The biological effects of histamine are mediated through four histaminergic receptors.
Geffner J, Salamone G, Jancic C, Langellotti C, Alvarez CA, Amaral MM, Vermeulen M 2011, 'Thioperamide induces CD4+ CD25+ Foxp3+ regulatory T lymphocytes in the lung mucosaof allergic mice through its action on dendritic cells', Journal of Asthma and Allergyhttp://www.dovepress.com/thioperamide-induces-cd4-cd25-foxp3-regulatory-t-lymphocytes-in-the-lu-a8356. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These results suggest that the histaminergic system enhances learning and modulates stress responses in zebrafish.
L.P.V. Cofiel, R. Mattioli 2009, 'L-histidine enhances learning in stressed zebrafish', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100018. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Specifically, muscarinic and histaminergic pathways seem to play important roles.
Ana Maria Volpato, Alexandra Ioppi Zugno, João Quevedo 2013, 'Recent evidence and potential mechanisms underlying weight gain and insulin resistancedue to atypical antipsychotics', Revista Brasileira de Psiquiatriahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000300295&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Such effects seem to be mediated through the histaminergic system.
Hyejin Yang, Minseok Yoon, Min Young Um, Jaekwang Lee, Jonghoon Jung, Changho Lee,Yun-Tai Kim, Sangoh Kwon, Boknam Kim, Suengmok Cho 2017, 'Sleep-Promoting Effects and Possible Mechanisms of Action Associated with a StandardizedRice Bran Supplement', Nutrientshttp://www.mdpi.com/2072-6643/9/5/512. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The antisecretory effect may involve a mechanism common to both cholinergic and histaminergic pathways.
Amang André Perfusion, Paul V. Tan, Nkwengoua Ernestine, Nyasse Barthélemy 2014, 'Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae)Occurs through Antihistaminic and Anticholinergic Pathways', Advances in Pharmacological Scienceshttp://dx.doi.org/10.1155/2014/323470. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The histaminergic system exists downstream of leptin, a satiety factor secreted from white adipose tissue.
Tomoko eIshizuka, Atsushi eYamatodani 2012, 'Integrative role of the histaminergic system in feeding and taste perception', Frontiers in Systems Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00044/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in thepresence of histaminergic agonists.
Nora Goren, Claudia Perez Leiros, Leonor Sterin-Borda, Enri S. Borda 1993, 'Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice',Mediators of Inflammationhttp://dx.doi.org/10.1155/S0962935193000444. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thirty studies reported a hypothesized mechanism of action, most commonly activation/inhibition of cholinergic, histaminergic and dopaminergic receptors.
Janet Sultana, Marco Calabró, Ricard Garcia-Serna, Carmen Ferrajolo, Concetta Crisafulli,Jordi Mestres, Gianluca Trifirò' 2017, 'Biological substantiation of antipsychotic-associated pneumonia: Systematic literaturereview and computational analyses.', PLoS ONEhttp://europepmc.org/articles/PMC5659779?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This indicates that muscarinic or histaminergic mechanisms are not likely to be involved in the hypotension produced by the extract.
Lodagala Durga S, Babu Behara S Ravindra, Gudavalli Rambabu, Nammi Srinivas, BoiniKrishna M 2003, 'Possible mechanisms of hypotension produced 70% alcoholic extract of Terminaliaarjuna (L.) in anaesthetized dogs', BMC Complementary and Alternative Medicinehttp://www.biomedcentral.com/1472-6882/3/5. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Under the action of nanomaterial on isolated segments, amplitudes of cholinergic and histaminergic contractile reactions increased.
T. N. Zaitseva, A. V. Nosarev, Ye. Yu. Diyakova, L. V. Kapilevich, B. G. Ageyev, L.N. Ogorodova, A. A. Magayeva, O. G. Terekhova, V. I. Iteen 2010, 'Role of cytoskeleton in formation of airway muscle activity in the presence of nanosizedmagnetite', Bûlleten' Sibirskoj Medicinyhttps://bulletin.tomsk.ru/jour/article/view/1698. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)