an isomer of indigotin which may be naturally extracted from the Indigo plant of China, and effective in the treatment of leukaemia
Examples of 'indirubin' in a sentence
indirubin
The plant extract indirubin and its chemical derivatives represent new and promising antitumor strategies.
Marwa Y. Soltan, Uly Sumarni, Chalid Assaf, Peter Langer, Ulrich Reidel, Jürgen Eberle 2019, 'Key Role of Reactive Oxygen Species (ROS) in Indirubin Derivative-Induced Cell Deathin Cutaneous T-Cell Lymphoma Cells', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/20/5/1158. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This pathway can be efficiently activated by an indirubin derivative.
Marwa Y. Soltan, Uly Sumarni, Chalid Assaf, Peter Langer, Ulrich Reidel, Jürgen Eberle 2019, 'Key Role of Reactive Oxygen Species (ROS) in Indirubin Derivative-Induced Cell Deathin Cutaneous T-Cell Lymphoma Cells', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/20/5/1158. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the poor water solubility of indirubin has limited its application.
Chen ZQ, Liu Y, Zhao JH, Wang L, Feng NP 2012, 'Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatableself-microemulsifying drug delivery system', International Journal of Nanomedicinehttp://www.dovepress.com/improved-oral-bioavailability-of-poorly-water-soluble-indirubin-by-a-s-a9334. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Various parts of the tree have been reported to contain oils, keto steroids, glycosides, couroupitine, indirubin, isatin, and phenolic substances.
Preetha Devaraj, Prachi Kumari, Chirom Aarti, Arun Renganathan 2013, 'Synthesis and Characterization of Silver Nanoparticles Using Cannonball Leaves andTheir Cytotoxic Activity against MCF-7 Cell Line', Journal of Nanotechnologyhttp://dx.doi.org/10.1155/2013/598328. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This results in the production of indigo and indirubin, which combine to give a purple appearance.
Teshome Gebrmichael , Fikirte Feleke, Waseem Ahmed, Madhulika Urella, Samson Teka 2017, 'Purple Urine Bag Syndrome: An Educational Case of a Colorful Condition in the ChronicallyCatheterized', Marshall Journal of Medicinehttps://mds.marshall.edu/cgi/viewcontent.cgi?article=1087&context=mjm. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)