A team searched the genome of the zebrafish for Hox genes, which control developmentof the head-to-tail axis of the body.
Examples of 'hox' in a sentence
hox
Hox genes were critical to many morphological innovations of bilaterian animals.
Joseph F Ryan, Maureen E Mazza, Kevin Pang, David Q Matus, Andreas D Baxevanis, MarkQ Martindale, John R Finnerty 2007, 'Pre-bilaterian origins of the Hox cluster and the Hox code: evidence from the seaanemone, Nematostella vectensis.', PLoS ONEhttp://europepmc.org/articles/PMC1779807?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hox genes are arranged in clusters with up to 14 genes.
Roth Jutta J, Lynch Vincent J, Wagner Günter P 2006, 'Adaptive evolution of Hox-gene homeodomains after cluster duplications', BMC Evolutionary Biologyhttp://www.biomedcentral.com/1471-2148/6/86. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hox homeodomain transcription factors are key regulators of animal development.
Daria Shlyueva, Antonio C A Meireles-Filho, Michaela Pagani, Alexander Stark 2016, 'Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci atDevelopmental Regulators and a Potential Connection to Polycomb-Mediated Regulation.',PLoS ONEhttp://europepmc.org/articles/PMC5004984?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hox transcription factors provide positional information during patterning of the anteroposterior axis.
Paul M J In der Rieden, Hans J Jansen, Antony J Durston 2011, 'XMeis3 is necessary for mesodermal Hox gene expression and function.', PLoS ONEhttp://europepmc.org/articles/PMC3065463?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hox genes are determinants of rhombomere-derived fate and neuronal connectivity.
Maria Di Bonito, Yuichi Narita, Bice Avallone, Luigi Sequino, Marta Mancuso, GennaroAndolfi, Anna Maria Franzè, Luis Puelles, Filippo M Rijli, Michèle Studer 2013, 'Assembly of the auditory circuitry by a Hox genetic network in the mouse brainstem.',PLoS Geneticshttp://europepmc.org/articles/PMC3567144?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hox proteins are conserved homeodomain transcription factors known to be crucial regulators of animal development.
Isabelle Bergiers, Laure Bridoux, Nathan Nguyen, Jean-Claude Twizere, René Rezsöhazy 2013, 'The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomaldegradation of the E3 ubiquitin protein ligase RCHY1.', PLoS ONEhttp://europepmc.org/articles/PMC3820564?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hox genes are also expressed in various adult tissues and cancer cells.
Yasushi Taniguchi 2014, 'Hox Transcription Factors: Modulators of Cell-Cell and Cell-Extracellular Matrix Adhesion',BioMed Research Internationalhttp://dx.doi.org/10.1155/2014/591374. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
At stages immediately after fertilization, nucleosomes appear to be largely disordered at hox promoter regions.
Steven E Weicksel, Jia Xu, Charles G Sagerström 2013, 'Dynamic nucleosome organization at hox promoters during zebrafish embryogenesis.',PLoS ONEhttp://europepmc.org/articles/PMC3650070?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hox genes play important roles in haematopoietic development in mammals.
Yujiro Tanaka, Koji Kawahashi, Zen-Ichiro Katagiri, Yasuhiro Nakayama, Milind Mahajan,Dimitris Kioussis 2011, 'Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hoxgene expression.', PLoS ONEhttp://europepmc.org/articles/PMC3225378?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)