(of a drug, agent, activity, etc) effective in killing trypanosomes
Examples of 'trypanocidal' in a sentence
trypanocidal
Upon evaluating the combination of both compounds, and additive trypanocidal effect was observed.
Valeria P. Sülsen, Vanesa Puente, Daniela Papademetrio, Alcira Batlle, Virginia S.Martino, Fernanda M. Frank, María E. Lombardo 2016, 'Mode of Action of the Sesquiterpene Lactones Psilostachyin and Psilostachyin C onTrypanosoma cruzi', PLOS ONE10.1371/journal.pone.0150526. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The trypanocidal activity seems to be increased by fractionation of the extracts.
Alessandra Regina Pepe Ambrozin, Paulo Cezar Vieira, João Batista Fernandes, MariaFátima das Graças Fernandes da Silva, Sérgio de Albuquerque 2004, 'Trypanocidal activity of Meliaceae and Rutaceae plant extracts', Memórias do Instituto Oswaldo Cruz.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200020. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our results suggest that mammea-type coumarins could be a valuable source of trypanocidal compounds.
Ricardo Reyes-Chilpa, Elizabeth Estrada-Muñiz, Elisa Vega-Avila, Fumiko Abe, JuneiKinjo, Simón Hernández-Ortega 2008, 'Trypanocidal constituents in plants: 7. Mammea-type coumarins', Memórias do Instituto Oswaldo Cruz.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000500004. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Trypanocidal activity of plants was assayed on epimastigote cultures in liver infusion tryptose.
Truiti M.C.T., Ferreira I.C.P., Zamuner M.L.M., Nakamura C.V., Sarragiotto M.H., SouzaM.C. 2005, 'Antiprotozoal and molluscicidal activities of five Brazilian plants', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200016. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our findings suggest a trypanocidal effect in the long-term follow-up.
Yanina Sguassero, Cristina B Cuesta, Karen N Roberts, Elizabeth Hicks, Daniel Comandé,Agustín Ciapponi, Sergio Sosa-Estani 2015, 'Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitologicaland Serological Tests: A Systematic Review of Follow-Up Studies.', PLoS ONEhttp://europepmc.org/articles/PMC4593559?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The new compounds exhibit moderate trypanocidal and anti-plasmodial activities.
Dieudonne Ngamga, Emmanuel Yankep, Pierre Tane, Merhatibeb Bezabih, Bonaventure T.Ngadjui, Z. Tanee Fomum, Berhanu M. Abegaz 2005, 'Antiparasitic prenylated isoflavonoids from seeds of Millettia griffoniana',Bulletin of the Chemical Society of Ethiopiahttp://www.ajol.info/index.php/bcse/article/view/21112. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Currently, specific trypanocidal therapy remains on benznidazole, although new triazole derivatives are promising.
Carolina Campos-Estrada, Ana Liempi, Fabiola González-Herrera, Michel Lapier, UlrikeKemmerling, Barbara Pesce, Jorge Ferreira, Rodrigo López-Muñoz, Juan D Maya 2015, 'Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced EndothelialActivation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin.', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC4433340?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The products are evaluated in vitro as trypanocidal agents.
H. Cerecetto, R. Di Maio, G. Seoane, C. Ochoa, S. Muelas, A. Gómez-Barrio 2000, 'Synthesis of 1,2,6-Thiadiazin 1,1-Dioxide Derivatives as Trypanocidal Agents', Moleculeshttp://www.mdpi.com/1420-3049/5/3/499/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The theoretical results were numerically compared to the trypanocidal activity.
A. F. C. Alcântara, D. Silveira, E. Chiari, A. B. Oliveira, J. E. Guimarães, D. S.Raslan 2005, 'Comparative analysis of the trypanocidal activity and chemical properties of E-lychnophoricacid and its derivatives using theoretical calculations Análise comparativa, por cálculosteóricos, da atividade tripanossomicida e das propriedades químicas do ácido E-licnofóricoe de seus derivados', Eclética Químicahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702005000300005. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, we were not able to detect any trypanocidal activity with these oxamates.
Miguel A Chena, Silvia Elizondo-Jiménez, Lorena Rodríguez-Páez, Benjamín Nogueda-Torres,Isabel Baeza-Ramírez, Carlos Wong-Ramírez 2004, 'Trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme II by N-allyland N-propyl oxamates and their effects on intact epimastigotes', Memórias do Instituto Oswaldo Cruz.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000800009. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)