a white crystalline compound, C7H10N2OS, that interferes with the synthesis of thyroid hormone by the thyroid gland: used in the treatment of hyperthyroidism
Word origin
[propyl + thiouracil]
Examples of 'propylthiouracil' in a sentence
propylthiouracil
The patient was treated with propylthiouracil and propranolol, but hyperthyroidism was not well controlled.
Won Kyoung Cho, Moon-Bae Ahn, Woori Jang, Hyojin Chae, Myungshin Kim, Byung-Kyu Suh 2018, 'Nonautoimmune congenital hyperthyroidism due to p.Asp633Glu mutation in the gene',Annals of Pediatric Endocrinology & Metabolismhttp://e-apem.org/upload/pdf/apem-2018-23-4-235.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient was diagnosed with propylthiouracil related agranulocytosis, diffuse toxic goiter, and thyro-gastric syndrome.
Anna Candoni 2017, 'Graves' disease thyrotoxicosis and propylthiouracil related agranulocytosis successfullytreated with therapeutic plasma exchange and g-csf followed by total thyroidectomy.',Mediterranean Journal of Hematology and Infectious Diseaseshttp://www.mjhid.org/index.php/mjhid/article/view/3065. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient progressed to thyroid storm, treated with propylthiouracil, potassium iodine, hydrocortisone, and cholestyramine.
Peter V. Bui, Sonia N. Zaveri, J. Rush Pierce Jr. 2016, 'Sanguineous Pericardial Effusion and Cardiac Tamponade in the Setting of Graves' Disease:Report of a Case and Review of Previously Reported Cases', Case Reports in Medicinehttp://dx.doi.org/10.1155/2016/9653412. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Neither species increased the propylthiouracil-induced decrease in serum levels of thyroid hormones.
Dianna Liu, Feng Chen, Xue Yu, Linlin Xiu, Haiyan Liu, Shaohong Chen, Jie Gao, ChenZhang, Na Li, Cheng He, Gansheng Zhong 2019, 'Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effectsin a Rat Goiter Model?', Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2019/5645620. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The procedure was employed for propylthiouracil determination in medications.
Rodolfo de Melo Magalhães Santana, Mauro Korn, Josué Carinhanha Caldas Santos 2013, 'Influência de processos antagônicos no desenvolvimento de sistema de análises em fluxopara a determinação espectrofotométrica de propiltiouracil em medicamentos Influenceof antagonic processes on the development of flow analysis system for spectrophotometricdetermination of propylthiouracil in medications', Química Novahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100017. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We observed that methimazole, thiouracil, methylthiouracil, propylthiouracil, ambazone, and thioacetazoneinhibited mushroom tyrosinase.
Joonhyeok Choi, Jun-Goo Jee 2015, 'Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/16/12/26114. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient responded to potassium repletion and was treated with propylthiouracil and propranolol.
Tina K. Thethi, Rosemarie Parks, Bonnie Katalenich, Pankdeep Chhabra, Julie McCaw,Stephanie Syu, Tuyen Nguyen, Joshua Larrazolo, Kartik Munshi, Jay Waddadar, PrathimaNagireddy 2014, 'Case of Thyrotoxic Periodic Paralysis in a Caucasian Male and Review of Literature',Case Reports in Medicinehttp://dx.doi.org/10.1155/2014/314262. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
She was treated with propylthiouracil with gradual recovery.
Ashok Krishna Bhuyan, Dipti Sarma, Uma Kaimal Saikia, Bipul Kumar Choudhury 2014, 'Grave's Disease with Severe Hepatic Dysfunction: A Diagnostic and Therapeutic Challenge',Case Reports in Medicinehttp://dx.doi.org/10.1155/2014/790458. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Exposure to propylthiouracil in early pregnancy may be associated with an increased risk of birth defects.
Alexander A. Leung, Jennifer Yamamoto, Paola Luca, Paul Beaudry, Julie McKeen 2015, 'Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in EarlyPregnancy', Case Reports in Endocrinologyhttp://dx.doi.org/10.1155/2015/789762. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)