an acid sulfite containing the monovalent negative radical HSO3
bisulfite in American English
(baiˈsʌlfait)
noun
Chemistry
a salt of sulfurous acid, containing the HSO3−group; an acid sulfite; a hydrogen sulfite, as sodium bisulfite, NaHSO3
Also: bisulphite
Word origin
[1885–90; bi-1 + sulfite]This word is first recorded in the period 1885–90. Other words that entered Englishat around the same time include: booster, classified, lineup, reactor, scrumbi- is a combining form meaning “twice,” “two,” used in the formation of compound words.Other words that use the affix bi- include: biceps, bilateral, bisect, bivalent, bivalve
Examples of 'bisulfite' in a sentence
bisulfite
Array based analyses identified 5 loci for further confirmation with bisulfite pyrosequencing.
Carmen J. Marsit, E. Andres Houseman, Brock C. Christensen, Luc Gagne, Margaret R.Wrensch, Heather H. Nelson, Joseph Wiemels, Shichun Zheng, John K. Wiencke, AngelineS. Andrew, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey 2010, 'Identification of Methylated Genes Associated with Aggressive Bladder Cancer', PLoS ONE10.1371/journal.pone.0012334. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We validated the results by individual traditional bisulfite sequencing for selected genomic regions.
Huy Q Dinh, Manu Dubin, Fritz J Sedlazeck, Nicole Lettner, Ortrun Mittelsten Scheid,Arndt von Haeseler 2012, 'Advanced methylome analysis after bisulfite deep sequencing: an example in Arabidopsis.',PLoS ONEhttp://europepmc.org/articles/PMC3401099?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Methylation-specific primers differentially amplified bisulfite-treated samples as would be expected under standard laboratory conditions.
Anna-Sophia Boguraev, Holly C. Christensen, Ashley R. Bonneau, John A. Pezza, NicoleM. Nichols, Antonio J. Giraldez, Michelle M. Gray, Brandon M. Wagner, Jordan T. Aken,Kevin D. Foley, D. Scott Copeland, Sebastian Kraves, Ezequiel Alvarez Saavedra 2017, 'Successful amplification of DNA aboard the International Space Station', npj Microgravityhttp://link.springer.com/article/10.1038/s41526-017-0033-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Methylation status of α-internexin was evaluated by bisulfite genomic sequencing.
Yuhong Wang, Yuanjia Chen, Xiaoxing Li, Wanming Hu, Yu Zhang, Luohai Chen, Minhu Chen,Jie Chen 2018, 'Loss of expression and prognosis value of alpha-internexin in gastroenteropancreaticneuroendocrine neoplasm', BMC Cancerhttp://link.springer.com/article/10.1186/s12885-018-4449-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, these minor apparent changes could not be independently confirmed by bisulfite sequencing-based approaches.
Christoph Lahtz, Sang-In Kim, Steven E Bates, Arthur X Li, Xiwei Wu, Gerd P Pfeifer 2013, 'UVB irradiation does not directly induce detectable changes of DNA methylation inhuman keratinocytes [v1; ref status: indexed, http://f1000r.es/np]', F1000Researchhttp://f1000research.com/articles/2-45/v1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We evaluated the performance of our approach and compared it to other bisulfite aligners.
Pellegrini Matteo, Cokus Shawn J, Chen Pao-Yang 2010, 'BS Seeker: precise mapping for bisulfite sequencing', BMC Bioinformaticshttp://www.biomedcentral.com/1471-2105/11/203. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This was followed by bisulfite deep sequencing.
Cheng Y, Pan Y, Pan Y, Wang O 2019, 'MNX1-AS1 is a functional oncogene that induces EMT and activates the AKT/mTOR pathwayand MNX1 in breast cancer', Cancer Management and Researchhttps://www.dovepress.com/mnx1-as1-is-a-functional-oncogene-that-induces-emt-and-activates-the-a-peer-reviewed-article-CMAR. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Aligning bisulfite short reads to a reference genome has been a challenging task.
Hong Tran, Jacob Porter, Ming-an Sun, Hehuang Xie, Liqing Zhang 2014, 'Objective and Comprehensive Evaluation of Bisulfite Short Read Mapping Tools', Advances in Bioinformaticshttp://dx.doi.org/10.1155/2014/472045. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, libraries constructed with methylated adapters prior to solution hybridization also enable targeted bisulfite sequencing.
Kenneth Day, Jun Song, Devin Absher 2014, 'Targeted sequencing of large genomic regions with CATCH-Seq.', PLoS ONEhttp://europepmc.org/articles/PMC4214737?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)