Airway hyperreactivity in the sensitized animals was inhibited by pre-treatment with dexamethasone.
Christopher Skappak, Ramses Ilarraza, Ying-Qi Wu, Matthew G Drake, Darryl J Adamko 2017, 'Virus-induced asthma attack: The importance of allergic inflammation in response toviral antigen in an animal model of asthma.', PLoS ONEhttp://europepmc.org/articles/PMC5524340?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, airway hyperreactivity and lung sections were examined.
Huihui You, Rui Li, Chenxi Wei, Shaohui Chen, Lin Mao, Zhenye Zhang, Xu Yang 2016, 'Thymic Stromal Lymphopoietin Neutralization Inhibits the Immune Adjuvant Effect ofDi-(2-Ethylhexyl) Phthalate in Balb/c Mouse Asthma Model', PLOS ONE10.1371/journal.pone.0159479. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the side effects such as bronchial hyperreactivity may be intolerable.
Yi Ji, Siyuan Chen, Qi Wang, Bo Xiang, Zhicheng Xu, Lin Zhong, Kaiying Yang, GuoyanLu, Liqin Qiu 2018, 'Intolerable side effects during propranolol therapy for infantile hemangioma: frequency,risk factors and management', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-22787-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Additionally, assessments of airway hyperreactivity were evaluated through direct pulmonary function measurements.
Jorge L Medina, Jacqueline J Coalson, Edward G Brooks, Claude Jourdan Le Saux, VickiT Winter, Adriana Chaparro, Molly F R Principe, Laura Solis, T R Kannan, Joel B Baseman,Peter H Dube 2014, 'Mycoplasma pneumoniae CARDS toxin exacerbates ovalbumin-induced asthma-like inflammationin BALB/c mice.', PLoS ONEhttp://europepmc.org/articles/PMC4109942?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ozone exposure causes airway hyperreactivity and increases hospitalizations resulting from pulmonarycomplications.
Kirsten C Verhein, Francesco G Salituro, Mark W Ledeboer, Allison D Fryer, David BJacoby 2013, 'Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airwayhyperreactivity in guinea pigs.', PLoS ONEhttp://europepmc.org/articles/PMC3776780?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In females, estrogen interferes with inflammatory signaling pathways that may modulate airway hyperreactivity.
Ya-Chen Huang, Ya-Chen Huang, Zung Fan Yuan, Zung Fan Yuan, Chang-Huan Yang, Yan-JhihShen, Jyun-Yi Lin, Jyun-Yi Lin, Ching Jung Lai, Ching Jung Lai 2018, 'Estrogen Modulates the Sensitivity of Lung Vagal C Fibers in Female Rats Exposed toIntermittent Hypoxia', Frontiers in Physiologyhttps://www.frontiersin.org/article/10.3389/fphys.2018.00847/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The most pronounced bronchial obstruction and bronchial hyperreactivity were observed in patients with respiratory alkalosis.
Zh.D. Semydotska, I.A. Cherniacova, G.V. Eremenko 2015, 'RENAL RISCS IN DETERMINATION OF BRONCHIAL ASTHMA PHENOTYPES', Український Журнал Нефрології та Діалізуhttps://ukrjnd.com.ua/index.php/journal/article/view/160. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Airway hyperreactivity to aerosolized methacholine was determined.
Chia-Hsiu Hsu, Hai-Lun Sun, Ji-Nan Sheu, Min-Sho Ku, Chun-Ming Hu, You Chan, Ko-HuangLue 2008, 'Effects of the Immunomodulatory Agent Cordyceps militaris on Airway Inflammation ina Mouse Asthma Model', Pediatrics and Neonatologyhttp://www.sciencedirect.com/science/article/pii/S1875957209600048. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Bronchial hyperreactivity was measured using barometric plethysmography.
Portet Karine, Bichon Florence, Michel Alain, Roumestan Caroline, Detoc Maëlle, HenriquetCorinne, Jaffuel Dany, Mathieu Marc 2007, 'Anti-inflammatory properties of desipramine and fluoxetine', Respiratory Researchhttp://respiratory-research.com/content/8/1/35. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)