[1915–20; tri- + nucleotide]This word is first recorded in the period 1915–20. Other words that entered Englishat around the same time include: conditioning, decoder, neorealism, soviet, takeouttri- is a combining form meaning “three,” used in the formation of compound words. Otherwords that use the affix tri- include: triathlon, trigeminal, triglyph, trio, trivial
Examples of 'trinucleotide' in a sentence
trinucleotide
The bias at trinucleotide level was on average low.
Andrea Porceddu, Salvatore Camiolo 2011, 'Spatial Analyses of Mono, Di and Trinucleotide Trends in Plant Genes', PLoS ONE10.1371/journal.pone.0022855. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Expanded trinucleotide repeat sequences are the cause of several inherited neurodegenerative diseases.
Rebecka L Bourn, Irene De Biase, Ricardo Mouro Pinto, Chiranjeevi Sandi, Sahar Al-Mahdawi,Mark A Pook, Sanjay I Bidichandani 2012, 'Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues.',PLoS ONEhttp://europepmc.org/articles/PMC3469490?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our study demonstrates that a certain trinucleotide repeat influences normal brain structure in humans.
Mark Mühlau, Juliane Winkelmann, Dan Rujescu, Ina Giegling, Nikolaos Koutsouleris,Christian Gaser, Milan Arsic, Adolph Weindl, Maximilian Reiser, Eva M. Meisenzahl 2012, 'Variation within the Huntington's Disease Gene Influences Normal Brain Structure',PLoS ONE10.1371/journal.pone.0029809. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The loci amplified di- and trinucleotide repeats with 3–14 alleles per locus.
Jeremie B. Fant, Hannah Weinberg-Wolf, David C. Tank, Krissa A. Skogen 2013, 'Characterization of Microsatellite Loci in Castilleja sessiliflora and Transferabilityto 24 Castilleja Species (Orobanchaceae)', Applications in Plant Scienceshttp://www.bioone.org/doi/full/10.3732/apps.1200564. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The primers amplified di- and trinucleotide repeats with 1–8 alleles per locus.
Alicia Agudo, F. Xavier Picó, Inés Álvarez 2013, 'Microsatellite Primers in the Weedy Annual Herb Anacyclus clavatus (Asteraceae)and Four Closely Related Species', Applications in Plant Scienceshttp://www.bioone.org/doi/full/10.3732/apps.1300043. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Rare fragile sites are the archetypal trinucleotide repeats.
Rajesh Kumar, Gandharva Nagpal, Vinod Kumar, Salman Sadullah Usmani, Piyush Agrawal,Gajendra P. S. Raghava 2019, 'HumCFS: a database of fragile sites in human chromosomes', BMC Genomicshttp://link.springer.com/article/10.1186/s12864-018-5330-5. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Trinucleotide repeat expansions are responsible for more than two dozens severe neurological disorders in humans.
Guy-Franck Richard, David Viterbo, Varun Khanna, Valentine Mosbach, Lauriane Castelain,Bernard Dujon 2014, 'Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN inyeast.', PLoS ONEhttp://europepmc.org/articles/PMC3991675?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Trinucleotide repeats can be highly unstable, mutating far more frequently than point mutations.
Beatriz A Santillan, Christopher Moye, David Mittelman, John H Wilson 2014, 'GFP-based fluorescence assay for CAG repeat instability in cultured human cells.',PLoS ONEhttp://europepmc.org/articles/PMC4244167?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The primers amplified di- and trinucleotide repeats with four to 27 alleles per locus.
Gustavo H. F. Klabunde, Denise Olkoski, Vinicius Vilperte, Maria I. Zucchi, RubensO. Nodari 2014, 'Characterization of 10 New Nuclear Microsatellite Markers in Acca sellowiana(Myrtaceae)', Applications in Plant Scienceshttp://www.bioone.org/doi/full/10.3732/apps.1400020. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)