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单词 immunotoxin
释义

immunotoxin in British English

(ˌɪmjʊnəʊˈtɒksɪn)
noun
a toxin with immunosuppressive effects

immunotoxin in American English

(ˌimjənouˈtɑksɪn, iˌmjuː-)
noun
Immunology
a monoclonal antibody linked to a toxin with the intention of destroying a specific target cell while leaving adjacent cells intact
Word origin
[immuno- + toxin]immuno- is a combining form representing immune or immunity in compound words. Other words that use the affix immuno- include: immunodiffusion, immunogenetics, immunoglobulin, immunology, immunotherapy

Examples of 'immunotoxin' in a sentence
immunotoxin

Immunofluorescence revealed that the immunotoxin localized to endoplasmic reticulum 24 h later.
Minghua Lv, Feng Qiu, Tingting Li, Yuanjie Sun, Chunmei Zhang, Ping Zhu, Xiaokun Qi,Jun Wan, Kun Yang, Kui Zhang 2015, 'Construction, Expression, and Characterization of a Recombinant Immunotoxin TargetingEpCAM', Mediators of Inflammationhttp://dx.doi.org/10.1155/2015/460264. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Intravitreal injection of this immunotoxin results in targeted destruction of melanopsin cells.
Didem Göz, Keith Studholme, Douglas A Lappi, Mark D Rollag, Ignacio Provencio, LawrenceP Morin 2008, 'Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugatealters the effects of light on mouse circadian rhythms.', PLoS ONEhttp://europepmc.org/articles/PMC2519834?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The resulting immunotoxin did not exhibit hemolytic activity except under reducing conditions.
ANA D AVILA, CARLOS F CALDERÓN, RITA M PEREZ, CARMEN PONS, CELIA M PEREDA, ANA R ORTIZ 2007, 'Construction of an immunotoxin by linking a monoclonal antibody against the humanepidermal growth factor receptor and a hemolytic toxin', Biological Researchhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200008. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
To conclude, our study provides a promising therapeutic approach for immunotoxin-based esophageal cancer treatment.
Yun Yang, Ziyin Tian, Yanke Ding, Xiaojing Li, Ziheng Zhang, Liu Yang, Fangyu Zhao,Feng Ren, Rui Guo 2018, 'EGFR-Targeted Immunotoxin Exerts Antitumor Effects on Esophageal Cancers by IncreasingROS Accumulation and Inducing Apoptosis via Inhibition of the Nrf2-Keap1 Pathway',Journal of Immunology Researchhttp://dx.doi.org/10.1155/2018/1090287. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Synergy was most evident when cells exhibited resistance to the immunotoxin alone.
Abid R. Mattoo, Ira Pastan, David FitzGerald 2013, 'Combination Treatments with the PKC Inhibitor, Enzastaurin, Enhance the Cytotoxicityof the Anti-Mesothelin Immunotoxin, SS1P', PLoS ONE10.1371/journal.pone.0075576. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
To test this idea, we developed a specific immunotoxin consisting of an anti-melanopsin antibodyconjugated to the ribosome-inactivating protein, saporin.
Didem Göz, Keith Studholme, Douglas A. Lappi, Mark D. Rollag, Ignacio Provencio, LawrenceP. Morin 2008, 'Targeted Destruction of Photosensitive Retinal Ganglion Cells with a Saporin ConjugateAlters the Effects of Light on Mouse Circadian Rhythms', PLoS ONE10.1371/journal.pone.0003153. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A drastic growth inhibition (>80–90%) of the cell colonies was reached after 3 days of immunotoxin treatment.
Vanina Torres Demichelis, Aldo A. Vilcaes, Ramiro Iglesias-Bartolomé, Fernando M.Ruggiero, Jose L. Daniotti 2013, 'Targeted Delivery of Immunotoxin by Antibody to Ganglioside GD3: A Novel Drug DeliveryRoute for Tumor Cells', PLoS ONE10.1371/journal.pone.0055304. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The immunotoxin concept uses bacterial or plant toxins, coupled to antibodies or natural ligands targeting cancer cells.
Nina Berges, Grit Hehmann-Titt, Dmitrij Hristodorov, Georg Melmer, Theo Thepen, StefanBarth 2014, 'Human Cytolytic Fusion Proteins: Modified Versions of Human Granzyme B and AngiogeninHave the Potential to Replace Bacterial Toxins in Targeted Therapies against CD64+Diseases', Antibodieshttp://www.mdpi.com/2073-4468/3/1/92. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
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更新时间：2024/12/22 15:27:13