Comparison of Intraplasmid Rearrangements in Agrobacterium tumefaciens and Escherichiacoli', Food Technology and Biotechnologyhttp://hrcak.srce.hr/file/169393. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The antibiotics used were rifampicin and either streptomycin or spectinomycin basedon antibiotic profiles of the donor and recipients.
Edi Husen 2013, 'THE USE OF gusA REPORTER GENE TO MONITOR THE SURVIVAL OF INTRODUCED BACTERIA IN THESOIL', Indonesian Journal of Agricultural Sciencehttp://ejurnal.litbang.pertanian.go.id/index.php/ijas/article/view/641. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)