the introduction of hydroxyl into a chemical compound
Examples of 'hydroxylation' in a sentence
hydroxylation
Importantly, this system accurately preserves the specificity of the hydroxylation reaction toward specific substrates.
Alcaide-German Maria L, Vara-Vega Alicia, Garcia-Fernandez Luis F, Landazuri ManuelO, del Peso Luis 2008, 'A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factorregulatory machinery', BMC Cell Biologyhttp://www.biomedcentral.com/1471-2121/9/18. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Toxicity can be related to aromatic hydroxylation.
Rosivaldo S. Borges, Ivanete C. Palheta, Sirlene S. B. Ota, Roberto B. Morais,Valéria A. Barros, Ryan S. Ramos, Rai C. Silva, Josivan da S. Costa, Carlos H.T. P. Silva, Joaquín M. Campos, Cleydson B. R. Santos 2019, 'Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism',Moleculeshttp://www.mdpi.com/1420-3049/24/1/143. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, there were limited reports about its hydroxylation activity towards steroids.
Xing Liu, Jian-qiang Kong 2017, 'Steroids hydroxylation catalyzed by the monooxygenase mutant 139-3 from Bacillus megateriumBM3', Acta Pharmaceutica Sinica Bhttp://www.sciencedirect.com/science/article/pii/S2211383517300667. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Polyols synthesis involved two steps, namely, hydroxylation and alcoholysis reaction.
Paweena Ekkaphan, Sarintip Sooksai, Nuanphun Chantarasiri, Amorn Petsom 2016, 'Bio-Based Polyols from Seed Oils for Water-Blown Rigid Polyurethane Foam Preparation',International Journal of Polymer Sciencehttp://dx.doi.org/10.1155/2016/4909857. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These analogs have anti-inflammatory activities that are influenced by side chain composition and by 1α-hydroxylation.
Zongtao Lin, Srinivasa R. Marepally, Emily S. Y. Goh, Chloe Y. S. Cheng, Zorica Janjetovic,Tae-Kang Kim, Duane D. Miller, Arnold E. Postlethwaite, Andrzej T. Slominski, RobertC. Tuckey, Carole Peluso-Iltis, Natacha Rochel, Wei Li 2018, 'Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potentvitamin D receptor agonists with anti-inflammatory activities', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-19183-7. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Previous studies demonstrated the hydroxylation and glucuronidation of loxoprofen.
Riya Shrestha, Pil Joung Cho, Sanjita Paudel, Aarajana Shrestha, Mi Jeong Kang,Tae Cheon Jeong, Eung-Seok Lee, Sangkyu Lee 2018, 'Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of CytochromeP450 and UDP-Glucuronosyltransferase in Its Biotransformation', Pharmaceuticshttp://www.mdpi.com/1999-4923/10/3/112. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thus, ribosome hydroxylation may be a well-conserved regulatory mechanism with implications in disease and development.
Katharina E. Bräuer, Kevin Brockers, Jasmin Moneer, Annette Feuchtinger, Evi Wollscheid-Lengeling,Andreas Lengeling, Alexander Wolf 2018, 'Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2(Mina53) provide new insights into their evolution', BMC Evolutionary Biologyhttp://link.springer.com/article/10.1186/s12862-018-1215-0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
As a result of regio- and enantioselective hydroxylation four new oxygenated derivatives were obtained.
Marcelina Mazur, Witold Gładkowski, Višnja Gaurina Srček, Kristina Radošević, GabrielaMaciejewska, Czesław Wawrzeńczyk 2017, 'Regio- and enantioselective microbial hydroxylation and evaluation of cytotoxic activityof β-cyclocitral-derived halolactones', PLOS ONE10.1371/journal.pone.0183429. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)