In the spleen, several sclerosiderosis foci, subcortical chronic hemorrhage, and acute supurative splenitis were found.
María S González D, Liliana Fernández, Sandra Saldarriaga, Diego Aranzazu, Juan GMaldonado E 2005, 'Infertilidad en una perra con historia de falla reproductiva recurrente asociada contumor de células de la granulosa Infertility in a bitch with history of recurrentreproductive failure associated with granulose cell tumor', Revista Colombiana de Ciencias Pecuariashttp://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-06902005000300007. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Postmortem examination and microscopical findings revealed hepatitis with basophilic intranuclear inclusion, splenitis, myocarditis, and nephritis.
Asok Kumar Mariappan, Palanivelu Munusamy, Shyma K. Latheef, Shambu Dayal Singh, KuldeepDhama 2018, 'Hepato nephropathology associated with inclusion body hepatitis complicated with citrininmycotoxicosis in a broiler farm', Veterinary Worldhttp://www.veterinaryworld.org/Vol.11/February-2018/3.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hepatitis, splenitis and inflammation of non-primed joints were observed as systemic side effects.
Imke Rudnik-Jansen, Nina Woike, Suzanne de Jong, Sabine Versteeg, Marja Kik, PieterEmans, George Mihov, Jens Thies, Niels Eijkelkamp, Marianna Tryfonidou, Laura Creemers 2019, 'Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing ofDrug Delivery Systems', Pharmaceuticshttps://www.mdpi.com/1999-4923/11/2/70. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Curiously, both a splenitis of the cranial and fibrosis of the caudal portions of the spleen were found.
María S González D, Liliana Fernández, Sandra Saldarriaga, Diego Aranzazu, Juan GMaldonado E 2005, 'Infertilidad en una perra con historia de falla reproductiva recurrente asociada contumor de células de la granulosa Infertility in a bitch with history of recurrentreproductive failure associated with granulose cell tumor', Revista Colombiana de Ciencias Pecuariashttp://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-06902005000300007. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Other complications included severe splenitis (p<0.001) and hepatitis (p<0.001) which were normalized with combination therapy.
Helieh S Oz 2014, 'Toxoplasmosis Complications and Novel Therapeutic Synergism Combination of Diclazurilplus Atovaquone', Frontiers in Microbiologyhttp://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00484/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)