a compound, C10H24N2, used in the treatment of severe hypertension to lower blood pressure and increase blood flow by blocking transmission of nerve impulses that constrict blood vessels
Word origin
[1945–50; hexa- + meth(yl) + (amm)onium]This word is first recorded in the period 1945–50. Other words that entered Englishat around the same time include: individual medley, poison pill, spin-off, synchronized swimming, taxi squadhexa- is a combining form meaning “six,” used in the formation of compound words. Otherwords that use the affix hexa- include: hexabasic, hexachlorophene, hexaemeron, hexahydrate, hexameter
Examples of 'hexamethonium' in a sentence
hexamethonium
Pretreatment with the nicotinic receptor antagonist, hexamethonium, blocked the effects of nicotine.
Steven R. Vigna 2016, 'Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis inRats', International Journal of Inflammationhttp://dx.doi.org/10.1155/2016/4705065. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hexamethonium administration reduced only kidney blood flow (50%).
K. De Angelis, V.M. Gama, V.A.M. Farah, M.C. Irigoyen 2005, 'Blood flow measurements in rats using four color microspheres during blockade of differentvasopressor systems', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100018. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The intensity of corneal nociception was not changed when atropine and hexamethonium were used alone.
Esmaeal Tamaddonfard, Amir-Abbas Farshid, Sona Seiednejhad, Asghar Morvaridi 2011, 'Role of the thalamic parafascicular nucleus cholinergic system in the modulation ofacute corneal nociception in rats', Veterinary Research Forumhttp://www.urmia.ac.ir/vrf/Shared%20Documents/pdf/vol-2%20no-4/226%20-%20230.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The responses after hexamethonium were more prominent in the hypertensive anesthetized group.
V.C. Biancardi, C.T. Bergamaschi, O.U. Lopes, R.R. Campos 2007, 'Sympathetic activation in rats with L-NAME-induced hypertension', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300016. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Atropine (0.5 mg/kg), hexamethonium (10 mg/kg) and propranolol (2 mg/kg) were ineffective on both circuits.
Graça J.R.V., Gondim F. de-A.A., Cavalcante D.I.M., Xavier-Neto J., Messias E.L.M.,Rego M.C.V., Marques J.A.P., Santos A.A., Rola F.H. 1997, 'Gastroduodenal resistance and neural mechanisms involved in saline flow decrease elicitedby acute blood volume expansion in anesthetized rats', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000019. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both effects were abolished by treatment with hexamethonium or pentolinium at doses sufficient to block nicotinic receptors.
Jen-Hao Hsu, Yang-Chang Wu, Shorong-Shii Liou, I-Min Liu, Lee-Wen Huang, Juei-TangCheng 2004, 'Mediation of Endogenous β-Endorphin by Tetrandrine to Lower Plasma Glucose in Streptozotocin-InducedDiabetic Rats', Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1093/ecam/neh027. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The tachycardia was eliminated by reserpine, nadolol or right vagal nerve stimulation, but not adrenalectomy, scopolamine or hexamethonium.
Torill eBerg, Jørgen eJensen 2011, 'Simultaneous parasympathetic and sympathetic activation reveals altered autonomiccontrol of heart rate, vascular tension and epinephrine release in anaesthetized hypertensiverats', Frontiers in Neurologyhttp://journal.frontiersin.org/Journal/10.3389/fneur.2011.00071/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)