reversion of plant or animal cells to a simpler less differentiated form
anaplasia in American English
(ˌænəˈpleiʒə, -ʒiə, -ziə)
noun
Pathology
the loss of structural differentiation within a cell or group of cells
Word origin
[1905–10; ana- + -plasia]This word is first recorded in the period 1905–10. Other words that entered Englishat around the same time include: Expressionism, airway, overcall, scrounge, stabilizerana- is a prefix in loanwords from Greek, where it means “up,” “against,” “back,” “re-”(anabasis); used in the formation of compound words. Other words that use the affix ana- include: anapest, anatomy, antanaclasis, epanalepsis, epanodos; -plasia is a combining form with the meaning “growth, cellular multiplication,” of the kindspecified by the initial element. Other words that use the affix -plasia include: achondroplasia, cataplasia, heteroplasia, homeoplasia, hypoplasia
Examples of 'anaplasia' in a sentence
anaplasia
Anaplasia parameters did not correlate well with tumor invasion of deeper tissues and mitotic counts.
Gabrielle A. Fornazari, Juliana Kravetz, Matti Kiupel, Dodd Sledge, Ivan Roque DeBarros Filho, Fabiano Montiani-Ferreira 2017, 'Ocular squamous cell carcinoma in Holstein cows from the South of Brazil', Veterinary Worldhttp://www.veterinaryworld.org/Vol.10/December-2017/2.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The tumor consisted of malignant epithelioid and spindle cells with marked anaplasia.
Tadashi Terada, M.D., Ph.D. 2015, 'Proximal-type epithelioid sarcoma of pharynx: A case report with immunohistochemicalstudy', Human Pathology: Case Reportshttp://www.sciencedirect.com/science/article/pii/S2214330014200344. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The results reinforce the hypotheses that in the presence of anaplasia adverse events may occur simultaneously in this neoplasm.
Maria Teresa de Seixas Alves, Luciana Nakao Odashiro Miiji, Larissa Cardoso Marinho,Antonio Sergio Petrilli, Reynaldo Jesus-Garcia, Silvia Caminada Tolledo, Francy Reisda Silva Patricio 2008, 'Osteossarcomas humanos de alto grau: imunoexpressão de p53, erb-2 e P-glicoproteína,e correlação com o parâmetro anaplasia P-glycoprotein, erb2 and p53 expression inhigh-grade human osteosarcomas and their correlation with anaplasia', Jornal Brasileiro de Patologia e Medicina Laboratorialhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442008000200007. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
For distinguishing the minor malignancy cases from others, histological findings such as myoepithelial anaplasia could be a predictive factor.
Yasuhiro Nakashima, Riichiro Morita, Akiko Ui, Kuniko Iihara, Takuya Yazawa 2018, 'Epithelial-myoepithelial carcinoma of the lung: a case report', Surgical Case Reportshttp://link.springer.com/article/10.1186/s40792-018-0482-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They are considered benign based off their low mitotic activity, lack of anaplasia or necrosis, and limited vascularization.
Emily Barber, Ann Eapen, Rita Mehta, Erin Lin, Karen Lane, Yu Cheng, Ritesh Parajuli 2019, 'Benign Metastasizing Leiomyoma to the Lung and Spine: A Case Report and LiteratureReview', Case Reports in Oncologyhttps://www.karger.com/Article/FullText/496333. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The survival rate was 89.4% for patients with favorable histology, 66.7% for focal anaplasia and 40% for diffuse anaplasia.
Marilia Fornaciari Grabois, Gulnar Azevedo e Silva Mendonça 2005, 'Prognóstico de pacientes com tumor de Wilms unilateral no Rio de Janeiro, 1990-2000Prognosis for patients with unilateral Wilms' tumor in Rio de Janeiro, Brazil, 1990-2000',Revista de Saúde Públicahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102005000500006. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Despite their ability to metastasize, they are considered to be benign due to the lack of anaplasia.
Anna M. Ponea, Creticus P. Marak, Harmeen Goraya, Achuta K. Guddati 2013, 'Benign Metastatic Leiomyoma Presenting as a Hemothorax', Case Reports in Oncological Medicinehttp://dx.doi.org/10.1155/2013/504589. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This study also revealed the occurrence of many tumors with anaplasia and pronounced infiltrative features, but which did not metastasize.
Paulo Vargas Peixoto, Ticiana do Nascimento França, Claudio S.L. Barros, Carlos HubingerTokarnia 2003, 'Histopathological aspects of Bovine Enzootic Hematuria in Brazil Aspectos histopatológicosda Hematúria Enzoótica Bovina no Brasil', Pesquisa Veterinária Brasileirahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2003000200004. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Multiple primary ependymomatous lesions were seen on magnetic resonance imaging and no anaplasia was identified on the surgical-pathological analysis.
Kaliaperumal Chandrasekaran, Suttner Nigel, Herron Brian, Choudhari Kishor A 2009, 'Rare case of primary spinal ependymomatosis occurring in a 26-year-old man: a casereport', Journal of Medical Case Reportshttp://www.jmedicalcasereports.com/content/3/1/72. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)