Polysomy of chromosome 17 was also detected in tumor-adjacent epithelia.
Noemi MESZAROS, Dragoş BELENGEANU, Dorina STOICĂNESCU, Nicoleta ANDREESCU, SimonaFARCAŞ, Monica STOIAN, Mariana CEVEI 2010, 'Analyses of numerical aberrations of chromosome 17 and tp53 gene deletion/amplificationin human oral squamous cell carcinoma using dual-color fluorescence in situ hybridization',Analele Universitatii din Oradea: Fascicula Biologiehttp://www.bioresearch.ro/bioresearch/2010-1/142-146%20-%20MESZAROS%20N.%20-%20U.M.F.Tm%20-%20Analyses%20of%20numerical%20aberrations.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Nineteen percent of the tumors showed chromosome 7 polysomy, and 16% showed chromosome 17polysomy.
Shi Xiaohua, Wang Peng, Wu Shafei, Gao Jie, Zeng Xuan, Liang Zhiyong, Zhang Jing,Liu Tonghua 2008, 'Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastricadenocarcinoma from Chinese patients', BMC Cancerhttp://www.biomedcentral.com/1471-2407/8/363. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
There were no mutations, with the majority of samples showing polysomy of chromosome 7.
Emanuela Boštjančič, Nina Hauptman, Aleš Grošelj, Damjan Glavač, Metka Volavšek 2017, 'Expression, Mutation, and Amplification Status of EGFR and Its Correlation with FivemiRNAs in Salivary Gland Tumours', BioMed Research Internationalhttp://dx.doi.org/10.1155/2017/9150402. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Genetic studies have demonstrated the presence of polysomy of chromosome 2 and chromosome 19q13.42 amplification.
Cleciton Braga Tavares, Francisca das Chagas Sheyla Almeida Gomes-Braga, Emerson BrandãoSousa, Camilla Aniele Areia Ferreira, José Nazareno Pearce de Oliveira Brito 2017, 'Embryonic Tumor with Abundant Neuroepithelium and True Rosettes (ETANTR): Case Reportand Literature Review', Brazilian Neurosurgeryhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1607358. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In three cases (42.8 %), the polysomy was observed.
Anna Scattone, Annamaria Catino, Laura Schirosi, Lucia Caldarola, Stefania Tommasi,Rosanna Lacalamita, Elisabetta Sara Montagna, Domenico Galetta, Gabriella Serio, FrancescoAlfredo Zito, Anita Mangia 2019, 'Discordance between FISH, IHC, and NGS Analysis of ALK Status in Advanced Non–SmallCell Lung Cancer (NSCLC): a Brief Report of 7 Cases', Translational Oncologyhttp://www.sciencedirect.com/science/article/pii/S1936523318304856. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Factor analysis of the data set extracted 3 intrinsic factors of variation, representing amplification, “polysomy”, and bimodality.
G. Radziuviene, Allan Rasmusson, R. Augulis, D. Lesciute-Krilaviciene, A. Laurinaviciene,E. Clim, Arvydas Laurinavicius 2016, 'Automated Image Analysis Of Her2 Fish Enables New Definitions Of Genetic HeterogeneityIn Breast Cancer Tissue', Diagnostic Pathologyhttp://www.diagnosticpathology.eu/content/index.php/dpath/article/view/155. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Epidermal growth factor receptor was overexpressed and fluorescence in situ hybridization analysis demonstrated a chromosome 7 polysomy.
Grisanti Salvatore, Amoroso Vito, Buglione Michela, Rosati Anna, Gatta Roberto, PizzocaroClaudio, Ferrari Vittorio D, Marini Giovanni 2008, 'Cetuximab in the treatment of metastatic mucoepidermoid carcinoma of the salivaryglands: A case report and review of literature', Journal of Medical Case Reportshttp://www.jmedicalcasereports.com/content/2/1/320. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Because of this incomplete polysomy, multiple-dose markers could not be mapped for lack of a genetic model for their segregation.
Guimarães Claudia T., Honeycutt Rhonda J., Sills Gavin R., Sobral Bruno W.S. 1999, 'Genetic maps of Saccharum officinarum L. and Saccharum robustum Brandes & Jew. exgrassl', Genetics and Molecular Biologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000100024. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
80 % of cases presented chromosome 17 polysomy and only 20% of cases had chromosome17 monosomy.
Noemi MESZAROS, Dragoş BELENGEANU, Dorina STOICĂNESCU, Nicoleta ANDREESCU, SimonaFARCAŞ, Monica STOIAN, Mariana CEVEI 2010, 'Analyses of numerical aberrations of chromosome 17 and tp53 gene deletion/amplificationin human oral squamous cell carcinoma using dual-color fluorescence in situ hybridization',Analele Universitatii din Oradea: Fascicula Biologiehttp://www.bioresearch.ro/bioresearch/2010-1/142-146%20-%20MESZAROS%20N.%20-%20U.M.F.Tm%20-%20Analyses%20of%20numerical%20aberrations.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Associated with these changes was an increase in karyotypic entropy, evident by the accumulation of chromosomal aberrations and polysomy.
Kazunori Namiki, Steve Goodison, Stacy Porvasnik, Robert W Allan, Kenneth A Iczkowski,Cydney Urbanek, Leticia Reyes, Noboru Sakamoto, Charles J Rosser 2009, 'Persistent exposure to Mycoplasma induces malignant transformation of human prostatecells.', PLoS ONEhttp://europepmc.org/articles/PMC2730529?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)