a dark-brown or blackish hydroxide of heme, C34H32N4O4·FeOH, obtained by the decomposition of hemoglobin
Word origin
hemato- + -in1
hematin in American English
(ˈhimətɪn, ˈhemə-)
noun
1. Biochemistry
heme
2. (loosely)
hematein
Also: hematine
Word origin
[1810–20; hemat- + -in2]This word is first recorded in the period 1810–20. Other words that entered Englishat around the same time include: dominance, duplex, dynamic, keyboard, zombie-in is a noun suffix used in a special manner in chemical and mineralogical nomenclature(glycerin; acetin, etc.). In spelling, usage wavers between -in and -ine. In chemistry a certain distinction of use is attempted, basic substances havingthe termination -ine rather than -in (aconitine; aniline, etc.), and -in being restricted to certain neutral compounds, glycerides, glucosides, and proteids(albumin; palmitin, etc.), but this distinction is not always observed
Examples of 'hematin' in a sentence
hematin
Light and scanning electron microscopic observations further confirm accumulation of β-hematin with cellular toxicity.
Rohitas Deshmukh, Vishal Trivedi 2014, 'Phagocytic uptake of oxidized heme polymer is highly cytotoxic to macrophages.', PLoS ONEhttp://europepmc.org/articles/PMC4117526?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These findings suggest accumulation of hematin in infected livers.
Brice Masi, Teodora-Adriana Perles-Barbacaru, Caroline Laprie, Helia Dessein, MoniqueBernard, Alain Dessein, Angèle Viola 2015, 'In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosomiasis[corrected].', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC4578925?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this study, the role of exogenous hematin on anthocyanin biosynthesis was investigated.
Yi Li, Huayin Li, Fengde Wang, Jingjuan Li, Yihui Zhang, Liangju Wang, Jianwei Gao 2016, 'Comparative Transcriptome Analysis Reveals Effects of Exogenous Hematin on AnthocyaninBiosynthesis during Strawberry Fruit Ripening', International Journal of Genomicshttp://dx.doi.org/10.1155/2016/6762731. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This effort revealed that 171 of the β-hematin inhibitors are also active against the parasite.
Rebecca D. Sandlin, Kim Y. Fong, Kathryn J. Wicht, Holly M. Carrell, Timothy J. Egan,David W. Wright 2014, 'Identification of β-hematin inhibitors in a high-throughput screening effort revealsscaffolds with in vitro antimalarial activity', International Journal for Parasitology: Drugs and Drug Resistancehttp://www.sciencedirect.com/science/article/pii/S2211320714000220. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These regulatory networks may play an important role in regulating the color process of strawberries treated with hematin.
Yi Li, Huayin Li, Fengde Wang, Jingjuan Li, Yihui Zhang, Liangju Wang, Jianwei Gao 2016, 'Comparative Transcriptome Analysis Reveals Effects of Exogenous Hematin on AnthocyaninBiosynthesis during Strawberry Fruit Ripening', International Journal of Genomicshttp://dx.doi.org/10.1155/2016/6762731. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In endoscopic gastroscopy, two cases of the reinitiation of haemorrhages in the form of hematin on ulcers were fixed.
Evgeniy F. Cherednikov, Sergey V. Barannikov, Yuri V. Maleev, Konstantin O. Fursov,Tatyana E. Litovkina, Evgeniy I. Zakurdaev, Evgeniy S. Ovsyannikov 2017, 'Experimental Justification of Using Aseptisorb-A and Platelet-Rich Plasma in EndoscopicTreatment of Mold Bleeding Stomach Defects', International Journal of Biomedicinehttp://ijbm.org/articles/IJBM_7(4)_OA5.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Investigations on the dual antiparasitic mechanisms showed the correlation between inhibitory activity of β-hematin formation and antiparasitic activity.
Weisi Wang, Qiang Li, Yufen Wei, Jian Xue, Xiao Sun, Yang Yu, Zhuo Chen, Shizhu Li,Liping Duan 2017, 'Novel carbazole aminoalcohols as inhibitors of β-hematin formation: Antiplasmodialand antischistosomal activities', International Journal for Parasitology: Drugs and Drug Resistancehttp://www.sciencedirect.com/science/article/pii/S2211320716300914. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our results showed that β-hematin formation was induced by phospholipids in the fluid phase but not in the gel phase.
Nguyen Tien Huy, Yusuke Shima, Atsushi Maeda, Tran Thanh Men, Kenji Hirayama, Ai Hirase,Atsuo Miyazawa, Kaeko Kamei 2013, 'Phospholipid membrane-mediated hemozoin formation: the effects of physical propertiesand evidence of membrane surrounding hemozoin.', PLoS ONEhttp://europepmc.org/articles/PMC3720957?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)