having a single extra chromosome in the cell in addition to the normal diploid number
noun
2.
a trisomic cell or organism
Derived forms
trisomy (triˈsomy) (traɪˌsoʊmi)
noun
Word origin
tri- + -some3 + -ic
trisomic in American English
(traiˈsoumɪk)
adjective
Genetics
having one chromosome in addition to the usual diploid number
Word origin
[trisome + -ic]-ic is a suffix forming adjectives from other parts of speech, occurring originally inGreek and Latin loanwords (metallic; poetic; archaic; public) and, on this model, used as an adjective-forming suffix with the particular senses“having some characteristics of” (opposed to the simple attributive use of the basenoun) (balletic; sophomoric); “in the style of” (Byronic; Miltonic); “pertaining to a family of peoples or languages” (Finnic; Semitic; Turkic)
Examples of 'trisomic' in a sentence
trisomic
It caused an amputation of the distal phalanx of the thumb in a trisomic patient.
A. Maleb, J. Elmalki, O. Bouayadi, Y. Ben Lahlou, M. Frikh, N. Abdeljaouad, A. Lemnouer,H. Yacoubi, M. Elouennass 2018, 'Serious phlegmonous lesion of the hand following an injury by vegetal thorn: Neverforget Pasteurella multocida!', Trauma Case Reportshttp://www.sciencedirect.com/science/article/pii/S2352644017300730. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hsa21 gene expression was globally upregulated 1.5 fold in trisomic samples.
Olla Carlo, D'Armiento Maria, Genesio Rita, Greco Dario, Negri Rosa, D'Agostino Paola,Fabbrini Floriana, Conti Anna, Paladini Dario, Zannini Mariastella, Nitsch Lucio 2007, 'Altered expression of mitochondrial and extracellular matrix genes in the heart ofhuman fetuses with chromosome 21 trisomy', BMC Genomicshttp://www.biomedcentral.com/1471-2164/8/268. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We confirmed increased expression of genes located at the trisomic chromosomal region.
Jeroen L A Pennings, Wendy Rodenburg, Sandra Imholz, Maria P H Koster, Conny T M vanOostrom, Timo M Breit, Peter C J I Schielen, Annemieke de Vries 2011, 'Gene expression profiling in a mouse model identifies fetal liver- and placenta-derivedpotential biomarkers for Down Syndrome screening.', PLoS ONEhttp://europepmc.org/articles/PMC3077415?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Gene expression analysis of cultured keratinocytes revealed upregulation of several trisomic and disomic genes may contribute to this hyperproliferation.
Annan Yang, Duane Currier, Jennifer L Poitras, Roger H Reeves 2016, 'Increased Skin Tumor Incidence and Keratinocyte Hyper-Proliferation in a Mouse Modelof Down Syndrome.', PLoS ONEhttp://europepmc.org/articles/PMC4708994?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They are seen commonly in cancer, embryonic stem cells, human embryos, and in various trisomic diseases.
Jonathan A. Griffiths, Antonio Scialdone, John C. Marioni 2017, 'Mosaic autosomal aneuploidies are detectable from single-cell RNAseq data', BMC Genomicshttp://link.springer.com/article/10.1186/s12864-017-4253-x. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This gave an overall frequency of triploid and putatively trisomic individuals in the data set of 0.017 and 0.083% respectively.
Katarina M Jørgensen, Vidar Wennevik, Anne Grete Eide Sørvik, Laila Unneland, SergeyPrusov, Fernando Ayllon, Kevin A Glover 2018, 'Investigating the frequency of triploid Atlantic salmon in wild Norwegian and Russianpopulations', BMC Geneticshttp://link.springer.com/article/10.1186/s12863-018-0676-x. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In trisomic offspring, non-disjunction may result in the reduction to homozygosity of a susceptibility allele inherited from a heterozygous parent.
Debarati Ghosh, Swagata Sinha, Anindita Chatterjee, Krishnadas Nandagopal 2009, 'A Study of GluK1 Kainate Receptor Polymorphisms in Down Syndrome Reveals Allelic Non-Disjunctionat 1173(C/T)', Disease Markershttp://dx.doi.org/10.3233/DMA-2009-0647. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Proteomic analysis showed significant alterations of the molecular composition of subsynaptic compartments of hippocampal trisomic neurons.
Macarena Gómez de Salazar, Cristina Grau, Francisco Ciruela, Xavier Altafaj 2018, 'Phosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampusof the Ts65Dn Mouse Model of Down Syndrome', Frontiers in Molecular Neurosciencehttps://www.frontiersin.org/article/10.3389/fnmol.2018.00226/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)