释义 |
idiotype in British English (ˈɪdɪəʊˌtaɪp) nounthe unique part of an antibody Examples of 'idiotype' in a sentenceidiotype Anti-idiotype antibodies have potential therapeutic applications in many fields, including autoimmune diseases.Immunization induces an anti-idiotype antibody response that maintains dormancy.We have previously reported on idiotype/anti-idiotype-receptor transactions in clinical human schistosomiasis.The anti-idiotype antibodies are the peerless therapeutic candidate as they mimic the antigenic structure and potentiate antibody and cell-mediated immunity.Protection can be achieved via the transfer of monoclonal antibodies recognizing the epitope or by immunization with anti-idiotype monoclonal antibodies.Even in the absence of foreign antigen, these anti-idiotype antibodies have the potential to provide long-lasting immunity.Selective antigen-mimicking anti-idiotype antibody facilitates the assessment of therapeutic antibody in the detection, quantitation and characterization of antibody immune responses.In contrast to the rapid induction anti-idiotype response, detection of ganglioside-specific antibodies in responsive animals may require repeated boosting. |