The model also predicts that circadian control of certain ionic currents can induce hyperexcited states.
Casey O Diekman, Mino D C Belle, Robert P Irwin, Charles N Allen, Hugh D Piggins,Daniel B Forger 2013, 'Causes and consequences of hyperexcitation in central clock neurons.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC3749949?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The model predicts that hyperexcited states cause high intracellular calcium concentrations, which could trigger transcription of clock genes.
Casey O Diekman, Mino D C Belle, Robert P Irwin, Charles N Allen, Hugh D Piggins,Daniel B Forger 2013, 'Causes and consequences of hyperexcitation in central clock neurons.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC3749949?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)