The study population was divided into 3 age groups: prepubertal, adolescent, and juvenile.
Lubov I. Kolesnikova, Marina A. Darenskaya, Natalia V. Semenova, Lyudmila A. Grebenkina,Larisa V. Suturina, Marya I. Dolgikh, Svetlana V. Gnusina 2015, 'Lipid peroxidation and antioxidant protection in girls with type 1 diabetes mellitusduring reproductive system development', Medicinahttp://www.sciencedirect.com/science/article/pii/S1010660X15000257. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We assessed the clinical course of prepubertal patients to propose appropriate management.
Jang Hee Han, Yong Seung Lee, Young Jae Im, Sang Woon Kim, Mi-Jung Lee, Sang Won Han 2016, 'Clinical Implications of Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA)Syndrome in the Prepubertal Age Group.', PLoS ONEhttp://europepmc.org/articles/PMC5115795?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, stressed prepubertal and adult animals evaluated immediately had reduced glomerular volumetric density.
Roger Gaspar Marchon, Carina Teixeira Ribeiro, Waldemar Silva Costa, Francisco José BarcellosSampaio, Marco Aurélio Pereira-Sampaio, Diogo Benchimol de Souza 2018, 'Immediate and Late Effects of Stress on Kidneys of Prepubertal and Adult Rats', Kidney & Blood Pressure Researchhttps://www.karger.com/Article/FullText/496004. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We analyzed the behavioral test at a prepubertal age.
Marisol Pineda-Reynoso, Edgar Cano-Europa, Vanessa Blas-Valdivia, et al 2010, 'Hypothyroidism during neonatal and perinatal period induced by thyroidectomy of themother causes depressive-like behavior in prepubertal rats', Neuropsychiatric Disease and Treatmenthttp://www.dovepress.com/hypothyroidism-during-neonatal-and-perinatal-period-induced-by-thyroid-a4274. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the decrease in the body weight at prepubertal age was compensated during adult life.
Sabrina Amalfi, Leandro Martín Velez, María Florencia Heber, Susana Vighi, SilvanaRocío Ferreira, Adriana Vega Orozco, Omar Pignataro, Alicia Beatriz Motta 2012, 'Prenatal Hyperandrogenization Induces Metabolic and Endocrine Alterations Which Dependon the Levels of Testosterone Exposure', PLoS ONE10.1371/journal.pone.0037658. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pelvic ultrasonography showed prepubertal reproduction organs in 26/35.
Jose R. L. Batubara, Adji Suranto, Sudigdo Sastroasmoro, Bambang Tridjaja, Aman B.Pulungan 2001, 'Natural history of premature thelarche: review of 60 girls', Paediatrica Indonesianahttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1042. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The greatest coefficient of oxidative stress (1.16) was observed in the prepubertal period.
Lubov I. Kolesnikova, Marina A. Darenskaya, Natalia V. Semenova, Lyudmila A. Grebenkina,Larisa V. Suturina, Marya I. Dolgikh, Svetlana V. Gnusina 2015, 'Lipid peroxidation and antioxidant protection in girls with type 1 diabetes mellitusduring reproductive system development', Medicinahttp://www.sciencedirect.com/science/article/pii/S1010660X15000257. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
More pronounced changes were observed in prepubertal patients.
N.A. Sprinchuk 2019, 'Assessment of somatotropic function in children with syndrome of biologically inactivegrowth hormone against a background of clonidine and insulin stimulation tests', Mìžnarodnij Endokrinologìčnij Žurnalhttp://iej.zaslavsky.com.ua/article/view/166108. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Leptin receptor expression significantly increased in the prepubertal male, adult male, and adultfemale pups.
Ayfer Dayi, Sinem Agilkaya, Seda Ozbal, Ferihan Cetin, Ilkay Aksu, Celal Gencoglu,Sultan Cingoz, Cetın Pekcetin, Kazim Tugyan, Berkant Muammer Kayatekin, Nazan Uysal 2012, 'Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by AffectingLeptin Expression on Offspring's Early and Late Period in Life Depending on Gender',The Scientific World Journalhttp://dx.doi.org/10.1100/2012/429803. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)