Magnocellular neurones represent targets for the anorexigenic neuropeptide α-melanocyte stimulating hormone.
Nancy eSabatier, Gareth eLeng, John eMenzies 2013, 'Oxytocin, feeding and satiety', Frontiers in Endocrinologyhttp://journal.frontiersin.org/Journal/10.3389/fendo.2013.00035/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We viewed the anorexigenic effect as an additional advantage for promoting initial weight loss.
Alison Sally Poulton, Emily Jane Hibbert, Bernard Linton Champion, Traci eCook, DavideAlais, David eCoulshed 2015, 'Piloting a new approach to the treatment of obesity using dexamphetamine', Frontiers in Endocrinologyhttp://journal.frontiersin.org/Journal/10.3389/fendo.2015.00014/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hypothalamic gene expression measurements revealed increased expression of orexigenic and decreased expression of anorexigenic signals.
Amanda C. Morris, Lynda M. Williams, Klaus W. Wahle, Jung-Heun Ha, Shabina Bashir,Sharon E. Mitchell, Alan A. Sneddon, D. Vernon Rayner 2009, 'Dietary Supplementation with Conjugated Linoleic Acid Plus n-3 Polyunsaturated FattyAcid Increases Food Intake and Brown Adipose Tissue in Rats', Nutrientshttp://www.mdpi.com/2072-6643/1/2/178/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The orexigenic and anorexigenic phenotype of these neurons was identified by functional response to ghrelin and leptin hormones, respectively.
Lígia Sousa-Ferreira, Ana Rita Álvaro, Célia Aveleira, Magda Santana, Inês Brandão,Sebastian Kügler, Luís Pereira de Almeida, Cláudia Cavadas 2011, 'Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-Aand differentiate to functional neurons.', PLoS ONEhttp://europepmc.org/articles/PMC3092771?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
At present, the adipocyte-derived hormone leptin and the pancreatic β-cell derivedhormone insulin are considered the principal anorexigenic hormones.
Mina Thon, Toru Hosoi, Koichiro Ozawa 2016, 'Possible integrative actions of leptin and insulin signaling in the hypothalamus targetingenergy homeostasis', Frontiers in Endocrinologyhttp://journal.frontiersin.org/Journal/10.3389/fendo.2016.00138/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our results show that both orexigenic and anorexigenic factors are present in the telencephalon, diencephalon and mesencephalon in cod larvae.
Hoang T. M. D. Le, Anna Rita Angotzi, Lars O. E. Ebbesson, Ørjan Karlsen, Ivar Rønnestad 2016, 'The Ontogeny and Brain Distribution Dynamics of the Appetite Regulators NPY, CARTand pOX in Larval Atlantic Cod (Gadus morhua L.)', PLOS ONE10.1371/journal.pone.0153743. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Obestatin, a proposed anorexigenic gut hormone, has been shown to have a number of beneficial cardiotropic effects in experimental studies.
Ilia Beberashvili, Inna Sinuani, Ada Azar, Hadas Kadoshi, Gregory Shapiro, LeonidFeldman, Judith Sandbank, Zhan Averbukh 2013, 'Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance HemodialysisPatients', BioMed Research Internationalhttp://dx.doi.org/10.1155/2013/796586. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The anorexigenic peptides (pomc and cartpt) did not show any significant modulation between the groups, similar to mboat4.
Rafael Opazo, Francisca Plaza-Parrochia, Gustavo R. Cardoso dos Santos, Gabriel R.A. Carneiro, Vinicius F. Sardela, Jaime Romero, Luis Valladares 2019, 'Fasting Upregulates npy, agrp, and ghsr Without Increasing Ghrelin Levels in Zebrafish(Danio rerio) Larvae', Frontiers in Physiologyhttps://www.frontiersin.org/article/10.3389/fphys.2018.01901/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hypothalamic malprogramming towards decreased anorexigenic activity was involved intothe pathophysiology of this neonatally acquired adverse phenotype.
Karen Schellong, Uta Neumann, Rebecca C Rancourt, Andreas Plagemann 2013, 'Increase of long-term 'diabesity' risk, hyperphagia, and altered hypothalamic neuropeptideexpression in neonatally overnourished 'small-for-gestational-age' (SGA) rats.', PLoS ONEhttp://europepmc.org/articles/PMC3827123?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)