a muscle-relaxant drug used to treat high blood pressure by dilating blood vessels
Trade name: Apresoline
hydralazine in American English
(haiˈdræləˌzin)
noun
Pharmacology
a white crystalline powder, C8H8N4, that dilates blood vessels and is used in the treatment of hypertension
Word origin
[1950–55; hydr-2 + (phth)al(ic) + azine]This word is first recorded in the period 1950–55. Other words that entered Englishat around the same time include: allograph, conflict of interest, point spread, point-of-sale, speech recognition
Examples of 'hydralazine' in a sentence
hydralazine
With regard to the most prescribed medications, hydralazine was the most utilized in the service.
Thereza Maria Magalhães Moreira, Ione Cavalcante Lacerda 2011, 'Características obstétricas de mulheres atendidas por pré-eclâmpsia e eclâmpsia- doi: 10.4025/actascihealthsci.v33i1.7711 Obstetric characteristics of women treatedfor pre-eclampsia and eclampsia - doi: 10.4025/actascihealthsci.v33i1.7711', Acta Scientiarum: Health Scienceshttp://www.periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/7711. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Losartan prevented these effects completely, whereas hydralazine was unable to affect these changes.
Bart F. J. Heijnen, Jelly Nelissen, Helma van Essen, Gregorio E. Fazzi, Jan W. CohenTervaert, Carine J. Peutz-Kootstra, John J. Mullins, Casper G. Schalkwijk, Ben J.A. Janssen, Harry AJ. Struijker-Boudier 2013, 'Irreversible Renal Damage after Transient Renin-Angiotensin System Stimulation: Involvementof an AT1-Receptor Mediated Immune Response', PLoS ONE10.1371/journal.pone.0057815. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The aldosterone infusion groups were treated with hydralazine to correct blood pressure differences.
Yuji Sogawa, Hajime Nagasu, Seiji Itano, Kengo Kidokoro, Shun'ichiro Taniguchi, MasafumiTakahashi, Hiroyuki Kadoya, Minoru Satoh, Tamaki Sasaki, Naoki Kashihara 2018, 'The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasomeactivation in aldosterone-induced renal injury model mice', PLOS ONE10.1371/journal.pone.0203823. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Interestingly, losartan, but not hydralazine treatment, markedly reduced sphingomyelinase-induced contractions.
Léon J A Spijkers, Ben J A Janssen, Jelly Nelissen, Merlijn J P M T Meens, DayanjanWijesinghe, Charles E Chalfant, Jo G R De Mey, Astrid E Alewijnse, Stephan L M Peters 2011, 'Antihypertensive treatment differentially affects vascular sphingolipid biology inspontaneously hypertensive rats.', PLoS ONEhttp://europepmc.org/articles/PMC3240660?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hydralazine has been used since the 1950s for the management of hypertension.
Faizan Babar, Jeffery N. Posner, Eugene A. Obah 2016, 'Hydralazine-induced pauci-immune glomerulonephritis: intriguing case series with misleadingdiagnoses', Journal of Community Hospital Internal Medicine Perspectiveshttp://www.jchimp.net/index.php/jchimp/article/view/30632/pdf_135. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
She was treated with intravenous steroids and subsequently with immunosuppression after cessation of hydralazine.
Rajaie Namas, Bernard Rubin, Wamidh Adwar, Alireza Meysami 2014, 'A Challenging Twist in Pulmonary Renal Syndrome', Case Reports in Rheumatologyhttp://dx.doi.org/10.1155/2014/516362. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hydralazine was discontinued and the patient was treated with corticosteroids and intravenous cyclophosphamide.
Gaurav Agarwal, Ghayyath Sultan, Sherry L. Werner, Claudia Hura 2014, 'Hydralazine Induces Myeloperoxidase and Proteinase 3 Anti-Neutrophil Cytoplasmic AntibodyVasculitis and Leads to Pulmonary Renal Syndrome', Case Reports in Nephrologyhttp://dx.doi.org/10.1155/2014/868590. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Renal biopsy revealed classic crescentic (pauci-immune) glomerulonephritis in these patients and hydralazine wasdiscontinued.
Roman Zuckerman, Mayurkumar Patel, Eric J Costanzo, Harry Dounis, Rany Al Haj, SeyedehsaraSeyedali, Arif Asif 2018, 'Hydralazine-associated adverse events: a report of two cases of hydralazine-inducedANCA vasculitis', Brazilian Journal of Nephrologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002018005008103&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Management included cessation of hydralazine and a prolonged steroid taper.
Sarah K. Holman, Donique Parris, Sarah Meyers, Jason Ramirez 2017, 'Acute Low-Dose Hydralazine-Induced Lupus Pneumonitis', Case Reports in Pulmonologyhttp://dx.doi.org/10.1155/2017/2650142. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)