relating to or describing a symptom that occurs before the typical symptoms of a disease
Examples of 'presymptomatic' in a sentence
presymptomatic
Structural and functional imaging show typical early changes also in presymptomatic monogenic carriers.
Andrea Pilotto, Alessandro Padovani, Barbara Borroni 2013, 'Clinical, Biological, and Imaging Features of Monogenic Alzheimer's Disease', BioMed Research Internationalhttp://dx.doi.org/10.1155/2013/689591. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Kif1b was the unique deregulated gene in more than one studied region or presymptomatic age.
Jessica Ruivo Maximino, Gabriela Pintar de Oliveira, Chrystian Junqueira Alves, GersoneChadi 2014, 'Deregulated expression of cytoskeleton related genes in the spinal cord and sciaticnerve of presymptomatic SOD1G93A Amyotrophic Lateral Sclerosis mouse model', Frontiers in Cellular Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fncel.2014.00148/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Brain magnetic resonance imaging was normal at the presymptomatic phase but later showed olivary hypertrophy.
Jaana Korpela, Juho Joutsa, Juha O. Rinne, Jörgen Bergman, Valtteri Kaasinen 2015, 'Hypermetabolism of Olivary Nuclei in a Patient with Progressive Ataxia and PalatalTremor', Tremor and Other Hyperkinetic Movementshttps://tremorjournal.org/index.php/tremor/article/view/342. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We assess how presymptomatic infection affects predictability of infectious disease epidemics.
Robin N Thompson, Christopher A Gilligan, Nik J Cunniffe 2016, 'Detecting Presymptomatic Infection Is Necessary to Forecast Major Epidemics in theEarliest Stages of Infectious Disease Outbreaks.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC4821482?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The negative presymptomatic diagnostic result allowed the patient to choose normal delivery at term.
Naing BT, Watanabe A, Tanigaki S, Ono M, Iwashita M, Shimada T 2014, 'Presymptomatic genetic analysis during pregnancy for vascular type Ehlers–Danlossyndrome', International Medical Case Reports Journalhttp://www.dovepress.com/presymptomatic-genetic-analysis-during-pregnancy-for-vascular-type-ehl-a17272. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Often the recognition of such dermatological manifestations help in the presymptomatic diagnosis of complex syndromes.
S M Simi, Beena Narayanan, G Nandakumar 2012, 'Not just skin deep: A case report of multiple endocrine neoplasia type 1', Indian Journal of Dermatologyhttp://www.e-ijd.org/article.asp?issn=0019-5154;year=2012;volume=57;issue=4;spage=304;epage=307;aulast=Simi. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, it remains difficult, if not impossible, to evaluate social relationships in presymptomatic patients.
Elodie eDURAND, Odile ePETIT, Léon eTREMBLAY, Cédric eZIMMER, Véronique eSGAMBATO-FAURE,Carine eCHASSAIN, Marlène eLAURENT, Bruno ePEREIRA, Céline eSILBERBERG, Franck eDURIF 2015, 'SOCIAL BEHAVIORAL CHANGES IN MPTP-TREATED MONKEY MODEL OF PARKINSON'S DISEASE.', Frontiers in Behavioral Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00042/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Two patients – out of three who had received presymptomatic treatment – demonstrated stable voice quality compared with 2014.
Krzysztof Szklanny, Anna Tylki-Szymańska 2018, 'Follow-up analysis of voice quality in patients with late-onset Pompe disease', Orphanet Journal of Rare Diseaseshttp://link.springer.com/article/10.1186/s13023-018-0932-1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Behavioural results showed no differences in the ability to recognize emotions between presymptomatic gene carriers and controls.
Marieke evan Asselen, Filipa eJúlio, Cristina eJanuário, Elzbieta eBobrowicz Campos,Inês eAlmeida, Sara eCavaco, Miguel eCastelo-Branco 2012, 'Scanning patterns of faces do not explain impaired emotion recognition in HuntingtonDisease: Evidence for a high level mechanism', Frontiers in Psychologyhttp://journal.frontiersin.org/Journal/10.3389/fpsyg.2012.00031/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Longer natural history studies are needed to inform design of trials aimed at the presymptomatic stage.
Dominic Holland, Linda K McEvoy, Rahul S Desikan, Anders M Dale 2012, 'Enrichment and stratification for predementia Alzheimer disease clinical trials.',PLoS ONEhttp://europepmc.org/articles/PMC3474753?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)