the effect on the phenotype of interacting genes when their relative positions on the chromosome are altered, as by inversion
position effect in American English
noun
Genetics
the alteration in the expression of a gene or genetic region due to its relocation within the genome as a result of inversion or translocation
Word origin
[1925–30]This word is first recorded in the period 1925–30. Other words that entered Englishat around the same time include: Nazi, buildup, chain reaction, dropout, reflex camera
Examples of 'position effect' in a sentence
position effect
Importantly, the position effect depends on the condensin subunit, cut3+.
Haijin He, Shu Zhang, Danni Wang, Andreas Hochwagen, Fei Li 2016, 'Condensin Promotes Position Effects within Tandem DNA Repeats via the RITS Complex',Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124716000267. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They also identify two nucleolar factors controlling this position effect.
Danni Wang, Andres Mansisidor, Gayathri Prabhakar, Andreas Hochwagen 2016, 'Condensin and Hmo1 Mediate a Starvation-Induced Transcriptional Position Effect withinthe Ribosomal DNA Array', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124716000097. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The serial position effect was significant in all six blocks.
Fifić Mario 2002, 'Dynamics of serial position change in probe-recognition task', Psihologijahttp://www.doiserbia.nb.rs/img/doi/0048-5705/2002/0048-57050203261F.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This may be the result of the integration position effect.
Che-Yu Chu, Chi-Fang Chen, R Samuel Rajendran, Chia-Ning Shen, Te-Hao Chen, Chueh-ChuanYen, Chih-Kuang Chuang, Dar-Shong Lin, Chung-Der Hsiao 2012, 'Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.',PLoS ONEhttp://europepmc.org/articles/PMC3356305?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Position-effect variegation was used to stochastically perturb gene expression andprobe nuclear reorganization.
Brian Harmon, John Sedat 2005, 'Cell-by-cell dissection of gene expression and chromosomal interactions reveals consequencesof nuclear reorganization.', PLoS Biologyhttp://europepmc.org/articles/PMC1054879?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This position effect was observed with all six heterologous genes examined and with both transcriptional control elements.
Hollister Jason R, Harrison Robert L, Shi Xianzong, Mohammed Ahmed, Fraser MalcolmJ, Jarvis Donald L 2007, 'Construction and characterization of new piggyBac vectors for constitutiveor inducible expression of heterologous gene pairs and the identification of a previouslyunrecognized activator sequence in piggyBac', BMC Biotechnologyhttp://www.biomedcentral.com/1472-6750/7/5. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)