an antibiotic often prescribed to be taken with a sulphonamide, esp to treat urinary infections
trimethoprim in American English
(traiˈmeθəprɪm)
noun
Pharmacology
a synthetic crystalline compound, C11H18N4O3, usually combined with a sulfonamide as an antibiotic preparation in the treatment of urinary tract infections and pneumocystis pneumonia
Word origin
[1960–65; trimetho(xyphenyl) + p(y)rim(idinediamine), components of its chemical name]This word is first recorded in the period 1960–65. Other words that entered Englishat around the same time include: Pap test, go-go, parvovirus, proxemics, tag question
Examples of 'trimethoprim' in a sentence
trimethoprim
Side effects occurred only in the trimethoprim-sulfamethoxazole group.
Roberto Fiolic Alvarez, Angelo Alves de Mattos, Esther Buzaglo Dantas Corrêa, HelmaPinchemel Cotrim, Tereza Virginia S. B. Nascimento 2005, 'Trimethoprim-sulfamethoxazole versus norfloxacin in the prophylaxis of spontaneousbacterial peritonitis in cirrhosis Trimetoprima-sulfametoxazol versus norfloxacinona profilaxia da peritonite bacteriana espontânea na cirrose', Arquivos de Gastroenterologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032005000400012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cephalosporins, clindamycin, amoxicillin/clavulanate, penicillin, vancomycin, and trimethoprim/sulfamethoxazole were major antibiotic choices.
Tolga Türker, Nicole Capdarest-Arest, Spencer T. Bertoch, Erik C. Bakken, Susan E.Hoover, Jiyao Zou 2014, 'Hand infections: a retrospective analysis', PeerJhttps://peerj.com/articles/513.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All isolates were susceptible to trimethoprim-sulfametoxazole and were resistant to most beta-lactams tested.
Garcia Doroti de Oliveira, Timenetsky Jorge, Martinez Marina Baquerizo, FranciscoWaldemar, Sinto Sumiko I., Yanaguita Roberto Mitio 2002, 'Proteases (caseinase and elastase), hemolysins, adhesion and susceptibility to antimicrobialsof Stenotrophomonas maltophilia isolates obtained from clinical specimens', Brazilian Journal of Microbiologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000200012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Resistance to ampicillin and trimethoprim/sulfamethoxazole was highly prevalent (>65%).
Jessica Couvillion Seidman, Lashaunda Brooke Johnson, Joshua Levens, Harran Mkocha,Beatriz Muñoz, Ellen K Silbergeld, Sheila K West, Christian L Coles 2016, 'Longitudinal Comparison of Antibiotic Resistance in Diarrheagenic and Non-pathogenicE. coli from Young Tanzanian Children', Frontiers in Microbiologyhttp://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01420/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All strains were susceptible to trimethoprim-sulfamethoxazole, gentamicin, rifampin, ofloxacin,streptomycin, doxycycline, and ciprofloxacin.
Joldoshbek Kasymbekov, Joldoshbek Imanseitov, Marie Ballif, Nadia Schürch, SandraPaniga, Paola Pilo, Mauro Tonolla, Cinzia Benagli, Kulyash Akylbekova, Zarima Jumakanova,Esther Schelling, Jakob Zinsstag 2013, 'Molecular epidemiology and antibiotic susceptibility of livestock Brucella melitensisisolates from Naryn Oblast, Kyrgyzstan.', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC3584998?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The treatment with pyrimethamine and trimethoprim-sulfamethoxazole led to complete resolution of skin lesions.
Marina Sonya, Broshtilova Valja, Botev Ivo, Guleva Dimitrina, Hadzhiivancheva Maria,Nikolova Assia, Kazandjieva Jana 2014, 'Cutaneous Manifestations of Toxoplasmosis: a Case Report', Serbian Journal of Dermatology and Venereologyhttp://www.degruyter.com/view/j/sjdv.2014.6.issue-3/sjdv-2014-0010/sjdv-2014-0010.xml?format=INT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Five-year hospital and community resistance rates were highest for ampicillin (41.9%) and trimethoprim (20.7%).
Oyebola Fasugba, Brett G Mitchell, George Mnatzaganian, Anindita Das, Peter Collignon,Anne Gardner 2016, 'Five-Year Antimicrobial Resistance Patterns of Urinary Escherichia coli at an AustralianTertiary Hospital: Time Series Analyses of Prevalence Data.', PLoS ONEhttp://europepmc.org/articles/PMC5053592?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The most common antimicrobials prescribed were amoxicillin (38% of cases), trimethoprim(30%) and flucloxacillin (27%).
Jiafeng Pan, Kim Kavanagh, Charis Marwick, Camilla Wuiff, Peter Davey, Scott Bryson,Chris Robertson, Marion Bennie 2017, 'Investigating antimicrobial prescribing pattern before the development of CDI usingdata linkage', International Journal of Population Data Sciencehttps://ijpds.org/article/view/312. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The majority of the isolates demonstrated resistance to tetracyclines, sulfanilamides and trimethoprim.
A. V. Potekhin, V. S. Rusaleyev 2018, 'Monitoring of antibiotic resistance of Acinobacillus pleuropneumoniae isolated inthe Russian Federation in 2012-2014', Ветеринария сегодняhttps://veterinary.arriah.ru/jour/article/view/228. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)