Moreover, neuronal apoptosis was markedly increased, and 5-hydroxytryptamine levels were reduced.
Jian Liu, Yu-Hong Wang, Wei Li, Lin Liu, Hui Yang, Pan Meng, Yuan-Shan Han 2019, 'Structural and functional damage to the hippocampal neurovascular unit in diabetes-relateddepression', Neural Regeneration Researchhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=2;spage=289;epage=297;aulast=Liu. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Various 5-hydroxytryptamine-3 antagonists have shown to reduce propofol-induced pain.
Gangur Basappa Sumalatha, Ravichandra Ramesh Dodawad, Sandeep Pandarpurkar, ParashuramR Jajee 2016, 'A comparative study of attenuation of propofol-induced pain by lignocaine, ondansetron,and ramosetron', Indian Journal of Anaesthesiahttp://www.ijaweb.org/article.asp?issn=0019-5049;year=2016;volume=60;issue=1;spage=25;epage=29;aulast=Sumalatha. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These defensive reaction responses are critically mediated by γ-aminobutyric acid and 5-hydroxytryptamine mechanisms in the midbrain tectum.
J.C. Brenes, A.C. Broiz, G.S. Bassi, R.K.W. Schwarting, M.L. Brandão 2012, 'Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety',Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000400009&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
5-hydroxytryptamine receptor antagonist may be effective in preventing the pain/limb shrinkage reaction associated with rocuronium injection.
Qixiong He, Chengmao Zhou, Yu Zhu 2018, 'The Effect of 5-Hydroxytryptamine Receptor Antagonist in Preventing Pain/Limb ShrinkageReaction Associated with Rocuronium Injection', BioMed Research Internationalhttp://dx.doi.org/10.1155/2018/4128415. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The concentrations of hippocampal 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were measured usinghigh-performance liquid chromatography-electrochemical detection.
Yan-Ping Wu, Hua-Ying Gao, Shu-Hua Ouyang, Hiroshi Kurihara, Rong-Rong He, Yi-FangLi 2019, 'Predator stress-induced depression is associated with inhibition of hippocampal neurogenesisin adult male mice', Neural Regeneration Researchhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=2;spage=298;epage=305;aulast=Wu. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Inflammatory mediators include 5-hydroxytryptamine and cytokines, as well as reactive oxygen species and the production of oxidative stress.
Kirchgessner Annette, Lakhan Shaheen E 2010, 'Neuroinflammation in inflammatory bowel disease', Journal of Neuroinflammationhttp://www.jneuroinflammation.com/content/7/1/37. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In contrast, the dopamine level was decreased, and the 5-hydroxytryptamine level was not significantly affected.
Hailong Kong, Chuanlei Dong, Zhen Tian, Nian Mao, Cheng Wang, Yunxia Cheng, Lei Zhang,Xingfu Jiang, Lizhi Luo 2018, 'Altered immunity in crowded Mythimna separata is mediated by octopamine and dopamine',Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-20711-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Prokinetic therapies, such as the selective 5-hydroxytryptamine receptor 4 agonist revexepride, may aid gastric emptying.
Flach S, Croft M, Ding J, Budhram R, Pankratz T, Pennick M, Scarfe G, Troy S, GetsyJ 2016, 'Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase Iclinical trial using a microtracer and accelerator mass spectrometry-based approach',Drug Design, Development and Therapyhttps://www.dovepress.com/pharmacokinetics-absorption-and-excretion-of-radiolabeled-revexepride--peer-reviewed-article-DDDT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)