Unfortunately, the mechanisms involved in hypermetabolism are essentially unknown.
David Patsouris, Peter Qi, Abdikarim Abdullahi, Mile Stanojcic, Peter Chen, AlexandraParousis, Saeid Amini-Nik, Marc G. Jeschke 2015, 'Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans',Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124715011985. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Correlations have been found between the presence of tics and hypermetabolism in variousbrain regions.
Debes NM, Préel M, Skov L 2017, 'Functional neuroimaging in Tourette syndrome: recent perspectives', Neuroscience and Neuroeconomicshttps://www.dovepress.com/functional-neuroimaging-in-tourette-syndrome-recent-perspectives-peer-reviewed-article-NAN. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The presence of hypermetabolism may be a factor related to poorer prognosis.
Cassiana R. de Góes, André Luis Balbi, Daniela Ponce 2018, 'Evaluation of Factors Associated with Hypermetabolism and Hypometabolism in CriticallyIll AKI Patients', Nutrientshttp://www.mdpi.com/2072-6643/10/4/505. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It was found the original hypermetabolism and its paradoxical decrease after induced stress.
P.P. Chernysh, F.A. Khaidarova, A.S. Fazyldzhanova, U.K. Kayumov, M.S. Akhmedova,A.A. Guleva 2013, 'Adaptive Capacity and Features of Energy Metabolism in Patients with Diabetes MellitusType 2', Mìžnarodnij Endokrinologìčnij Žurnalhttp://iej.zaslavsky.com.ua/article/view/84488. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
After 3 months, follow-up abdominal computed tomography revealed a subhepatic nodule, which showed hypermetabolism on positron emission tomography–computed tomography.
Hasong Jeong, Hye Won Lee, Hye ra Jung, Ilseon Hwang, Sun Young Kwon, Yu Na Kang,Sang Pyo Kim, Misun Choe 2018, 'Bile Granuloma Mimicking Peritoneal Seeding: A Case Report', Journal of Pathology and Translational Medicinehttp://www.jpatholtm.org/upload/pdf/jptm-2018-06-02.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The metabolic cerebral changes suggest immediate transient substrate failure followed by hypermetabolism of glucose upon reperfusion.
Christoffer Nyberg, Torbjörn Karlsson, Lars Hillered, Elisabeth Ronne Engström 2014, 'Metabolic pattern of the acute phase of subarachnoid hemorrhage in a novel porcinemodel: studies with cerebral microdialysis with high temporal resolution.', PLoS ONEhttp://europepmc.org/articles/PMC4062436?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We hypothesized that the adipose tissue plays a central role for the induction and persistence of hypermetabolism post-burn injury.
David Patsouris, Peter Qi, Abdikarim Abdullahi, Mile Stanojcic, Peter Chen, AlexandraParousis, Saeid Amini-Nik, Marc G. Jeschke 2015, 'Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans',Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124715011985. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Response to thermal injury includes cellular protection mechanisms, inflammation, hypermetabolism, prolonged catabolism, organ dysfunction and immuno-suppression.
Berthiaume Francois, Yarmush Martin L, Maguire Timothy, Yang Eric, Androulakis IoannisP 2007, 'Bioinformatics analysis of the early inflammatory response in a rat thermal injurymodel', BMC Bioinformaticshttp://www.biomedcentral.com/1471-2105/8/10. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Among them are inadequate dietary intake, malabsorption, increased protein losses, hypermetabolism, insulin resistance, gastrointestinal bleeding, ascites, inflammation/infection, and hyponatremia.
Chantal Bémeur, Paul Desjardins, Roger F. Butterworth 2010, 'Role of Nutrition in the Management of Hepatic Encephalopathy in End-Stage Liver Failure',Journal of Nutrition and Metabolismhttp://dx.doi.org/10.1155/2010/489823. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)