a proteolytic enzyme that causes fibrinolysis in blood clots
plasmin in American English
(ˈplæzmɪn)
noun
a proteolytic enzyme, derived from substances in the blood plasma, that slowly dissolves blood clots
Word origin
plasma + -in1
Examples of 'plasmin' in a sentence
plasmin
The plasmin enzymatic activity was determined by a turbidimetric assay and a chromogenic substrate-based assay.
Yusova E. I. 2015, 'Plasmin enzymatic activity in the presence of actin', Biopolymers and Cellhttp://biopolymers.org.ua/pdf/31/5/345/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, actin did not impede plasmin autolysis and had no influence on its amidase activity.
Yusova E. I. 2015, 'Plasmin enzymatic activity in the presence of actin', Biopolymers and Cellhttp://biopolymers.org.ua/pdf/31/5/345/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This was attributed to plasmin causing disintegration of formed platelet aggregates.
Satu Hyvärinen, T. Sakari Jokiranta 2015, 'Minor Role of Plasminogen in Complement Activation on Cell Surfaces', PLOS ONE10.1371/journal.pone.0143707. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In separate experiments, incubation with plasmin did not directly activate neutrophils.
Christoph A Reichel, Max Lerchenberger, Bernd Uhl, Markus Rehberg, Nina Berberich,Stefan Zahler, Matthias P Wymann, Fritz Krombach 2011, 'Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemicmicrovasculature.', PLoS ONEhttp://europepmc.org/articles/PMC3043096?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Overall, our work presents the first small, synthetic allosteric plasmin inhibitors for further rational design.
Rami A. Al-Horani, Rajesh Karuturi, Domonique T. White, Umesh R. Desai 2015, 'Plasmin Regulation through Allosteric, Sulfated, Small Molecules', Moleculeshttp://www.mdpi.com/1420-3049/20/1/608. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Instead of inducing fibronectin expression, plasmin however reduced mesangial fibronectin deposition in vitro.
Maaike Waasdorp, JanWillem Duitman, C. Arnold Spek 2017, 'Plasmin reduces fibronectin deposition by mesangial cells in a protease-activatedreceptor-1 independent manner', Biochemistry and Biophysics Reportshttp://www.sciencedirect.com/science/article/pii/S2405580816303569. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Among the most studied proteases are furin, prostasin, elastase, plasmin and trypsin.
Luciano Galizia, Alejandro Ojea, Basilio A. Kotsias 2011, 'Regulación por proteasas del canal de sodio sensible al amiloride (ENaC) Amiloridesensitive sodium channels (ENaC) and their regulation by proteases', Medicina (Buenos Aires)http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802011000200015. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Addition of aprotinin and soybean tripsin inhibitors in milk inhibits plasmin activity.
Samir Kalit, Jasmina Lukač Havranek, Vlatka Čubrić Ćurik 2002, 'Plasmin: indigenous milk proteinase', Mljekarstvohttp://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=3546. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This model includes the important fibrinogen interactions that stimulate plasmin generation.
Sian Huish, Craig Thelwell, Colin Longstaff 2017, 'Activity Regulation by Fibrinogen and Fibrin of Streptokinase from Streptococcus Pyogenes',PLOS ONE10.1371/journal.pone.0170936. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)