a white, crystalline nucleoside, C10H13N5O5, condensed from guanine and ribose: it is a major component of RNA
guanosine in American English
(ˈɡwɑːnəˌsin, -sɪn)
noun
Biochemistry
a ribonucleoside component of ribonucleic acid, comprising ribose and guanine
Word origin
[1905–10; guan(ine) + -ose + -ine2]This word is first recorded in the period 1905–10. Other words that entered Englishat around the same time include: Expressionism, scrounge, stabilizer, thiamine, white list-ine is a suffix, of no assignable meaning, appearing in nouns of Greek, Latin, or Frenchorigin. Other words that use the affix -ine include: doctrine, famine, routine
Examples of 'guanosine' in a sentence
guanosine
Guanosine was administered immediately, 1 h, 3 h and 6 h after surgery.
Gisele Hansel, Denise Barbosa Ramos, Camila Aguilar Delgado, Débora Guerini Souza,Roberto Farina Almeida, Luis Valmor Portela, André Quincozes-Santos, Diogo OnofreSouza 2014, 'The potential therapeutic effect of guanosine after cortical focal ischemia in rats.',PLoS ONEhttp://europepmc.org/articles/PMC3938812?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Spread of human platelets on collagen in the presence of guanosine was fully inhibited.
Iván Palomo, Claudio Valenzuela, Margarita Gutiérrez, Luis Astudillo, Marcelo Alarcón,Eduardo Fuentes 2013, 'Protective Mechanisms of Guanosine from Solanum lycopersicum on Agonist-Induced PlateletActivation: Role of sCD40L', Moleculeshttp://www.mdpi.com/1420-3049/18/7/8120. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, the presence of 8-substituted guanosine derivatives decreased mismatch discrimination.
Daniel Sylwester Baranowski, Weronika Kotkowiak, Ryszard Kierzek, Anna Pasternak 2015, 'Hybridization Properties of RNA Containing 8-Methoxyguanosine and 8-Benzyloxyguanosine.',PLoS ONEhttp://europepmc.org/articles/PMC4564172?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The concentration of cavernous cyclic guanosine monophosphate was detected by enzyme-linked immunosorbent assay.
Zhang-Yan Zhou, Guang-Jun Zhong, Shao-Ping Cheng, Hui Huang, Jing Wang, Hui Pan, Chang-MaoLiu, Cheng Xing, Ya-Ling Sun, Rong-Hua Liu, Fei-Li 2016, 'Short hairpin RNA targeting insulin-like growth factor binding protein-3 restoresthe bioavailability of insulin-like growth factor-1 in diabetic rats', International Brazilian Journal of Urologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382016000100139&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The probe exhibited a good selectivity to adenosine against its analogs (uridine, guanosine, and cytidine).
Yingying Hu, Jingjing Liu, Xiangyu You, Can Wang, Zhen Li, Weihong Xie 2017, 'A Light-Up Probe for Detection of Adenosine in Urine Samples by a Combination of anAIE Molecule and an Aptamer', Sensorshttps://www.mdpi.com/1424-8220/17/10/2246. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Decreased adenine and guanosine and increased inosine and uridine suggested perturbed nucleotide metabolism.
Amrita K Cheema, Shubhankar Suman, Prabhjit Kaur, Rajbir Singh, Albert J Fornace,Kamal Datta 2014, 'Long-term differential changes in mouse intestinal metabolomics after γ and heavyion radiation exposure.', PLoS ONEhttp://europepmc.org/articles/PMC3903607?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Further examination showed that the interaction effect of aging and genotype only disturbed the guanosine levels.
Xi Chen, Chengsong Xie, Lixin Sun, Jinhui Ding, Huaibin Cai 2015, 'Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53TTransgenic Mice.', PLoS ONEhttp://europepmc.org/articles/PMC4552665?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Treatment with guanosine restored these parameters.
Gisele Hansel, Denise Barbosa Ramos, Camila Aguilar Delgado, Débora Guerini Souza,Roberto Farina Almeida, Luis Valmor Portela, André Quincozes-Santos, Diogo OnofreSouza 2014, 'The potential therapeutic effect of guanosine after cortical focal ischemia in rats.',PLoS ONEhttp://europepmc.org/articles/PMC3938812?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The elucidation of these structures furnishes an explanation to the physical behaviour of guanosine units which display organogelator properties.
Paolo Neviani, Dominique Sarazin, Marc Schmutz, Christian Blanck, Nicolas Giuseppone,Gian Piero Spada 2010, 'Hierarchical Formation of Fibrillar and Lamellar Self-Assemblies from Guanosine-BasedMotifs', Journal of Nucleic Acidshttp://dx.doi.org/10.4061/2010/938536. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
For all tested compounds, coumarin conjugates with 4-thiouridine, pseudouridine, guanosine, and uridine were identified, with thelatter largely dominating.
Stefanie Kellner, Laura Bettina Kollar, Antonia Ochel, Manjunath Ghate, Mark Helm 2013, 'Structure-function relationship of substituted bromomethylcoumarins in nucleosidespecificity of RNA alkylation.', PLoS ONEhttp://europepmc.org/articles/PMC3700928?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)