This compound was also found to be proteolytically much more stable than its linear counterpart.
Jiajia Liu, Yajun Huang, Weiping Zheng 2016, 'A Selective Cyclic Peptidic Human SIRT5 Inhibitor', Moleculeshttp://www.mdpi.com/1420-3049/21/9/1217. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hence, proteolytically stable peptidomimetics were designed to overcome these drawbacks.
Athina Andrea, Natalia Molchanova, Håvard Jenssen 2018, 'Antibiofilm Peptides and Peptidomimetics with Focus on Surface Immobilization', Biomoleculeshttp://www.mdpi.com/2218-273X/8/2/27. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Several proteolytically generated endogenous molecules have been identified which exhibit angioinhibition and/or antitumor activities.
Chandra Shekhar Boosani, Yakkanti A. Sudhakar 2011, 'Proteolytically Derived Endogenous Angioinhibitors Originating from the ExtracellularMatrix', Pharmaceuticalshttp://www.mdpi.com/1424-8247/4/12/1551/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Forced expression of wild type or proteolytically inactive caspases in cultured cardiomyocytes induced expression of genes promoting cell division.
Maria Cardona, Juan Antonio López, Anna Serafín, Anthony Rongvaux, Javier Inserte,David García-Dorado, Richard Flavell, Marta Llovera, Xavier Cañas, Jesús Vázquez,Daniel Sanchis 2015, 'Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing MouseHeart.', PLoS ONEhttp://europepmc.org/articles/PMC4487935?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Aggregation forms proteolytically stable core polymers restricted to the repeat domain, and this binding interaction has prion-like properties.
Robert Y. K. Lai, Charles R. Harrington, Claude M. Wischik 2016, 'Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease',Biomoleculeshttp://www.mdpi.com/2218-273X/6/2/19. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These results provide valuable information for the application of fluorinated amino acids in the design of proteolytically stable peptide-based pharmaceuticals.
Susanne Huhmann, Anne-Katrin Stegemann, Kristin Folmert, Damian Klemczak, Johann Moschner,Michelle Kube, Beate Koksch 2017, 'Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on proteasedigestion', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.13.279. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Addition of yeast extract or proteolytically degraded whey proteins did not improve the recombinant protein yield.
Neubauer Peter, Vasala Antti, Viitanen Mikko I, Alatossava Tapani 2003, 'Cheese whey-induced high-cell-density production of recombinant proteins in Escherichiacoli', Microbial Cell Factorieshttp://www.microbialcellfactories.com/content/2/1/2. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The presence and distribution of these presumably proteolytically inactive p20-containing enzymes has until now escaped attention.
Marina Klemenčič, Marina Klemenčič, Johannes Asplund-Samuelsson, Marko Dolinar, ChristianeFunk 2019, 'Phylogenetic Distribution and Diversity of Bacterial Pseudo-Orthocaspases UnderlineTheir Putative Role in Photosynthesis', Frontiers in Plant Sciencehttps://www.frontiersin.org/article/10.3389/fpls.2019.00293/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)