the condition in which a single gene exerts simultaneous effects on more than one character in the offspring
: also pleiˈotroˌpism
Derived forms
pleiotropic (ˌpleioˈtropic) (ˌplaɪoʊˈtrɑpɪk)
adjective
pleiotropically (ˌpleioˈtropically)
adverb
Word origin
pleio- + -tropy
pleiotropy in American English
(plaiˈɑtrəpi)
noun
Genetics
the phenomenon of one gene being responsible for or affecting more than one phenotypic characteristic
Derived forms
pleiotropic (ˌplaiəˈtrɑpɪk, -ˈtroupɪk)
adjective
pleiotropically
adverb
Word origin
[1935–40; pleio- + -tropy]This word is first recorded in the period 1935–40. Other words that entered Englishat around the same time include: Rhodesian ridgeback, blitz, gangbuster, hard core, roomette
Examples of 'pleiotropy' in a sentence
pleiotropy
This high degree of functional pleiotropy would then be ultimately responsible for the metastatic phenotype.
Franklin D. Rumjanek 2018, 'Osmolyte Induced Tumorigenesis and Metastasis: Interactions With Intrinsically DisorderedProteins', Frontiers in Oncologyhttps://www.frontiersin.org/article/10.3389/fonc.2018.00353/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This could be a function of shared genes leading to pleiotropy.
Kanduri Kartiek, Barrenas Fredrik, Chavali Sreenivas, Benson Mikael 2010, 'Network properties of human disease genes with pleiotropic effects', BMC Systems Biologyhttp://www.biomedcentral.com/1752-0509/4/78. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These findings may provide an important entry point to unravel genetic pleiotropy in obesity traits.
Yili Wu, Haiping Duan, Haiping Duan, Xiaocao Tian, Chunsheng Xu, Chunsheng Xu, WeijingWang, Wenjie Jiang, Zengchang Pang, Dongfeng Zhang, Qihua Tan, Qihua Tan 2018, 'Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis', Frontiers in Geneticshttp://journal.frontiersin.org/article/10.3389/fgene.2018.00179/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This suggested either potential pleiotropy or close linkage of minor factors influencing all three traits.
Sarah Hatzig, Frank Breuer, Nathalie Nesi, Sylvie Ducournau, Marie-Helene Wagner,Gunhild Leckband, Amine Abbadi, Rod J. Snowdon 2018, 'Hidden Effects of Seed Quality Breeding on Germination in Oilseed Rape (Brassica napusL.)', Frontiers in Plant Sciencehttp://journal.frontiersin.org/article/10.3389/fpls.2018.00419/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Common study limitations include low statistical power, potential pleiotropy, and risk of collider bias.
Marilyn C. Cornelis, Marcus R. Munafo 2018, 'Mendelian Randomization Studies of Coffee and Caffeine Consumption', Nutrientshttp://www.mdpi.com/2072-6643/10/10/1343. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Finally, the genetic correlation between systolic and diastolic blood pressure was 0.74, indicating incomplete pleiotropy.
Ginevra Biino, Gianfranco Parati, Maria Pina Concas, Mauro Adamo, Andrea Angius, AndreaAngius, Simona Vaccargiu, Mario Pirastu 2013, 'Environmental and genetic contribution to hypertension prevalence: data from an epidemiologicalsurvey on Sardinian genetic isolates.', PLoS ONEhttp://europepmc.org/articles/PMC3603911?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We found significant polygenic pleiotropy between the blood lipids and all the investigated immune-mediated diseases.
Ole A. Andreassen, Rahul S. Desikan, Yunpeng Wang, Wesley K. Thompson, Andrew J. Schork,Verena Zuber, Nadezhda T. Doncheva, Eva Ellinghaus, Mario Albrecht, Morten Mattingsdal,Andre Franke, Benedicte A. Lie, Ian Mills, Pål Aukrust, Linda K. McEvoy, Srdjan Djurovic,Tom H. Karlsen, Anders M. Dale 2015, 'Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases IndicatesShared Molecular Genetic Mechanisms', PLOS ONE10.1371/journal.pone.0123057. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Additionally, some loci can simultaneously regulate several complex traits, a phenomenon defined as pleiotropy.
Pablo Augusto de Souza Fonseca, Samir Id-Lahoucine, Antonio Reverter, Juan F. Medrano,Marina S. Fortes, Joaquim Casellas, Filippo Miglior, Luiz Brito, Maria Raquel S. Carvalho,Flávio S. Schenkel, Loan T. Nguyen, Laercio R. Porto-Neto, Milton G. Thomas, AngelaCánovas 2018, 'Combining multi-OMICs information to identify key-regulator genes for pleiotropiceffect on fertility and production traits in beef cattle', PLOS ONE10.1371/journal.pone.0205295. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In others, pleiotropy, when a gene can produce several phenotypic traits, may be involved.
Noveski P., Mircevska M., Plaseski T., Peterlin B., Plaseska-Karanfilska D. 2014, 'Study of Three Single Nucleotide Polymorphisms in the Slc6a14 Gene in Associationwith Male Infertility', Balkan Journal of Medical Geneticshttp://www.degruyter.com/view/j/bjmg.2014.17.issue-2/bjmg-2014-0075/bjmg-2014-0075.xml?format=INT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Three-way analyses differentiated the pattern of pleiotropy among the immune-mediated diseases.
Ole A Andreassen, Rahul S Desikan, Yunpeng Wang, Wesley K Thompson, Andrew J Schork,Verena Zuber, Nadezhda T Doncheva, Eva Ellinghaus, Mario Albrecht, Morten Mattingsdal,Andre Franke, Benedicte A Lie, Ian G Mills, Pål Aukrust, Linda K McEvoy, Srdjan Djurovic,Tom H Karlsen, Anders M Dale 2015, 'Abundant genetic overlap between blood lipids and immune-mediated diseases indicatesshared molecular genetic mechanisms.', PLoS ONEhttp://europepmc.org/articles/PMC4390360?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)