As a neurosteroid, pregnenolone sulfate modulates a variety of ion channels, transporters, and enzymes.
Christian Harteneck 2013, 'Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand', Moleculeshttp://www.mdpi.com/1420-3049/18/10/12012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Abiraterone acetate was developed by rational design based on a pregnenolone parent structure.
Michael T. Schweizer, Emmanuel S. Antonarakis 2012, 'Abiraterone and other novel androgen-directed strategies for the treatment of prostatecancer: a new era of hormonal therapies is born', Therapeutic Advances in Urologyhttps://doi.org/10.1177/1756287212452196. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
16α,17α-epoxy-pregnenolone underwent a rare epoxide opening with retention stereochemistry to give four 16α-hydroxy-lactones.
Alina Świzdor, Anna Panek, Paulina Ostrowska 2018, 'Metabolic fate of pregnene-based steroids in the lactonization pathway of multifunctionalstrain Penicillium lanosocoeruleum', Microbial Cell Factorieshttp://link.springer.com/article/10.1186/s12934-018-0948-1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A series of epoxy- and/or 20-oxime pregnanes were synthesized from commercially available pregnenolone.
Sujeong Kim, Eunsook Ma 2009, 'Synthesis of Pregnane Derivatives, Their Cytotoxicity on LNCap and PC-3 Cells, andScreening on 5α-Reductase Inhibitory Activity', Moleculeshttp://www.mdpi.com/1420-3049/14/11/4655/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pregnenolone steroids were more abundant in cases and carnitine metabolites were more abundant in controls.
Rachel S Kelly, Jessica Lasky-Su, Sai-Ching J Yeung, Richard M Stone, Jeffrey M Caterino,Sean C Hagan, Gary H Lyman, Lindsey R Baden, Brett E Glotzbecker, Christopher J Coyne,Christopher W Baugh, Daniel J Pallin 2018, 'Integrative omics to detect bacteremia in patients with febrile neutropenia.', PLoS ONEhttp://europepmc.org/articles/PMC5955575?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
After 24 hours of culture, cells were washed and the precursor pregnenolone was added.
Mariana N. La Paz, Vanessa U. Fonseca, Danila B. Campos, Laura P. Artoni, Liza M.M. C. Sousa, Paula C. Papa 2007, 'Produção de progesterona in vitro pelas células do corpo lúteo bovino ao longo dagestação In vitro progesterone production from bovine corpus luteum throughout gestation',Pesquisa Veterinária Brasileirahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2007000900003. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We propose pregnenolone as a “lymphosteroid,” a steroid produced by lymphocytes.
Bidesh Mahata, Xiuwei Zhang, Aleksandra A. Kolodziejczyk, Valentina Proserpio, LioraHaim-Vilmovsky, Angela E. Taylor, Daniel Hebenstreit, Felix A. Dingler, Victoria Moignard,Berthold Göttgens, Wiebke Arlt, Andrew N.J. McKenzie, Sarah A. Teichmann 2014, 'Single-Cell RNA Sequencing Reveals T Helper Cells Synthesizing Steroids De Novo toContribute to Immune Homeostasis', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124714002988. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The pregnenolone level also dropped in the differentiated ovary.
Dongdong Liang, Zhaofei Fan, Yuxia Zou, Xungang Tan, Zhihao Wu, Shuang Jiao, Jun Li,Peijun Zhang, Feng You 2018, 'Characteristics of Cyp11a during Gonad Differentiation of the Olive Flounder Paralichthysolivaceus', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/19/9/2641. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most recently, pregnenolone sulfate has been functionally “upgraded” from modulatorof ion channels to an activating ion channel ligand.
Christian Harteneck 2013, 'Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand', Moleculeshttp://www.mdpi.com/1420-3049/18/10/12012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)